SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ewn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3ewn THIJ/PFPI FAMILY
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 GLY A 122
ASP A  68
GLY A 204
SER A 152
 None
GOL  A3968 ( 4.7A)
None
None
 0.78A 1eswA-3ewnA:
undetectable		 1eswA-3ewnA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3ewn THIJ/PFPI FAMILY
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 LEU A 165
ALA A 162
LEU A 160
SER A 157
 None
 1.06A 1tt6B-3ewnA:
undetectable		 1tt6B-3ewnA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3ewn THIJ/PFPI FAMILY
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 PHE A 211
LEU A 160
GLU A 218
ARG A 195
 None
 1.02A 2jn3A-3ewnA:
undetectable		 2jn3A-3ewnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 3ewn THIJ/PFPI FAMILY
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLN A 229
ALA A 228
ASP A 210
GLY A  71
LEU A 213
 None
 1.21A 2nv4A-3ewnA:
undetectable		 2nv4A-3ewnA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3ewn THIJ/PFPI FAMILY
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 LEU A 181
LEU A 166
ALA A 271
ALA A 131
 None
 0.82A 2vcvP-3ewnA:
undetectable		 2vcvP-3ewnA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 3ewn THIJ/PFPI FAMILY
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 THR A 124
CYH A 154
GLY A 122
ASP A  68
 GOL  A3968 (-4.6A)
GOL  A3968 (-3.6A)
None
GOL  A3968 ( 4.7A)
 1.33A 3w9tE-3ewnA:
undetectable		 3w9tE-3ewnA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3ewn THIJ/PFPI FAMILY
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 SER A 155
LEU A 165
ALA A 162
LEU A 160
 GOL  A3968 (-3.6A)
None
None
None
 0.98A 4iklA-3ewnA:
undetectable
4iklB-3ewnA:
undetectable		 4iklA-3ewnA:
22.49
4iklB-3ewnA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 3ewn THIJ/PFPI FAMILY
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 THR A 264
ALA A 267
ASP A 268
LEU A 158
GLY A 204
 None
 0.76A 4xi3B-3ewnA:
undetectable		 4xi3B-3ewnA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ewn THIJ/PFPI FAMILY
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 PHE A  76
ILE A  56
PHE A 211
LEU A 160
 None
 0.86A 4ze3A-3ewnA:
undetectable		 4ze3A-3ewnA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ewn THIJ/PFPI FAMILY
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 PHE A  76
ILE A  56
PHE A 211
LEU A 160
 None
 0.91A 5esjA-3ewnA:
undetectable		 5esjA-3ewnA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3ewn THIJ/PFPI FAMILY
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 9 LEU A 128
SER A 157
GLY A 161
PHE A 184
PHE A 263
 None
None
None
None
GOL  A3968 (-3.9A)
 1.23A 6ebpA-3ewnA:
undetectable		 6ebpA-3ewnA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3ewn THIJ/PFPI FAMILY
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 LEU A 128
SER A 157
GLY A 161
PHE A 184
PHE A 263
 None
None
None
None
GOL  A3968 (-3.9A)
 1.24A 6ebpB-3ewnA:
undetectable		 6ebpB-3ewnA:
14.48