SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3euo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 180
ALA A 182
LEU A 156
LEU A 235
THR A 118
None
1.12A 1qzfA-3euoA:
undetectable
1qzfA-3euoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 180
ALA A 182
LEU A 156
LEU A 235
THR A 118
None
1.12A 1qzfB-3euoA:
undetectable
1qzfB-3euoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 180
ALA A 182
LEU A 156
LEU A 235
THR A 118
None
1.12A 1qzfC-3euoA:
undetectable
1qzfC-3euoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 180
ALA A 182
LEU A 156
LEU A 235
THR A 118
None
1.12A 1qzfD-3euoA:
undetectable
1qzfD-3euoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 180
ALA A 182
LEU A 156
LEU A 235
THR A 118
None
1.12A 1qzfE-3euoA:
undetectable
1qzfE-3euoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 LEU A 183
THR A 121
LEU A 146
GLY A 127
MET A  87
None
1.38A 1v8bD-3euoA:
undetectable
1v8bD-3euoA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 ALA A 157
GLY A 377
GLY A 375
ILE A 150
LEU A 270
None
1.12A 1x1aA-3euoA:
undetectable
1x1aA-3euoA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 116
ALA A 182
LEU A 156
LEU A 235
THR A 118
None
1.15A 2oipC-3euoA:
undetectable
2oipC-3euoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 180
ALA A 182
LEU A 156
LEU A 235
THR A 118
None
1.17A 2oipC-3euoA:
undetectable
2oipC-3euoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 180
ALA A 182
LEU A 156
LEU A 385
THR A 118
None
1.19A 2oipC-3euoA:
undetectable
2oipC-3euoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
3 / 3 ARG A 350
GLU A 353
SER A 211
None
0.85A 2xctD-3euoA:
undetectable
2xctD-3euoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 10 VAL A 217
ILE A  14
LEU A 385
GLY A 371
ALA A 303
None
1.23A 2xf3A-3euoA:
undetectable
2xf3A-3euoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 10 LEU A  17
LEU A 385
LEU A 348
ARG A 352
ARG A 387
None
1.05A 2xn6A-3euoA:
undetectable
2xn6B-3euoA:
undetectable
2xn6A-3euoA:
21.52
2xn6B-3euoA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 9 LEU A 219
ILE A 178
SER A  13
LEU A  12
CYH A 166
None
1.12A 3ai9X-3euoA:
undetectable
3ai9X-3euoA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 116
ALA A 182
LEU A 156
LEU A 235
THR A 118
None
1.15A 3hj3C-3euoA:
undetectable
3hj3C-3euoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 180
ALA A 182
LEU A 156
LEU A 235
THR A 118
None
1.11A 3hj3C-3euoA:
undetectable
3hj3C-3euoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 180
ALA A 182
LEU A 156
LEU A 385
THR A 118
None
1.07A 3hj3C-3euoA:
undetectable
3hj3C-3euoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 380
VAL A 267
ALA A 271
SER A 274
LEU A 275
None
1.08A 3ln1C-3euoA:
undetectable
3ln1C-3euoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 HIS A 305
LEU A 250
ARG A 266
SER A 153
LEU A 270
None
1.22A 3okxA-3euoA:
undetectable
3okxA-3euoA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 GLY A  90
ALA A  94
ALA A 182
ALA A 342
SER A 340
None
0.95A 3sudA-3euoA:
undetectable
3sudA-3euoA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 GLY A  90
ALA A  94
GLN A  20
ILE A  63
VAL A 185
None
1.25A 4azwA-3euoA:
undetectable
4azwA-3euoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 MET A  45
VAL A  48
LEU A  49
VAL A 190
LEU A 194
None
1.03A 4o1zB-3euoA:
undetectable
4o1zB-3euoA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
6 / 12 VAL A 116
ALA A 182
LEU A 156
ILE A  14
LEU A 235
THR A 118
None
1.42A 4q0dA-3euoA:
undetectable
4q0dA-3euoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
6 / 12 VAL A 116
ALA A 182
LEU A 156
ILE A  14
LEU A 235
THR A 118
None
1.42A 4q0dB-3euoA:
undetectable
4q0dB-3euoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
6 / 12 VAL A 116
ALA A 182
LEU A 156
ILE A  14
LEU A 235
THR A 118
None
1.42A 4q0dE-3euoA:
undetectable
4q0dE-3euoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
4 / 7 ILE A 150
CYH A 120
GLY A 155
GLY A 154
None
0.79A 5a06A-3euoA:
undetectable
5a06A-3euoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
4 / 7 ILE A 150
CYH A 120
GLY A 155
GLY A 154
None
0.79A 5a06B-3euoA:
undetectable
5a06B-3euoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
4 / 7 ILE A 150
CYH A 120
GLY A 155
GLY A 154
None
0.78A 5a06C-3euoA:
undetectable
5a06C-3euoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
4 / 7 ILE A 150
CYH A 120
GLY A 155
GLY A 154
None
0.79A 5a06E-3euoA:
undetectable
5a06E-3euoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
4 / 7 ILE A 150
CYH A 120
GLY A 155
GLY A 154
None
0.78A 5a06F-3euoA:
undetectable
5a06F-3euoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
6 / 12 GLY A 375
ILE A 232
TYR A 233
GLY A  16
GLY A  18
HIS A 305
None
1.15A 5eqbA-3euoA:
undetectable
5eqbA-3euoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 GLY A 375
ILE A 232
TYR A 233
GLY A  18
HIS A 305
None
1.05A 5eslA-3euoA:
undetectable
5eslA-3euoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 VAL A 380
VAL A 267
ALA A 271
SER A 274
LEU A 275
None
1.15A 5ikrA-3euoA:
undetectable
5ikrA-3euoA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 LEU A 282
ALA A 303
SER A 329
THR A 278
ARG A 160
None
1.18A 5nd3B-3euoA:
undetectable
5nd3B-3euoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
4 / 7 VAL A 347
ILE A 334
SER A 339
THR A 343
None
0.95A 5vkqA-3euoA:
undetectable
5vkqD-3euoA:
undetectable
5vkqA-3euoA:
12.20
5vkqD-3euoA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
4 / 7 SER A 339
THR A 343
VAL A 347
ILE A 334
None
0.98A 5vkqA-3euoA:
undetectable
5vkqB-3euoA:
undetectable
5vkqA-3euoA:
12.20
5vkqB-3euoA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
4 / 8 SER A 339
THR A 343
VAL A 347
ILE A 334
None
0.94A 5vkqB-3euoA:
undetectable
5vkqC-3euoA:
undetectable
5vkqB-3euoA:
12.20
5vkqC-3euoA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
4 / 7 SER A 339
THR A 343
VAL A 347
ILE A 334
None
0.96A 5vkqC-3euoA:
undetectable
5vkqD-3euoA:
undetectable
5vkqC-3euoA:
12.20
5vkqD-3euoA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 GLY A 371
VAL A 267
LEU A 250
GLY A 307
ILE A 311
None
1.10A 5vooA-3euoA:
undetectable
5vooA-3euoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 GLY A 371
VAL A 267
LEU A 250
GLY A 307
ILE A 311
None
1.10A 5vooB-3euoA:
undetectable
5vooB-3euoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 GLY A 371
VAL A 267
LEU A 250
GLY A 307
ILE A 311
None
1.09A 5vooC-3euoA:
undetectable
5vooC-3euoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa)
5 / 12 LEU A  70
VAL A  71
SER A 192
PHE A 252
VAL A 185
None
1.44A 6a94A-3euoA:
undetectable
6a94A-3euoA:
21.25