SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ewr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_E_ACTE3005_0 (BETA-CARBONIC ANHYDRASE)	3ewr	NON-STRUCTURAL PROTEIN 3 (Human coronavirus 229E)	4 / 7	ASP A 51 GLY A 43 GLY A 44 GLN A 59	None APR A 169 ( 4.5A) APR A 169 (-3.2A) None	0.99A	1ekjE-3ewrA: undetectable 1ekjF-3ewrA: undetectable	1ekjE-3ewrA: 20.96 1ekjF-3ewrA: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_A_HSMA1161_1 (ALLERGEN ARG R 1)	3ewr	NON-STRUCTURAL PROTEIN 3 (Human coronavirus 229E)	4 / 5	VAL A 52 TYR A 53 VAL A 20 ASP A 19	None None APR A 169 (-4.3A) None	1.29A	2x45A-3ewrA: undetectable	2x45A-3ewrA: 18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_C_HSMC1161_1 (ALLERGEN ARG R 1)	3ewr	NON-STRUCTURAL PROTEIN 3 (Human coronavirus 229E)	4 / 5	VAL A 52 TYR A 53 VAL A 20 ASP A 19	None None APR A 169 (-4.3A) None	1.33A	2x45C-3ewrA: undetectable	2x45C-3ewrA: 18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3M6V_A_SAMA465_0 (RRNA METHYLASE)	3ewr	NON-STRUCTURAL PROTEIN 3 (Human coronavirus 229E)	5 / 12	GLY A 44 GLY A 43 ASP A 19 ASP A 51 LEU A 85	APR A 169 (-3.2A) APR A 169 ( 4.5A) None None None	0.96A	3m6vA-3ewrA: undetectable	3m6vA-3ewrA: 16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3M6V_B_SAMB465_0 (RRNA METHYLASE)	3ewr	NON-STRUCTURAL PROTEIN 3 (Human coronavirus 229E)	5 / 12	GLY A 44 GLY A 43 ASP A 19 ASP A 51 LEU A 85	APR A 169 (-3.2A) APR A 169 ( 4.5A) None None None	0.98A	3m6vB-3ewrA: undetectable	3m6vB-3ewrA: 16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_A_ZPCA1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3ewr	NON-STRUCTURAL PROTEIN 3 (Human coronavirus 229E)	4 / 7	PHE A 7 TYR A 16 VAL A 151 ILE A 121	None None APR A 169 ( 4.6A) None	0.94A	4a97E-3ewrA: undetectable	4a97E-3ewrA: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_D_ZPCD1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3ewr	NON-STRUCTURAL PROTEIN 3 (Human coronavirus 229E)	4 / 8	PHE A 7 TYR A 16 VAL A 151 ILE A 121	None None APR A 169 ( 4.6A) None	0.94A	4a97C-3ewrA: undetectable	4a97C-3ewrA: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_E_ZPCE1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3ewr	NON-STRUCTURAL PROTEIN 3 (Human coronavirus 229E)	4 / 8	PHE A 7 TYR A 16 VAL A 151 ILE A 121	None None APR A 169 ( 4.6A) None	0.93A	4a97D-3ewrA: undetectable	4a97D-3ewrA: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_H_ZPCH1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3ewr	NON-STRUCTURAL PROTEIN 3 (Human coronavirus 229E)	4 / 8	PHE A 7 TYR A 16 VAL A 151 ILE A 121	None None APR A 169 ( 4.6A) None	0.90A	4a97G-3ewrA: undetectable	4a97G-3ewrA: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_I_ZPCI1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3ewr	NON-STRUCTURAL PROTEIN 3 (Human coronavirus 229E)	4 / 7	PHE A 7 TYR A 16 VAL A 151 ILE A 121	None None APR A 169 ( 4.6A) None	0.93A	4a97H-3ewrA: undetectable	4a97H-3ewrA: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_J_ZPCJ1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3ewr	NON-STRUCTURAL PROTEIN 3 (Human coronavirus 229E)	4 / 8	PHE A 7 TYR A 16 VAL A 151 ILE A 121	None None APR A 169 ( 4.6A) None	0.94A	4a97I-3ewrA: undetectable	4a97I-3ewrA: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YJI_A_TYLA502_1 (ARYL ACYLAMIDASE)	3ewr	NON-STRUCTURAL PROTEIN 3 (Human coronavirus 229E)	4 / 7	GLY A 43 GLY A 44 ALA A 47 ILE A 126	APR A 169 ( 4.5A) APR A 169 (-3.2A) APR A 169 (-3.4A) APR A 169 (-3.5A)	0.45A	4yjiA-3ewrA: undetectable	4yjiA-3ewrA: 14.47

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EKJ_E_ACTE3005_0","BETA-CARBONIC ANHYDRASE","3ewr","NON-STRUCTURAL PROTEIN 3","Human coronavirus 229E",4,"ASP A  51;GLY A  43;GLY A  44;GLN A  59","None;APR A 169 ( 4.5A);APR A 169 (-3.2A);None","0.99A","1ekjE-3ewrA:undetectable;1ekjF-3ewrA:undetectable","1ekjE-3ewrA:20.96;1ekjF-3ewrA:20.96"],["2X45_A_HSMA1161_1","ALLERGEN ARG R 1","3ewr","NON-STRUCTURAL PROTEIN 3","Human coronavirus 229E",4,"VAL A  52;TYR A  53;VAL A  20;ASP A  19","None;None;APR A 169 (-4.3A);None","1.29A","2x45A-3ewrA:undetectable","2x45A-3ewrA:18.39"],["2X45_C_HSMC1161_1","ALLERGEN ARG R 1","3ewr","NON-STRUCTURAL PROTEIN 3","Human coronavirus 229E",4,"VAL A  52;TYR A  53;VAL A  20;ASP A  19","None;None;APR A 169 (-4.3A);None","1.33A","2x45C-3ewrA:undetectable","2x45C-3ewrA:18.39"],["3M6V_A_SAMA465_0","RRNA METHYLASE","3ewr","NON-STRUCTURAL PROTEIN 3","Human coronavirus 229E",5,"GLY A  44;GLY A  43;ASP A  19;ASP A  51;LEU A  85","APR A 169 (-3.2A);APR A 169 ( 4.5A);None;None;None","0.96A","3m6vA-3ewrA:undetectable","3m6vA-3ewrA:16.96"],["3M6V_B_SAMB465_0","RRNA METHYLASE","3ewr","NON-STRUCTURAL PROTEIN 3","Human coronavirus 229E",5,"GLY A  44;GLY A  43;ASP A  19;ASP A  51;LEU A  85","APR A 169 (-3.2A);APR A 169 ( 4.5A);None;None;None","0.98A","3m6vB-3ewrA:undetectable","3m6vB-3ewrA:16.96"],["4A97_A_ZPCA1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3ewr","NON-STRUCTURAL PROTEIN 3","Human coronavirus 229E",4,"PHE A   7;TYR A  16;VAL A 151;ILE A 121","None;None;APR A 169 ( 4.6A);None","0.94A","4a97E-3ewrA:undetectable","4a97E-3ewrA:19.29"],["4A97_D_ZPCD1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3ewr","NON-STRUCTURAL PROTEIN 3","Human coronavirus 229E",4,"PHE A   7;TYR A  16;VAL A 151;ILE A 121","None;None;APR A 169 ( 4.6A);None","0.94A","4a97C-3ewrA:undetectable","4a97C-3ewrA:19.29"],["4A97_E_ZPCE1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3ewr","NON-STRUCTURAL PROTEIN 3","Human coronavirus 229E",4,"PHE A   7;TYR A  16;VAL A 151;ILE A 121","None;None;APR A 169 ( 4.6A);None","0.93A","4a97D-3ewrA:undetectable","4a97D-3ewrA:19.29"],["4A97_H_ZPCH1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3ewr","NON-STRUCTURAL PROTEIN 3","Human coronavirus 229E",4,"PHE A   7;TYR A  16;VAL A 151;ILE A 121","None;None;APR A 169 ( 4.6A);None","0.90A","4a97G-3ewrA:undetectable","4a97G-3ewrA:19.29"],["4A97_I_ZPCI1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3ewr","NON-STRUCTURAL PROTEIN 3","Human coronavirus 229E",4,"PHE A   7;TYR A  16;VAL A 151;ILE A 121","None;None;APR A 169 ( 4.6A);None","0.93A","4a97H-3ewrA:undetectable","4a97H-3ewrA:19.29"],["4A97_J_ZPCJ1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3ewr","NON-STRUCTURAL PROTEIN 3","Human coronavirus 229E",4,"PHE A   7;TYR A  16;VAL A 151;ILE A 121","None;None;APR A 169 ( 4.6A);None","0.94A","4a97I-3ewrA:undetectable","4a97I-3ewrA:19.29"],["4YJI_A_TYLA502_1","ARYL ACYLAMIDASE","3ewr","NON-STRUCTURAL PROTEIN 3","Human coronavirus 229E",4,"GLY A  43;GLY A  44;ALA A  47;ILE A 126","APR A 169 ( 4.5A);APR A 169 (-3.2A);APR A 169 (-3.4A);APR A 169 (-3.5A)","0.45A","4yjiA-3ewrA:undetectable","4yjiA-3ewrA:14.47"]]