SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3exh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU B 288
THR B 261
THR B 208
VAL B 210
 None
 0.67A 1ictD-3exhB:
undetectable		 1ictD-3exhB:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR B 256
ALA B 284
ALA B 292
THR B 261
VAL B 210
 None
 1.22A 2ve3B-3exhB:
undetectable		 2ve3B-3exhB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 VAL B 168
ILE B 157
GLY B  12
ARG B  19
 None
 0.92A 3bjwH-3exhB:
undetectable		 3bjwH-3exhB:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG B  19
ILE B 157
THR B 240
 None
 0.54A 3ia4D-3exhB:
undetectable		 3ia4D-3exhB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 GLY B  27
ILE B 112
PHE B  80
GLY B 116
PHE B  83
 None
 1.41A 3ko0A-3exhB:
undetectable
3ko0C-3exhB:
undetectable		 3ko0A-3exhB:
15.34
3ko0C-3exhB:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 GLY B  27
ILE B 112
PHE B  80
GLY B 116
PHE B  83
 None
 1.44A 3ko0R-3exhB:
undetectable
3ko0T-3exhB:
undetectable		 3ko0R-3exhB:
15.34
3ko0T-3exhB:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 HIS B 212
SER B 211
GLU B 263
ASP B 299
 None
 1.44A 3tm4A-3exhB:
2.2		 3tm4A-3exhB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 HIS B 212
SER B 211
GLU B 263
ASP B 299
 None
 1.44A 3tm4B-3exhB:
2.3		 3tm4B-3exhB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LEU B 308
MET B 302
ASP B 299
 None
 0.79A 3v5wA-3exhB:
undetectable		 3v5wA-3exhB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ILE B 241
VAL B 169
VAL B 144
ARG B 242
 None
 1.16A 4m6tA-3exhB:
undetectable		 4m6tA-3exhB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_0
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU B 171
PRO B 117
ILE B 193
GLU B 173
TYR B  37
 None
 1.28A 4rfqA-3exhB:
0.0		 4rfqA-3exhB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 SER B 252
ARG B 278
GLY B 282
GLU B 281
 None
 1.13A 5btiC-3exhB:
undetectable
5btiD-3exhB:
6.5		 5btiC-3exhB:
21.14
5btiD-3exhB:
22.10