SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3euh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
(Escherichia
coli) 		5 / 12 MET A 178
LEU A 208
LEU A 207
GLY A 213
LEU A 215
 None
 1.22A 1g50B-3euhA:
undetectable		 1g50B-3euhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_B_PE2B2_1
(THYMIDINE KINASE)		 3euh MUKE
(Escherichia
coli) 		5 / 12 GLU C 218
MET C  57
GLN C  60
ARG C  76
GLU C  79
 None
 1.47A 1ki3B-3euhC:
0.0		 1ki3B-3euhC:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
(Escherichia
coli) 		5 / 12 HIS A 282
ILE A 201
ARG A 286
ALA A 288
GLU A 205
 None
 1.43A 1ki7B-3euhA:
undetectable		 1ki7B-3euhA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
(Escherichia
coli) 		3 / 3 ASP A 278
LYS A 283
ARG A 286
 None
 1.15A 1ra8A-3euhA:
undetectable		 1ra8A-3euhA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
(Escherichia
coli) 		5 / 10 ASP A 172
ILE A 171
ILE A 263
GLY A 267
ILE A 271
 None
 0.93A 1sh9B-3euhA:
undetectable		 1sh9B-3euhA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
MUKE
(Escherichia
coli) 		4 / 7 LEU A 315
LEU C  97
SER C  98
VAL A 305
 None
 0.78A 1tyrB-3euhA:
undetectable		 1tyrB-3euhA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
(Escherichia
coli) 		5 / 12 ALA A 139
ILE A 236
VAL A 164
ALA A 165
PHE A 168
 None
 0.73A 1uduB-3euhA:
undetectable		 1uduB-3euhA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 3euh MUKE
(Escherichia
coli) 		4 / 8 GLY C 217
GLU C 218
ALA C 219
ILE C 214
 None
 0.70A 2dtjA-3euhC:
undetectable
2dtjB-3euhC:
undetectable		 2dtjA-3euhC:
22.59
2dtjB-3euhC:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
(Escherichia
coli) 		5 / 12 MET A 178
LEU A 208
LEU A 207
GLY A 213
LEU A 215
 None
 1.22A 2j7xA-3euhA:
undetectable		 2j7xA-3euhA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
(Escherichia
coli) 		3 / 3 LEU A 123
MET A 127
MET A 178
 None
 0.89A 2vavF-3euhA:
undetectable		 2vavF-3euhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
MUKE
(Escherichia
coli) 		4 / 7 LEU A 315
LEU C  97
SER C  98
VAL A 305
 None
 0.75A 3d2tA-3euhA:
undetectable		 3d2tA-3euhA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
(Escherichia
coli) 		5 / 11 LEU A 129
VAL A 132
ILE A 263
LEU A 260
PHE A 168
 None
 1.12A 3fl9C-3euhA:
undetectable		 3fl9C-3euhA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
MUKE
(Escherichia
coli;
Escherichia
coli) 		4 / 8 ALA A 320
ILE C  92
ASN A 319
PRO C  86
 None
 1.01A 3fxrA-3euhA:
4.5		 3fxrA-3euhA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 3euh MUKE
(Escherichia
coli) 		4 / 5 LEU C 111
GLN C 127
LEU C 129
GLU C 128
 None
 1.14A 3h5gA-3euhC:
undetectable
3h5gB-3euhC:
undetectable		 3h5gA-3euhC:
8.19
3h5gB-3euhC:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3euh MUKE
(Escherichia
coli) 		4 / 6 LEU C  39
SER C  41
ARG C  43
LEU C  84
 None
 1.02A 3ravA-3euhC:
undetectable		 3ravA-3euhC:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RHG_A_BEZA369_0
(PUTATIVE
PHOPHOTRIESTERASE)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
MUKE
(Escherichia
coli;
Escherichia
coli) 		5 / 10 LEU C 113
PHE C 194
GLU C  79
ASP A 292
PHE A 297
 None
 1.43A 3rhgA-3euhC:
0.0		 3rhgA-3euhC:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3euh MUKE
(Escherichia
coli) 		4 / 5 ARG C  40
LEU C  84
VAL C  72
ASP C  36
 None
 1.17A 3ufnA-3euhC:
undetectable
3ufnB-3euhC:
undetectable		 3ufnA-3euhC:
18.47
3ufnB-3euhC:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
(Escherichia
coli) 		5 / 12 LEU A  86
LEU A  32
LEU A  29
ILE A 110
TYR A 114
 None
 1.14A 4a7aB-3euhA:
undetectable		 4a7aB-3euhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3euh MUKE
(Escherichia
coli) 		3 / 3 TYR C  70
PHE C  32
ARG C  40
 None
 1.08A 4g19D-3euhC:
undetectable		 4g19D-3euhC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
MUKE
(Escherichia
coli;
Escherichia
coli) 		3 / 3 ASP A 290
LYS A 283
LEU C 118
 None
 1.04A 4ptjA-3euhA:
undetectable		 4ptjA-3euhA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3euh MUKE
(Escherichia
coli) 		4 / 6 ARG C 211
ILE C 214
GLN C 210
ASP C 205
 None
 1.19A 4w5tA-3euhC:
undetectable		 4w5tA-3euhC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
(Escherichia
coli) 		3 / 3 ARG A 102
ASN A  39
ASP A 112
 None
 0.86A 5gwxA-3euhA:
undetectable		 5gwxA-3euhA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
(Escherichia
coli) 		6 / 11 ASP A 112
ILE A 115
ILE A 110
GLY A 107
THR A  37
LEU A  33
 None
 1.44A 5twjD-3euhA:
undetectable		 5twjD-3euhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3euh CHROMOSOME PARTITION
PROTEIN MUKF
(Escherichia
coli) 		3 / 3 ASP A  27
PHE A  56
ARG A  73
 None
 0.92A 5yw0A-3euhA:
undetectable		 5yw0A-3euhA:
21.76