SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ewb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 4 THR X 227
LEU X 240
VAL X 243
LEU X 247
 None
 0.95A 1fbmB-3ewbX:
undetectable		 1fbmB-3ewbX:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 4 THR X 227
LEU X 240
VAL X 243
LEU X 247
 None
 0.91A 1fbmD-3ewbX:
undetectable		 1fbmD-3ewbX:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		6 / 12 ILE X 167
GLN X 181
PHE X 183
LEU X 186
CYH X 202
HIS X 201
 None
 1.32A 1fbyA-3ewbX:
undetectable		 1fbyA-3ewbX:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		6 / 12 ILE X 167
GLN X 181
PHE X 183
LEU X 186
CYH X 202
HIS X 201
 None
 1.32A 1fbyB-3ewbX:
undetectable		 1fbyB-3ewbX:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 SER X 273
ASN X 229
ASP X 270
LYS X 266
 None
 1.28A 1hwiC-3ewbX:
undetectable		 1hwiC-3ewbX:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 SER X 273
ASN X 229
ASP X 270
LYS X 266
 None
 1.28A 1hwiD-3ewbX:
undetectable		 1hwiD-3ewbX:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 11 ILE X   4
ALA X 221
ALA X 199
ALA X 216
ILE X 260
 None
 1.07A 2aclE-3ewbX:
undetectable		 2aclE-3ewbX:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 ILE X 165
ILE X 121
LEU X 118
THR X 101
PHE X 149
 None
 1.21A 2qo5A-3ewbX:
undetectable		 2qo5A-3ewbX:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 8 VAL X  41
GLY X  71
THR X  70
ALA X  44
GLU X 225
 None
 0.93A 3aruA-3ewbX:
6.0		 3aruA-3ewbX:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 ILE X 260
GLU X 241
LEU X 262
ASP X 270
SER X 273
 None
 1.15A 3ko0K-3ewbX:
undetectable
3ko0L-3ewbX:
undetectable
3ko0S-3ewbX:
undetectable
3ko0T-3ewbX:
undetectable		 3ko0K-3ewbX:
15.28
3ko0L-3ewbX:
15.28
3ko0S-3ewbX:
15.28
3ko0T-3ewbX:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 8 PHE X 198
GLY X 220
PHE X 183
ILE X 151
PHE X 179
 None
 1.38A 3ko0O-3ewbX:
undetectable
3ko0Q-3ewbX:
undetectable		 3ko0O-3ewbX:
15.28
3ko0Q-3ewbX:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 4 GLY X  45
GLU X  43
ASP X   8
ASP X  53
 None
 1.34A 3mb5A-3ewbX:
undetectable		 3mb5A-3ewbX:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 6 PHE X 265
ASN X 229
ALA X 239
THR X 210
 None
 1.03A 3t3sB-3ewbX:
undetectable		 3t3sB-3ewbX:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 PHE X 265
ASN X 229
ALA X 239
THR X 210
 None
 0.88A 3t3sC-3ewbX:
undetectable		 3t3sC-3ewbX:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 8 PHE X 265
ASN X 229
ALA X 239
THR X 210
 None
 0.97A 3t3sE-3ewbX:
undetectable		 3t3sE-3ewbX:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 ASP X 141
ARG X 234
HIS X 203
HIS X 105
 None
 1.46A 3zodA-3ewbX:
undetectable		 3zodA-3ewbX:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 PHE X 265
ASN X 229
ALA X 239
THR X 210
 None
 0.89A 4ejgA-3ewbX:
undetectable		 4ejgA-3ewbX:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 8 PHE X 265
ASN X 229
ALA X 239
THR X 210
 None
 0.88A 4ejgB-3ewbX:
undetectable		 4ejgB-3ewbX:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 6 PHE X 265
ASN X 229
ALA X 239
THR X 210
 None
 0.90A 4ejgD-3ewbX:
undetectable		 4ejgD-3ewbX:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 ASP X   8
HIS X 203
HIS X 201
GLY X 226
GLY X 236
 None
 1.15A 4lxzA-3ewbX:
undetectable		 4lxzA-3ewbX:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 ASP X   8
HIS X 203
HIS X 201
GLY X 226
GLY X 236
 None
 1.13A 4lxzC-3ewbX:
undetectable		 4lxzC-3ewbX:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 ASP X   8
ILE X 228
GLY X 230
THR X   9
 None
 1.15A 4zxiA-3ewbX:
undetectable		 4zxiA-3ewbX:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		4 / 7 ALA X 142
ILE X 190
PHE X 183
LEU X 186
 None
 0.87A 6b5vA-3ewbX:
undetectable
6b5vB-3ewbX:
undetectable		 6b5vA-3ewbX:
16.43
6b5vB-3ewbX:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 10 LEU X 240
LEU X 247
LYS X 251
ILE X  39
GLY X  38
 None
 1.08A 6dm0B-3ewbX:
2.0
6dm0C-3ewbX:
2.7		 6dm0B-3ewbX:
12.29
6dm0C-3ewbX:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 3ewb 2-ISOPROPYLMALATE
SYNTHASE
(Listeria
monocytogenes) 		5 / 12 VAL X 134
THR X 101
VAL X  41
GLU X  43
GLY X  71
 None
 1.45A 6gngB-3ewbX:
undetectable		 6gngB-3ewbX:
18.77