SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eu8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		4 / 8 GLY A 118
PHE A 119
LEU A 120
ARG A 112
 EDO  A 452 ( 4.0A)
None
None
EDO  A 474 (-3.8A)
 0.74A 1d0vA-3eu8A:
undetectable		 1d0vA-3eu8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		5 / 12 GLY A 441
SER A 236
MET A 433
LEU A 289
LEU A 204
 None
 1.36A 1fm6D-3eu8A:
undetectable		 1fm6D-3eu8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_1
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		4 / 4 THR A 360
GLN A 283
GLU A 225
ASP A 152
 None
None
EDO  A  21 (-2.8A)
None
 1.45A 1nw3A-3eu8A:
undetectable		 1nw3A-3eu8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		4 / 5 PRO A  76
ARG A  68
ARG A 407
ASP A  72
 EDO  A 454 (-4.1A)
EDO  A 472 (-2.8A)
EDO  A 454 (-3.2A)
None
 1.33A 2rhmD-3eu8A:
undetectable		 2rhmD-3eu8A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		4 / 8 GLY A 240
ILE A 228
VAL A 220
SER A 236
 None
 0.79A 2yoeB-3eu8A:
undetectable
2yoeC-3eu8A:
2.0		 2yoeB-3eu8A:
19.95
2yoeC-3eu8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		5 / 12 PHE A 158
GLU A 155
ALA A 336
PHE A 280
TYR A 284
 None
 1.31A 3apwB-3eu8A:
undetectable		 3apwB-3eu8A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		5 / 12 ALA A 234
GLY A 240
LEU A 232
TYR A 230
LEU A 227
 None
 1.31A 3bxoA-3eu8A:
undetectable		 3bxoA-3eu8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		3 / 3 GLU A 177
SER A 105
VAL A 104
 EDO  A 458 ( 4.1A)
None
None
 0.69A 3eeoA-3eu8A:
undetectable		 3eeoA-3eu8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		4 / 7 LEU A  96
ARG A 106
SER A 434
GLY A 173
 None
EDO  A 458 ( 3.9A)
None
None
 1.06A 3hcrB-3eu8A:
undetectable		 3hcrB-3eu8A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		4 / 8 LEU A 289
PHE A 447
TYR A 302
TYR A 223
 None
 1.27A 3po7A-3eu8A:
undetectable		 3po7A-3eu8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		4 / 4 PHE A 280
TYR A 271
ILE A 366
LEU A 363
 None
 1.39A 3sudA-3eu8A:
undetectable		 3sudA-3eu8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		4 / 5 PHE A 280
TYR A 271
ILE A 366
LEU A 363
 None
 1.31A 3sueC-3eu8A:
undetectable		 3sueC-3eu8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		5 / 12 LEU A 159
ILE A 411
GLY A  91
ILE A  95
ALA A  65
 None
None
EDO  A 474 (-3.3A)
None
EDO  A 474 (-3.6A)
 1.37A 3uj7A-3eu8A:
undetectable		 3uj7A-3eu8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		5 / 12 GLY A  89
GLY A 162
ILE A 116
ALA A  65
PHE A 158
 None
None
EDO  A 474 (-4.9A)
EDO  A 474 (-3.6A)
None
 1.11A 4kicA-3eu8A:
undetectable		 4kicA-3eu8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		5 / 12 GLY A  89
GLY A 162
ILE A 116
ALA A  65
PHE A 158
 None
None
EDO  A 474 (-4.9A)
EDO  A 474 (-3.6A)
None
 1.09A 4kicB-3eu8A:
undetectable		 4kicB-3eu8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		6 / 12 ALA A  65
LEU A  64
ILE A  95
ILE A 184
LEU A 163
GLY A  89
 EDO  A 474 (-3.6A)
None
None
None
None
None
 1.40A 4r3aB-3eu8A:
undetectable		 4r3aB-3eu8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		3 / 3 ARG A 125
LYS A 186
GLU A 190
 None
 0.74A 5d0yA-3eu8A:
undetectable		 5d0yA-3eu8A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		5 / 9 ALA A 165
LEU A 287
GLY A 288
LEU A 428
LEU A  96
 None
 1.00A 5dqfA-3eu8A:
undetectable		 5dqfA-3eu8A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		5 / 9 GLN A 161
PHE A 158
GLY A  86
SER A  88
ILE A 411
 None
None
None
EDO  A 474 (-4.0A)
None
 1.35A 5entC-3eu8A:
undetectable		 5entC-3eu8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		4 / 7 PHE A 447
ALA A 251
GLY A 222
TYR A 271
 None
 0.89A 5uxdA-3eu8A:
undetectable		 5uxdA-3eu8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3eu8 PUTATIVE
GLUCOAMYLASE
(Bacteroides
fragilis) 		5 / 9 ILE A 411
PHE A 158
SER A  85
SER A  88
GLY A  89
 None
None
None
EDO  A 474 (-4.0A)
None
 1.38A 6awpA-3eu8A:
undetectable		 6awpA-3eu8A:
20.14