SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3etc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 GLU A 398
HIS A 432
ASP A 385
 None
 0.88A 1i9gA-3etcA:
undetectable		 1i9gA-3etcA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 5 GLU A 466
ARG A 450
ASP A 435
THR A 355
 NO3  A1001 (-4.4A)
None
None
None
 1.27A 1k4tA-3etcA:
undetectable		 1k4tA-3etcA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_D_MTXD354_1
(PTERIDINE REDUCTASE
1)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 PRO A 227
LEU A 262
TYR A 263
LEU A  93
PRO A 117
 None
 1.24A 1p33D-3etcA:
3.8		 1p33D-3etcA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 5 GLU A 466
ARG A 450
ASP A 435
THR A 355
 NO3  A1001 (-4.4A)
None
None
None
 1.36A 1rr8C-3etcA:
undetectable		 1rr8C-3etcA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 5 GLU A 466
ARG A 450
ASP A 435
THR A 355
 NO3  A1001 (-4.4A)
None
None
None
 1.30A 1rrjA-3etcA:
undetectable		 1rrjA-3etcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 5 TYR A 277
PHE A 280
ILE A 303
TYR A 247
 EPE  A 996 (-3.5A)
None
None
EPE  A 996 (-4.4A)
 1.42A 1vaoA-3etcA:
3.6		 1vaoA-3etcA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 5 TYR A 277
PHE A 280
ILE A 303
TYR A 247
 EPE  A 996 (-3.5A)
None
None
EPE  A 996 (-4.4A)
 1.42A 1vaoB-3etcA:
3.6		 1vaoB-3etcA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 9 PHE A  24
THR A 376
VAL A 409
GLY A 410
ILE A 231
 None
None
GOL  A1002 (-3.6A)
None
None
 1.19A 2a1oB-3etcA:
undetectable		 2a1oB-3etcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 ILE A 494
LEU A 514
VAL A 518
GLU A 468
LEU A 471
 None
 1.04A 2bxfA-3etcA:
undetectable		 2bxfA-3etcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 ILE A 494
LEU A 514
VAL A 518
GLU A 468
LEU A 471
 None
 1.04A 2bxfB-3etcA:
undetectable		 2bxfB-3etcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 CYH A 257
HIS A 230
VAL A 274
LEU A 206
TYR A 226
 None
None
EPE  A 996 (-3.8A)
None
None
 1.25A 2prgB-3etcA:
undetectable		 2prgB-3etcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 11 HIS A 109
ALA A  77
GLY A  86
ILE A  85
VAL A 140
 None
 1.08A 2uxpB-3etcA:
undetectable		 2uxpB-3etcA:
17.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 8 GLY A 327
GLY A 351
GLN A 352
THR A 353
 1PE  A 994 (-3.6A)
1PE  A 994 (-4.4A)
None
GOL  A1005 ( 2.7A)
 0.57A 2wd9B-3etcA:
49.6		 2wd9B-3etcA:
37.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 PHE A 101
HIS A 230
LEU A  69
LEU A 206
TYR A 226
 None
 1.40A 3adsA-3etcA:
undetectable		 3adsA-3etcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 ILE A 303
ALA A 326
ALA A 323
ALA A 250
VAL A 249
 None
1PE  A 994 ( 3.7A)
None
None
EPE  A 996 (-3.6A)
 1.05A 3jb3A-3etcA:
undetectable		 3jb3A-3etcA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 11 ILE A 494
ALA A 470
GLU A 468
VAL A 462
GLY A 463
 None
 0.91A 3kw4A-3etcA:
undetectable		 3kw4A-3etcA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 7 LEU A  69
GLY A 107
ALA A  76
PHE A  80
 None
 0.81A 3tehB-3etcA:
undetectable		 3tehB-3etcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 PHE A 280
LEU A 346
VAL A 325
VAL A 334
PHE A 297
 None
 1.30A 3u9fB-3etcA:
undetectable
3u9fC-3etcA:
undetectable		 3u9fB-3etcA:
17.38
3u9fC-3etcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 PHE A 280
LEU A 346
VAL A 325
VAL A 334
PHE A 297
 None
 1.32A 3u9fH-3etcA:
undetectable
3u9fI-3etcA:
undetectable		 3u9fH-3etcA:
17.38
3u9fI-3etcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 8 TYR A 263
HIS A 109
TYR A 208
LEU A  93
 None
None
GOL  A1005 ( 4.2A)
None
 1.26A 3uzzB-3etcA:
undetectable		 3uzzB-3etcA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 CYH A 205
VAL A  39
PHE A  32
LEU A   5
PHE A   8
 None
 1.45A 4iaqA-3etcA:
undetectable		 4iaqA-3etcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 8 TYR A 431
THR A 425
THR A 353
VAL A 220
 None
None
GOL  A1005 ( 2.7A)
None
 1.01A 4l4aA-3etcA:
undetectable		 4l4aA-3etcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 CYH A 257
HIS A 230
VAL A 274
LEU A 206
TYR A 226
 None
None
EPE  A 996 (-3.8A)
None
None
 1.25A 4o8fB-3etcA:
undetectable		 4o8fB-3etcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 6 GLU A  15
PHE A  14
PHE A  20
TYR A  17
 None
 1.47A 4uciA-3etcA:
undetectable		 4uciA-3etcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 7 GLU A  15
PHE A  14
PHE A  20
TYR A  17
 None
 1.48A 4uciB-3etcA:
undetectable		 4uciB-3etcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 GLU A 398
HIS A 432
ASP A 385
 None
 0.76A 5c0oG-3etcA:
3.9		 5c0oG-3etcA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 LEU A   4
PHE A  32
ILE A 267
 None
 0.72A 5dzk1-3etcA:
undetectable
5dzkF-3etcA:
undetectable
5dzkM-3etcA:
undetectable		 5dzk1-3etcA:
7.14
5dzkF-3etcA:
18.32
5dzkM-3etcA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 8 GLU A 328
PHE A 350
GLY A 349
THR A 433
 None
1PE  A 994 ( 4.2A)
None
None
 0.86A 5flcB-3etcA:
undetectable		 5flcB-3etcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 8 GLU A 328
PHE A 350
GLY A 349
THR A 433
 None
1PE  A 994 ( 4.2A)
None
None
 0.87A 5flcF-3etcA:
undetectable		 5flcF-3etcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 LEU A 163
ILE A 127
VAL A 147
THR A 119
ALA A 134
 None
 1.15A 6djzA-3etcA:
undetectable		 6djzA-3etcA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 LEU A 228
ILE A  26
THR A 355
ILE A 267
ILE A 231
 None
GOL  A1002 (-4.2A)
None
None
None
 0.97A 6emuA-3etcA:
undetectable		 6emuA-3etcA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 LEU A 228
ILE A  26
THR A 355
ILE A 267
ILE A 231
 None
GOL  A1002 (-4.2A)
None
None
None
 0.99A 6emuB-3etcA:
2.1		 6emuB-3etcA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 LEU A 228
ILE A  26
THR A 355
ILE A 267
ILE A 231
 None
GOL  A1002 (-4.2A)
None
None
None
 0.98A 6emuC-3etcA:
undetectable		 6emuC-3etcA:
17.53