SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ew5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		 3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3
(Alphacoronavirus
1) 		5 / 12 PRO A 155
LEU A 173
SER A 169
ILE A 145
SER A 158
 None
None
None
None
1GP  A   9 (-4.8A)
 1.43A 1lbcA-3ew5A:
undetectable
1lbcC-3ew5A:
undetectable		 1lbcA-3ew5A:
23.05
1lbcC-3ew5A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3
(Alphacoronavirus
1) 		3 / 3 GLU A 135
VAL A 168
CYH A 172
 None
 0.99A 3fbxA-3ew5A:
undetectable		 3fbxA-3ew5A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3
(Alphacoronavirus
1) 		4 / 8 ILE A 145
LEU A 122
ALA A  67
ALA A  68
 None
None
1GP  A   9 (-3.4A)
None
 0.73A 3r9tA-3ew5A:
undetectable		 3r9tA-3ew5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3
(Alphacoronavirus
1) 		4 / 7 ILE A 145
LEU A 122
ALA A  67
ALA A  68
 None
None
1GP  A   9 (-3.4A)
None
 0.74A 3r9tB-3ew5A:
undetectable		 3r9tB-3ew5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3
(Alphacoronavirus
1) 		4 / 8 TYR A  48
ASN A 183
PHE A 185
ILE A  56
 None
 0.79A 4eyzA-3ew5A:
undetectable		 4eyzA-3ew5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3
(Alphacoronavirus
1) 		4 / 8 TYR A  48
ASN A 183
PHE A 185
ILE A  56
 None
 0.79A 4eyzB-3ew5A:
undetectable		 4eyzB-3ew5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3
(Alphacoronavirus
1) 		4 / 6 ALA A 124
ASN A 123
LEU A 122
VAL A 121
 None
 0.92A 4g24A-3ew5A:
undetectable		 4g24A-3ew5A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3
(Alphacoronavirus
1) 		4 / 5 GLN A 190
THR A 188
LEU A 170
LEU A 166
 None
 1.03A 4lvcB-3ew5A:
undetectable		 4lvcB-3ew5A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3
(Alphacoronavirus
1) 		4 / 4 GLN A 190
THR A 188
LEU A 170
LEU A 166
 None
 1.03A 5m5kB-3ew5A:
undetectable		 5m5kB-3ew5A:
17.44