SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ewi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE
(Mus
musculus) 		3 / 3 ALA A  86
VAL A  88
TRP A  91
 None
 0.83A 1av2C-3ewiA:
undetectable
1av2D-3ewiA:
undetectable		 1av2C-3ewiA:
12.50
1av2D-3ewiA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A  48
PHE A 156
ARG A 149
GLY A  44
ILE A 148
 None
 1.12A 1kglA-3ewiA:
undetectable		 1kglA-3ewiA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE
(Mus
musculus) 		3 / 3 ALA A  86
VAL A  88
TRP A  91
 None
 0.81A 1w5uC-3ewiA:
undetectable
1w5uD-3ewiA:
undetectable		 1w5uC-3ewiA:
12.50
1w5uD-3ewiA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE
(Mus
musculus) 		4 / 5 ILE A 138
LEU A 105
ALA A 147
GLU A 150
 None
 1.24A 1xvaA-3ewiA:
2.5
1xvaB-3ewiA:
2.7		 1xvaA-3ewiA:
21.16
1xvaB-3ewiA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE
(Mus
musculus) 		4 / 5 TYR A  26
ILE A  25
ARG A 145
GLY A 144
 None
 1.22A 2du8G-3ewiA:
4.4		 2du8G-3ewiA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE
(Mus
musculus) 		4 / 5 TYR A  26
ILE A  25
ARG A 145
GLY A 144
 None
 1.24A 2du8J-3ewiA:
4.5		 2du8J-3ewiA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE
(Mus
musculus) 		3 / 3 TRP A  91
ALA A  86
VAL A  88
 None
 0.81A 2izqA-3ewiA:
undetectable
2izqB-3ewiA:
undetectable		 2izqA-3ewiA:
12.50
2izqB-3ewiA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE
(Mus
musculus) 		4 / 6 LEU A  20
ILE A  45
ILE A 159
LEU A 120
 None
 0.75A 2xkwB-3ewiA:
undetectable		 2xkwB-3ewiA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE
(Mus
musculus) 		3 / 3 CYH A 128
PRO A 124
ASP A 111
 None
 0.98A 3hlwB-3ewiA:
undetectable		 3hlwB-3ewiA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE
(Mus
musculus) 		3 / 3 ALA A  86
VAL A  88
TRP A  91
 None
 0.82A 3l8lA-3ewiA:
undetectable
3l8lB-3ewiA:
undetectable		 3l8lA-3ewiA:
12.50
3l8lB-3ewiA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE
(Mus
musculus) 		3 / 3 ALA A  86
VAL A  88
TRP A  91
 None
 0.81A 3l8lC-3ewiA:
undetectable
3l8lD-3ewiA:
undetectable		 3l8lC-3ewiA:
12.50
3l8lD-3ewiA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE
(Mus
musculus) 		4 / 6 GLY A 143
ASP A 126
GLY A  23
SER A 110
 None
 1.04A 4z53A-3ewiA:
undetectable
4z53B-3ewiA:
undetectable		 4z53A-3ewiA:
13.78
4z53B-3ewiA:
13.78