SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ewk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3ewk SENSOR PROTEIN
(Methylococcus
capsulatus) 		5 / 11 LEU A 250
GLY A 251
ILE A 256
SER A 253
THR A 225
 None
 1.26A 3bjwH-3ewkA:
undetectable		 3bjwH-3ewkA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3ewk SENSOR PROTEIN
(Methylococcus
capsulatus) 		4 / 6 ALA A 262
ASP A 258
LEU A 267
THR A 266
 None
 1.04A 3rozA-3ewkA:
undetectable		 3rozA-3ewkA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3ewk SENSOR PROTEIN
(Methylococcus
capsulatus) 		4 / 8 ASN A 286
ARG A 288
LEU A 238
ILE A 231
 None
 1.01A 4l7iA-3ewkA:
undetectable		 4l7iA-3ewkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3ewk SENSOR PROTEIN
(Methylococcus
capsulatus) 		3 / 3 ARG A 288
ASP A 299
ARG A 287
 None
 0.60A 4wq4B-3ewkA:
undetectable		 4wq4B-3ewkA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 3ewk SENSOR PROTEIN
(Methylococcus
capsulatus) 		4 / 5 HIS A 132
ILE A 109
SER A 193
ALA A 112
 FAD  A 326 (-3.4A)
None
FAD  A 326 ( 4.1A)
None
 1.26A 5msdA-3ewkA:
undetectable		 5msdA-3ewkA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3ewk SENSOR PROTEIN
(Methylococcus
capsulatus) 		4 / 7 ALA A 228
GLY A 229
LEU A 274
GLY A 315
 None
 0.74A 6nm4A-3ewkA:
undetectable		 6nm4A-3ewkA:
20.26