SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 6 LEU A 130
ILE A   9
TYR A 127
VAL A 163
 None
 1.13A 1db1A-3eyaA:
undetectable		 1db1A-3eyaA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		6 / 12 ILE A 455
ALA A 411
ASP A 379
LEU A 362
PRO A 359
VAL A 527
 None
 1.19A 1df7A-3eyaA:
undetectable		 1df7A-3eyaA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 11 ILE A 455
ALA A 411
ASP A 379
LEU A 362
PRO A 359
 None
 1.19A 1dg5A-3eyaA:
undetectable		 1dg5A-3eyaA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		3 / 4 LYS A  11
ALA A  10
MET A  39
 None
 0.91A 1hk3A-3eyaA:
undetectable		 1hk3A-3eyaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 11 ASP A 433
GLY A 434
GLY A 381
PRO A 359
VAL A 527
 MG  A 613 ( 2.7A)
TDP  A 611 (-3.3A)
TDP  A 611 (-3.4A)
None
None
 1.01A 1hxwB-3eyaA:
undetectable		 1hxwB-3eyaA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 10 GLU A  51
LEU A 439
ALA A  56
PHE A  55
GLY A  58
 None
 1.37A 1mjqC-3eyaA:
undetectable
1mjqD-3eyaA:
undetectable		 1mjqC-3eyaA:
10.79
1mjqD-3eyaA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 5 LEU A  32
ALA A 164
LEU A  29
SER A  28
 None
None
None
PO4  A 614 (-2.7A)
 0.93A 1tt6B-3eyaA:
undetectable		 1tt6B-3eyaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 12 LEU A 130
GLY A 161
SER A 105
ALA A 164
ALA A   6
 None
 1.18A 2bm9D-3eyaA:
2.5		 2bm9D-3eyaA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		6 / 12 LEU A  85
GLY A  72
ALA A  71
VAL A  69
VAL A 158
VAL A 154
 None
 1.30A 2o4lB-3eyaA:
undetectable		 2o4lB-3eyaA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 6 PHE A 331
PRO A 283
LEU A 269
ALA A 205
 None
 0.96A 2vcvB-3eyaA:
undetectable		 2vcvB-3eyaA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		3 / 3 GLU A  66
GLN A  62
ARG A 398
 None
 0.88A 2w3bB-3eyaA:
undetectable		 2w3bB-3eyaA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 12 LEU A 482
ASP A 379
VAL A 380
PHE A  55
ASN A  83
 None
None
FAD  A 612 ( 3.8A)
None
None
 1.48A 2y00B-3eyaA:
undetectable		 2y00B-3eyaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 6 LEU A  32
ALA A 164
LEU A  29
SER A  28
 None
None
None
PO4  A 614 (-2.7A)
 1.04A 3cfqA-3eyaA:
undetectable		 3cfqA-3eyaA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 7 LEU A  32
ALA A 164
LEU A  29
SER A  28
 None
None
None
PO4  A 614 (-2.7A)
 1.02A 3cfqA-3eyaA:
undetectable
3cfqB-3eyaA:
undetectable		 3cfqA-3eyaA:
12.64
3cfqB-3eyaA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 7 LEU A  32
ALA A 164
LEU A  29
SER A  28
VAL A 131
 None
None
None
PO4  A 614 (-2.7A)
None
 1.21A 3d2tA-3eyaA:
undetectable		 3d2tA-3eyaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 11 ASP A 433
GLY A 434
GLY A 381
PRO A 359
VAL A 527
 MG  A 613 ( 2.7A)
TDP  A 611 (-3.3A)
TDP  A 611 (-3.4A)
None
None
 1.03A 3el1A-3eyaA:
undetectable		 3el1A-3eyaA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 12 VAL A  52
ASP A 442
ILE A 455
VAL A 457
CYH A 431
 None
 1.42A 3p6gA-3eyaA:
undetectable		 3p6gA-3eyaA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 5 GLY A 249
ASP A 247
ARG A 343
MET A 430
 None
None
PO4  A 616 (-3.7A)
None
 1.37A 3qx3A-3eyaA:
undetectable		 3qx3A-3eyaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 5 GLY A 249
ASP A 247
ARG A 343
MET A 430
 None
None
PO4  A 616 (-3.7A)
None
 1.42A 3qx3B-3eyaA:
undetectable		 3qx3B-3eyaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 10 VAL A 427
GLY A 417
ALA A 418
ALA A  59
THR A 377
 None
 0.92A 3ucjA-3eyaA:
undetectable		 3ucjA-3eyaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 10 VAL A 427
GLY A 417
ALA A 418
ALA A  59
THR A 377
 None
 0.92A 3ucjB-3eyaA:
undetectable		 3ucjB-3eyaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 10 LEU A  13
LEU A  36
LEU A  29
ASN A  30
ILE A  21
 None
 1.16A 3wdmD-3eyaA:
10.4		 3wdmD-3eyaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 8 TYR A 200
MET A 306
ILE A 289
GLU A 324
 None
 1.07A 4a97G-3eyaA:
undetectable		 4a97G-3eyaA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 8 TYR A 200
MET A 306
ILE A 289
GLU A 324
 None
 1.02A 4a97I-3eyaA:
undetectable		 4a97I-3eyaA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 6 LEU A  32
ALA A 164
LEU A  29
SER A  28
 None
None
None
PO4  A 614 (-2.7A)
 0.88A 4i89A-3eyaA:
undetectable		 4i89A-3eyaA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 5 LYS A 193
LEU A 194
GLU A 190
LEU A 308
 None
 0.97A 4k4yA-3eyaA:
undetectable		 4k4yA-3eyaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 4 LYS A 193
LEU A 194
GLU A 190
LEU A 308
 None
 0.99A 4k4yE-3eyaA:
undetectable		 4k4yE-3eyaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 5 LYS A 193
LEU A 194
GLU A 190
LEU A 308
 None
 1.00A 4k4yI-3eyaA:
undetectable		 4k4yI-3eyaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		3 / 3 ASP A 379
TRP A  22
SER A 407
 None
None
TDP  A 611 ( 4.0A)
 1.03A 4lrhA-3eyaA:
undetectable		 4lrhA-3eyaA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		3 / 3 SER A  73
ALA A  99
VAL A 158
 PO4  A 614 ( 3.9A)
None
None
 0.59A 4o2bA-3eyaA:
undetectable		 4o2bA-3eyaA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		3 / 3 SER A  73
ALA A  99
VAL A 158
 PO4  A 614 ( 3.9A)
None
None
 0.54A 4o2bC-3eyaA:
2.8		 4o2bC-3eyaA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 12 LEU A 272
LEU A 332
ILE A 226
ILE A 204
VAL A 248
 None
 1.17A 4y0pA-3eyaA:
undetectable		 4y0pA-3eyaA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 10 ALA A 228
LEU A 269
ALA A 266
LEU A 336
ALA A 335
 None
 1.18A 4zbrA-3eyaA:
undetectable		 4zbrA-3eyaA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 7 MET A 438
HIS A 405
GLY A  84
ASN A  83
 TDP  A 611 ( 3.7A)
None
None
None
 1.16A 5a5zC-3eyaA:
undetectable		 5a5zC-3eyaA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 6 LEU A  32
ALA A 164
LEU A  29
SER A  28
 None
None
None
PO4  A 614 (-2.7A)
 0.88A 5bojA-3eyaA:
undetectable		 5bojA-3eyaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		6 / 12 SER A 210
GLY A 211
GLY A 209
VAL A 304
ASP A 292
ILE A 298
 FAD  A 612 (-2.6A)
FAD  A 612 (-3.4A)
FAD  A 612 (-3.2A)
None
FAD  A 612 (-2.8A)
None
 1.49A 5ec8A-3eyaA:
2.4		 5ec8A-3eyaA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 12 ILE A 455
GLU A 422
ALA A  57
ALA A  56
VAL A  52
 None
 1.43A 5igpA-3eyaA:
undetectable		 5igpA-3eyaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 12 ALA A  56
LEU A 416
ALA A  71
GLY A  23
SER A  46
 None
 1.11A 5jglB-3eyaA:
undetectable		 5jglB-3eyaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 6 LEU A  32
ALA A 164
LEU A  29
SER A  28
 None
None
None
PO4  A 614 (-2.7A)
 0.85A 5l4iA-3eyaA:
undetectable		 5l4iA-3eyaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 10 ALA A 144
LEU A 141
VAL A 140
LEU A  13
ILE A  98
 None
 1.12A 5v02B-3eyaA:
undetectable
5v02R-3eyaA:
undetectable		 5v02B-3eyaA:
11.52
5v02R-3eyaA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 12 GLN A 414
ALA A  56
LEU A 400
ILE A 375
ARG A 425
 None
 1.11A 5vlmG-3eyaA:
undetectable		 5vlmG-3eyaA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 5 GLY A 249
ASP A 247
ARG A 343
MET A 430
 None
None
PO4  A 616 (-3.7A)
None
 1.42A 5zrfB-3eyaA:
2.4		 5zrfB-3eyaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 4 GLY A 249
ASP A 247
ARG A 343
MET A 430
 None
None
PO4  A 616 (-3.7A)
None
 1.43A 5zrfA-3eyaA:
undetectable		 5zrfA-3eyaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 9 ILE A 312
ALA A 215
GLY A 214
TYR A 242
CYH A 208
 FAD  A 612 (-4.4A)
None
None
None
None
 0.99A 6nm4B-3eyaA:
undetectable		 6nm4B-3eyaA:
15.17