SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eyy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OE2_A_CUA502_0 (DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE)	3eyy	PUTATIVE IRON UPTAKE REGULATORY PROTEIN (Streptomyces coelicolor)	3 / 3	GLU A 101 HIS A 90 HIS A 88	ZN A 147 ( 4.0A) ZN A 147 (-3.3A) ZN A 147 (-3.7A)	0.67A	1oe2A-3eyyA: undetectable	1oe2A-3eyyA: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WKO_A_CUA154_0 (SUPEROXIDE DISMUTASE [CU-ZN])	3eyy	PUTATIVE IRON UPTAKE REGULATORY PROTEIN (Streptomyces coelicolor)	4 / 4	HIS A 86 HIS A 90 HIS A 88 HIS A 33	ZN A 147 (-3.3A) ZN A 147 (-3.3A) ZN A 147 (-3.7A) ZN A 147 (-3.3A)	1.00A	2wkoA-3eyyA: undetectable	2wkoA-3eyyA: 19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA504_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	3eyy	PUTATIVE IRON UPTAKE REGULATORY PROTEIN (Streptomyces coelicolor)	4 / 8	LEU A 23 ILE A 50 THR A 54 THR A 58	None	0.70A	4em2A-3eyyA: 6.5	4em2A-3eyyA: 22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVR_A_SALA203_1 (3-HYDROXYANTHRANILAT E 3,4-DIOXYGENASE)	3eyy	PUTATIVE IRON UPTAKE REGULATORY PROTEIN (Streptomyces coelicolor)	4 / 7	HIS A 86 GLU A 101 HIS A 88 VAL A 99	ZN A 147 (-3.3A) ZN A 147 ( 4.0A) ZN A 147 (-3.7A) None	1.00A	4hvrA-3eyyA: undetectable	4hvrA-3eyyA: 22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZRD_B_CUB606_0 (TYROSINASE)	3eyy	PUTATIVE IRON UPTAKE REGULATORY PROTEIN (Streptomyces coelicolor)	4 / 5	HIS A 86 HIS A 33 HIS A 90 HIS A 88	ZN A 147 (-3.3A) ZN A 147 (-3.3A) ZN A 147 (-3.3A) ZN A 147 (-3.7A)	1.06A	5zrdB-3eyyA: undetectable	5zrdB-3eyyA: 14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZRD_C_CUC604_0 (TYROSINASE)	3eyy	PUTATIVE IRON UPTAKE REGULATORY PROTEIN (Streptomyces coelicolor)	4 / 4	HIS A 86 HIS A 33 HIS A 90 HIS A 88	ZN A 147 (-3.3A) ZN A 147 (-3.3A) ZN A 147 (-3.3A) ZN A 147 (-3.7A)	1.10A	5zrdC-3eyyA: undetectable	5zrdC-3eyyA: 14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZRD_D_CUD607_0 (TYROSINASE)	3eyy	PUTATIVE IRON UPTAKE REGULATORY PROTEIN (Streptomyces coelicolor)	4 / 4	HIS A 86 HIS A 33 HIS A 90 HIS A 88	ZN A 147 (-3.3A) ZN A 147 (-3.3A) ZN A 147 (-3.3A) ZN A 147 (-3.7A)	1.12A	5zrdD-3eyyA: undetectable	5zrdD-3eyyA: 14.84

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1OE2_A_CUA502_0","DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE","3eyy","PUTATIVE IRON UPTAKE REGULATORY PROTEIN","Streptomyces coelicolor",3,"GLU A 101;HIS A  90;HIS A  88"," ZN A 147 ( 4.0A); ZN A 147 (-3.3A); ZN A 147 (-3.7A)","0.67A","1oe2A-3eyyA:undetectable","1oe2A-3eyyA:19.79"],["2WKO_A_CUA154_0","SUPEROXIDE DISMUTASE [CU-ZN]","3eyy","PUTATIVE IRON UPTAKE REGULATORY PROTEIN","Streptomyces coelicolor",4,"HIS A  86;HIS A  90;HIS A  88;HIS A  33"," ZN A 147 (-3.3A); ZN A 147 (-3.3A); ZN A 147 (-3.7A); ZN A 147 (-3.3A)","1.00A","2wkoA-3eyyA:undetectable","2wkoA-3eyyA:19.75"],["4EM2_A_SALA504_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","3eyy","PUTATIVE IRON UPTAKE REGULATORY PROTEIN","Streptomyces coelicolor",4,"LEU A  23;ILE A  50;THR A  54;THR A  58","None","0.70A","4em2A-3eyyA:6.5","4em2A-3eyyA:22.99"],["4HVR_A_SALA203_1","3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE","3eyy","PUTATIVE IRON UPTAKE REGULATORY PROTEIN","Streptomyces coelicolor",4,"HIS A  86;GLU A 101;HIS A  88;VAL A  99"," ZN A 147 (-3.3A); ZN A 147 ( 4.0A); ZN A 147 (-3.7A);None","1.00A","4hvrA-3eyyA:undetectable","4hvrA-3eyyA:22.75"],["5ZRD_B_CUB606_0","TYROSINASE","3eyy","PUTATIVE IRON UPTAKE REGULATORY PROTEIN","Streptomyces coelicolor",4,"HIS A  86;HIS A  33;HIS A  90;HIS A  88"," ZN A 147 (-3.3A); ZN A 147 (-3.3A); ZN A 147 (-3.3A); ZN A 147 (-3.7A)","1.06A","5zrdB-3eyyA:undetectable","5zrdB-3eyyA:14.84"],["5ZRD_C_CUC604_0","TYROSINASE","3eyy","PUTATIVE IRON UPTAKE REGULATORY PROTEIN","Streptomyces coelicolor",4,"HIS A  86;HIS A  33;HIS A  90;HIS A  88"," ZN A 147 (-3.3A); ZN A 147 (-3.3A); ZN A 147 (-3.3A); ZN A 147 (-3.7A)","1.10A","5zrdC-3eyyA:undetectable","5zrdC-3eyyA:14.84"],["5ZRD_D_CUD607_0","TYROSINASE","3eyy","PUTATIVE IRON UPTAKE REGULATORY PROTEIN","Streptomyces coelicolor",4,"HIS A  86;HIS A  33;HIS A  90;HIS A  88"," ZN A 147 (-3.3A); ZN A 147 (-3.3A); ZN A 147 (-3.3A); ZN A 147 (-3.7A)","1.12A","5zrdD-3eyyA:undetectable","5zrdD-3eyyA:14.84"]]