SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eyx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		5 / 8 CYH A  57
ASP A  59
HIS A 112
CYH A 115
GLY A 116
 ZN  A   1 ( 2.3A)
ZN  A   1 ( 4.8A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 2.2A)
ACT  A 222 (-3.2A)
 1.04A 1ekjA-3eyxA:
21.3
1ekjB-3eyxA:
21.2		 1ekjA-3eyxA:
29.36
1ekjB-3eyxA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		6 / 8 CYH A  57
ASP A  59
HIS A 112
CYH A 115
GLY A 116
GLY A 117
 ZN  A   1 ( 2.3A)
ZN  A   1 ( 4.8A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 2.2A)
ACT  A 222 (-3.2A)
ACT  A 222 (-3.6A)
 0.40A 1ekjA-3eyxA:
21.3
1ekjB-3eyxA:
21.2		 1ekjA-3eyxA:
29.36
1ekjB-3eyxA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		6 / 8 CYH A  57
ASP A  59
VAL A  80
HIS A 112
CYH A 115
GLY A 116
 ZN  A   1 ( 2.3A)
ZN  A   1 ( 4.8A)
ACT  A 222 (-4.2A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 2.2A)
ACT  A 222 (-3.2A)
 0.30A 1ekjA-3eyxA:
21.3
1ekjB-3eyxA:
21.2		 1ekjA-3eyxA:
29.36
1ekjB-3eyxA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		5 / 8 CYH A  57
VAL A  80
HIS A 112
CYH A 115
GLY A 117
 ZN  A   1 ( 2.3A)
ACT  A 222 (-4.2A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 2.2A)
ACT  A 222 (-3.6A)
 1.04A 1ekjA-3eyxA:
21.3
1ekjB-3eyxA:
21.2		 1ekjA-3eyxA:
29.36
1ekjB-3eyxA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		4 / 6 CYH A  57
ASP A  59
VAL A  80
GLY A 116
 ZN  A   1 ( 2.3A)
ZN  A   1 ( 4.8A)
ACT  A 222 (-4.2A)
ACT  A 222 (-3.2A)
 0.22A 1ekjC-3eyxA:
21.4
1ekjD-3eyxA:
21.4		 1ekjC-3eyxA:
29.36
1ekjD-3eyxA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		4 / 6 CYH A  57
ASP A  59
VAL A  80
GLY A 116
 ZN  A   1 ( 2.3A)
ZN  A   1 ( 4.8A)
ACT  A 222 (-4.2A)
ACT  A 222 (-3.2A)
 0.20A 1ekjC-3eyxA:
21.4
1ekjD-3eyxA:
21.4		 1ekjC-3eyxA:
29.36
1ekjD-3eyxA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		5 / 7 CYH A  57
ASP A  59
HIS A 112
GLY A 116
GLY A 117
 ZN  A   1 ( 2.3A)
ZN  A   1 ( 4.8A)
ZN  A   1 (-3.2A)
ACT  A 222 (-3.2A)
ACT  A 222 (-3.6A)
 0.33A 1ekjE-3eyxA:
21.3
1ekjF-3eyxA:
21.3		 1ekjE-3eyxA:
29.36
1ekjF-3eyxA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		5 / 8 CYH A  57
ASP A  59
VAL A  80
GLY A 116
GLY A 117
 ZN  A   1 ( 2.3A)
ZN  A   1 ( 4.8A)
ACT  A 222 (-4.2A)
ACT  A 222 (-3.2A)
ACT  A 222 (-3.6A)
 0.43A 1ekjE-3eyxA:
21.3
1ekjF-3eyxA:
21.3		 1ekjE-3eyxA:
29.36
1ekjF-3eyxA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		5 / 8 CYH A  57
ASP A  59
HIS A 112
CYH A 115
GLY A 116
 ZN  A   1 ( 2.3A)
ZN  A   1 ( 4.8A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 2.2A)
ACT  A 222 (-3.2A)
 1.01A 1ekjG-3eyxA:
21.4
1ekjH-3eyxA:
18.7		 1ekjG-3eyxA:
29.36
1ekjH-3eyxA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		6 / 8 CYH A  57
ASP A  59
HIS A 112
CYH A 115
GLY A 116
GLY A 117
 ZN  A   1 ( 2.3A)
ZN  A   1 ( 4.8A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 2.2A)
ACT  A 222 (-3.2A)
ACT  A 222 (-3.6A)
 0.34A 1ekjG-3eyxA:
21.4
1ekjH-3eyxA:
18.7		 1ekjG-3eyxA:
29.36
1ekjH-3eyxA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		5 / 6 CYH A  57
ASP A  59
VAL A  80
HIS A 112
CYH A 115
 ZN  A   1 ( 2.3A)
ZN  A   1 ( 4.8A)
ACT  A 222 (-4.2A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 2.2A)
 0.26A 1ekjG-3eyxA:
21.4
1ekjH-3eyxA:
18.7		 1ekjG-3eyxA:
29.36
1ekjH-3eyxA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  67
PHE A  54
ARG A  61
 None
 0.87A 1xdkB-3eyxA:
undetectable		 1xdkB-3eyxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A  81
TYR A 140
ASN A  82
GLY A 117
ILE A 144
 ACT  A 222 (-3.8A)
None
None
ACT  A 222 (-3.6A)
None
 1.48A 2zmaA-3eyxA:
undetectable		 2zmaA-3eyxA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		6 / 10 CYH A  57
ASP A  59
VAL A  80
HIS A 112
CYH A 115
GLY A 116
 ZN  A   1 ( 2.3A)
ZN  A   1 ( 4.8A)
ACT  A 222 (-4.2A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 2.2A)
ACT  A 222 (-3.2A)
 0.22A 3ucjA-3eyxA:
23.1		 3ucjA-3eyxA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		5 / 10 CYH A  57
VAL A  80
HIS A 112
CYH A 115
GLY A 117
 ZN  A   1 ( 2.3A)
ACT  A 222 (-4.2A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 2.2A)
ACT  A 222 (-3.6A)
 0.99A 3ucjA-3eyxA:
23.1		 3ucjA-3eyxA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		6 / 10 CYH A  57
ASP A  59
VAL A  80
HIS A 112
CYH A 115
GLY A 116
 ZN  A   1 ( 2.3A)
ZN  A   1 ( 4.8A)
ACT  A 222 (-4.2A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 2.2A)
ACT  A 222 (-3.2A)
 0.26A 3ucjB-3eyxA:
23.8		 3ucjB-3eyxA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		5 / 10 CYH A  57
VAL A  80
HIS A 112
CYH A 115
GLY A 117
 ZN  A   1 ( 2.3A)
ACT  A 222 (-4.2A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 2.2A)
ACT  A 222 (-3.6A)
 0.99A 3ucjB-3eyxA:
23.8		 3ucjB-3eyxA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 3eyx CARBONIC ANHYDRASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 201
GLY A 199
TYR A 198
HIS A 112
TYR A  62
 None
None
None
ZN  A   1 (-3.2A)
None
 1.41A 5tqrB-3eyxA:
undetectable		 5tqrB-3eyxA:
12.63