SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3evz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 8 LYS A 135
LEU A 240
LEU A 202
SER A 154
 None
 0.90A 1dvtA-3evzA:
undetectable
1dvtB-3evzA:
undetectable		 1dvtA-3evzA:
19.64
1dvtB-3evzA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		6 / 12 ILE A  87
GLY A  88
GLY A  90
THR A 110
VAL A 112
PRO A 157
 None
 0.53A 1nv8A-3evzA:
18.0		 1nv8A-3evzA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		6 / 12 ILE A  87
GLY A  88
GLY A  90
THR A 110
VAL A 112
PRO A 157
 None
 0.48A 1nv8B-3evzA:
18.2		 1nv8B-3evzA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 5 SER A 154
PHE A 182
VAL A 200
PHE A  77
 None
 1.49A 1oipA-3evzA:
undetectable		 1oipA-3evzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 GLU A  86
GLY A  88
GLY A  90
ASP A 113
PRO A 157
 None
 0.74A 1qaoA-3evzA:
12.1		 1qaoA-3evzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  87
GLY A  90
THR A 110
VAL A 112
PRO A 157
 None
 0.49A 1sg9A-3evzA:
18.3		 1sg9A-3evzA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  87
GLY A  88
GLY A  90
VAL A 112
PRO A 157
 None
 0.49A 1sg9B-3evzA:
18.2		 1sg9B-3evzA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.03A 1v55C-3evzA:
undetectable
1v55J-3evzA:
undetectable		 1v55C-3evzA:
19.78
1v55J-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.04A 1v55P-3evzA:
undetectable
1v55W-3evzA:
undetectable		 1v55P-3evzA:
19.78
1v55W-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  87
GLY A  90
THR A 110
VAL A 112
PRO A 157
 None
 0.56A 1vq1A-3evzA:
18.3		 1vq1A-3evzA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  87
GLY A  88
GLY A  90
VAL A 112
PRO A 157
 None
 0.51A 1vq1B-3evzA:
18.4		 1vq1B-3evzA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.04A 2eijC-3evzA:
undetectable
2eijJ-3evzA:
undetectable		 2eijC-3evzA:
19.78
2eijJ-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.05A 2einP-3evzA:
undetectable
2einW-3evzA:
undetectable		 2einP-3evzA:
19.78
2einW-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  90
VAL A 112
ASP A 113
PRO A 157
PHE A 182
 None
 1.04A 2f8lA-3evzA:
14.8		 2f8lA-3evzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 0.95A 2zxwC-3evzA:
undetectable
2zxwJ-3evzA:
undetectable		 2zxwC-3evzA:
19.78
2zxwJ-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.05A 3asoP-3evzA:
undetectable
3asoW-3evzA:
undetectable		 3asoP-3evzA:
19.78
3asoW-3evzA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  88
GLY A  90
VAL A 112
SER A 136
ALA A 155
 None
 0.88A 3dh0A-3evzA:
15.9		 3dh0A-3evzA:
30.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 11 GLU A  86
GLY A  88
GLY A  90
GLU A 111
VAL A 112
 None
 0.57A 3dxyA-3evzA:
12.8		 3dxyA-3evzA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 8 SER A 239
PHE A 230
THR A  76
LEU A  74
 None
 0.97A 3ns1L-3evzA:
undetectable		 3ns1L-3evzA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.03A 3wg7C-3evzA:
undetectable
3wg7J-3evzA:
undetectable		 3wg7C-3evzA:
19.78
3wg7J-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 ASN A 123
GLU A  57
GLU A 118
GLU A 125
 None
 1.14A 4mj8C-3evzA:
3.1		 4mj8C-3evzA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 5 LEU A 202
SER A 239
LEU A 211
LEU A 187
 None
 1.25A 4n09B-3evzA:
5.4		 4n09B-3evzA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 5 LEU A 202
SER A 239
LEU A 211
LEU A 187
 None
 1.25A 4n09D-3evzA:
4.8		 4n09D-3evzA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 0.97A 5b1aP-3evzA:
undetectable
5b1aW-3evzA:
undetectable		 5b1aP-3evzA:
19.78
5b1aW-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 0.93A 5b1bP-3evzA:
undetectable
5b1bW-3evzA:
undetectable		 5b1bP-3evzA:
19.78
5b1bW-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 5 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.06A 5iy5P-3evzA:
undetectable
5iy5W-3evzA:
undetectable		 5iy5P-3evzA:
19.49
5iy5W-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.06A 5w97C-3evzA:
undetectable
5w97J-3evzA:
undetectable		 5w97C-3evzA:
19.78
5w97J-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 5 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.13A 5x1fC-3evzA:
undetectable
5x1fJ-3evzA:
undetectable		 5x1fC-3evzA:
19.78
5x1fJ-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 0.96A 5x1fP-3evzA:
undetectable
5x1fW-3evzA:
undetectable		 5x1fP-3evzA:
19.78
5x1fW-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 5 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 0.97A 5xdxC-3evzA:
undetectable
5xdxJ-3evzA:
undetectable		 5xdxC-3evzA:
19.49
5xdxJ-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 5 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.05A 5xdxP-3evzA:
undetectable
5xdxW-3evzA:
undetectable		 5xdxP-3evzA:
19.49
5xdxW-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 PHE A 116
ALA A  93
GLY A  90
GLY A  88
 None
 0.80A 5ybbB-3evzA:
10.9		 5ybbB-3evzA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 0.97A 5zcqC-3evzA:
undetectable
5zcqJ-3evzA:
undetectable		 5zcqC-3evzA:
19.78
5zcqJ-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 0.97A 5zcqP-3evzA:
undetectable
5zcqW-3evzA:
undetectable		 5zcqP-3evzA:
19.78
5zcqW-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 232
GLU A  86
PHE A 153
PRO A 205
ILE A 214
 None
 1.47A 6becA-3evzA:
undetectable
6becB-3evzA:
undetectable
6becC-3evzA:
undetectable		 6becA-3evzA:
16.75
6becB-3evzA:
16.75
6becC-3evzA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 HIS A  91
LEU A  74
PHE A 153
THR A  89
GLY A  90
 None
 1.42A 6brdA-3evzA:
3.8		 6brdA-3evzA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3evz METHYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 GLU A  86
ILE A  87
GLY A  88
GLY A  90
ASP A 113
 None
 0.62A 6iftA-3evzA:
12.4		 6iftA-3evzA:
23.92