SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3euw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 SER A  54
VAL A  52
PHE A  59
GLU A  57
 None
 1.13A 1dmiA-3euwA:
undetectable
1dmiB-3euwA:
undetectable		 1dmiA-3euwA:
20.77
1dmiB-3euwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A  18
ASN A  24
ILE A  67
ILE A  88
LEU A 288
 None
 1.26A 2bjfA-3euwA:
undetectable		 2bjfA-3euwA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 9 LEU A 248
GLU A 240
ILE A 141
GLY A 246
LEU A 147
 None
 1.16A 2qmmA-3euwA:
3.4		 2qmmA-3euwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A  18
ASN A  24
ILE A  67
ILE A  88
LEU A 288
 None
 1.13A 2rlcA-3euwA:
undetectable		 2rlcA-3euwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 6 ARG A 296
ASP A  65
ILE A  64
GLU A  28
 None
 1.32A 2ya7C-3euwA:
undetectable		 2ya7C-3euwA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A  59
GLU A  57
SER A  54
VAL A  52
 None
 1.07A 3dqtA-3euwA:
undetectable
3dqtB-3euwA:
undetectable		 3dqtA-3euwA:
19.40
3dqtB-3euwA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 166
GLY A 167
ALA A 315
ILE A 162
PRO A  95
 None
 1.07A 3jayA-3euwA:
undetectable		 3jayA-3euwA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLY A 111
ILE A  96
CYH A  92
PHE A 291
 None
 1.00A 3ko0B-3euwA:
undetectable
3ko0J-3euwA:
undetectable		 3ko0B-3euwA:
11.92
3ko0J-3euwA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLY A 111
ILE A  96
CYH A  92
PHE A 291
 None
 0.95A 3ko0K-3euwA:
undetectable
3ko0S-3euwA:
undetectable		 3ko0K-3euwA:
11.92
3ko0S-3euwA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 SER A  54
VAL A  52
PHE A  59
GLU A  57
 None
 1.05A 3n5tA-3euwA:
undetectable
3n5tB-3euwA:
undetectable		 3n5tA-3euwA:
20.77
3n5tB-3euwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A  59
GLU A  57
SER A  54
VAL A  52
 None
 1.07A 3n61A-3euwA:
undetectable
3n61B-3euwA:
undetectable		 3n61A-3euwA:
19.86
3n61B-3euwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 PHE A  59
GLU A  57
SER A  54
VAL A  52
 None
 1.09A 3nlrA-3euwA:
undetectable
3nlrB-3euwA:
undetectable		 3nlrA-3euwA:
19.86
3nlrB-3euwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 ARG A 123
PRO A  95
PHE A 121
 None
 0.86A 3thrC-3euwA:
undetectable		 3thrC-3euwA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A 182
PHE A 183
ALA A 131
LEU A 239
 None
 1.09A 4ejgA-3euwA:
undetectable		 4ejgA-3euwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A  59
GLU A  57
SER A  54
VAL A  52
 None
 1.03A 4k5jA-3euwA:
undetectable
4k5jB-3euwA:
undetectable		 4k5jA-3euwA:
20.51
4k5jB-3euwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A  59
GLU A  57
SER A  54
VAL A  52
 None
 1.11A 5adlA-3euwA:
undetectable
5adlB-3euwA:
undetectable		 5adlA-3euwA:
20.51
5adlB-3euwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A  59
GLU A  57
SER A  54
VAL A  52
 None
 1.09A 5fj3A-3euwA:
undetectable
5fj3B-3euwA:
undetectable		 5fj3A-3euwA:
20.51
5fj3B-3euwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A  59
GLU A  57
SER A  54
VAL A  52
 None
 1.05A 5vv7A-3euwA:
undetectable
5vv7B-3euwA:
undetectable		 5vv7A-3euwA:
20.51
5vv7B-3euwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A  59
GLU A  57
SER A  54
VAL A  52
 None
 1.09A 5vvnA-3euwA:
undetectable
5vvnB-3euwA:
undetectable		 5vvnA-3euwA:
20.51
5vvnB-3euwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 GLN A  41
ILE A  13
HIS A  17
 None
 0.61A 5z12B-3euwA:
undetectable		 5z12B-3euwA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 TYR A 235
HIS A 175
MET A 172
 None
 1.12A 6af6A-3euwA:
undetectable		 6af6A-3euwA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 SER A  54
VAL A  52
PHE A  59
GLU A  57
 None
 1.06A 6av6A-3euwA:
undetectable
6av6B-3euwA:
undetectable		 6av6A-3euwA:
14.44
6av6B-3euwA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A  59
GLU A  57
SER A  54
VAL A  52
 None
 1.05A 6av6C-3euwA:
undetectable
6av6D-3euwA:
undetectable		 6av6C-3euwA:
14.44
6av6D-3euwA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 SER A  54
VAL A  52
PHE A  59
GLU A  57
 None
 1.08A 6av7A-3euwA:
undetectable
6av7B-3euwA:
undetectable		 6av7A-3euwA:
14.44
6av7B-3euwA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3euw MYO-INOSITOL
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 VAL A 190
ILE A 225
GLY A 120
ALA A 311
 None
 0.84A 6hd6B-3euwA:
undetectable		 6hd6B-3euwA:
13.62