SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ez0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		5 / 9 LEU A 209
ILE A 206
ARG A 216
GLY A 170
ALA A 176
 None
None
None
None
UNL  A 500 ( 4.1A)
 1.32A 1e7aA-3ez0A:
undetectable		 1e7aA-3ez0A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		5 / 12 ILE A 133
ALA A 135
ILE A 118
LEU A  18
ILE A 130
 UNL  A 500 (-4.7A)
None
None
None
None
 1.07A 1ra3A-3ez0A:
undetectable		 1ra3A-3ez0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		5 / 12 ILE A 133
ALA A 135
ILE A 118
LEU A  18
ILE A 130
 UNL  A 500 (-4.7A)
None
None
None
None
 1.00A 1rd7B-3ez0A:
undetectable		 1rd7B-3ez0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		5 / 12 ALA A  23
GLU A  26
LEU A  27
LEU A  62
MET A  70
 None
UNL  A 500 (-3.5A)
None
None
None
 1.10A 2jfaA-3ez0A:
undetectable		 2jfaA-3ez0A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		4 / 8 GLU A 131
SER A 119
ARG A  66
VAL A 122
 None
 1.32A 3jx1A-3ez0A:
undetectable
3jx1B-3ez0A:
undetectable		 3jx1A-3ez0A:
19.14
3jx1B-3ez0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		4 / 8 GLU A 131
SER A 119
ARG A  66
VAL A 122
 None
 1.34A 3nlyA-3ez0A:
undetectable
3nlyB-3ez0A:
undetectable		 3nlyA-3ez0A:
19.14
3nlyB-3ez0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		4 / 8 GLU A 131
SER A 119
ARG A  66
VAL A 122
 None
 1.32A 3rqlA-3ez0A:
undetectable
3rqlB-3ez0A:
undetectable		 3rqlA-3ez0A:
19.14
3rqlB-3ez0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		4 / 6 HIS A  59
SER A 111
ASP A  36
ASP A 108
 UNL  A 500 (-3.7A)
UNL  A 500 (-3.5A)
None
None
 1.40A 4blvA-3ez0A:
undetectable		 4blvA-3ez0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		4 / 8 GLU A 131
SER A 119
ARG A  66
VAL A 122
 None
 1.35A 4capA-3ez0A:
1.2
4capB-3ez0A:
undetectable		 4capA-3ez0A:
19.14
4capB-3ez0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		4 / 8 GLU A 131
SER A 119
ARG A  66
VAL A 122
 None
 1.37A 4d32A-3ez0A:
undetectable
4d32B-3ez0A:
undetectable		 4d32A-3ez0A:
19.14
4d32B-3ez0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		5 / 12 ILE A 133
ALA A 135
ILE A 118
LEU A  18
ILE A 130
 UNL  A 500 (-4.7A)
None
None
None
None
 1.04A 4kjkA-3ez0A:
undetectable		 4kjkA-3ez0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		5 / 12 SER A 180
LEU A 189
VAL A  15
PHE A 114
LEU A 209
 None
None
None
UNL  A 500 ( 4.0A)
None
 1.46A 4o8fB-3ez0A:
2.2		 4o8fB-3ez0A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		4 / 8 GLU A 131
SER A 119
ARG A  66
VAL A 122
 None
 1.36A 4v3yA-3ez0A:
undetectable
4v3yB-3ez0A:
undetectable		 4v3yA-3ez0A:
19.14
4v3yB-3ez0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		5 / 12 ALA A  23
GLU A  26
LEU A  27
LEU A  62
MET A  70
 None
UNL  A 500 (-3.5A)
None
None
None
 1.19A 4xi3D-3ez0A:
undetectable		 4xi3D-3ez0A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		5 / 12 VAL A 110
ASP A 113
PHE A  33
ARG A 216
LEU A 143
 None
 1.48A 5m54B-3ez0A:
undetectable		 5m54B-3ez0A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		5 / 12 VAL A 179
GLY A 187
GLU A 200
PHE A 185
TYR A 121
 None
 1.17A 5n5dA-3ez0A:
undetectable		 5n5dA-3ez0A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		4 / 8 SER A 119
ARG A  66
VAL A 122
GLU A 131
 None
 1.32A 5uo7A-3ez0A:
undetectable
5uo7B-3ez0A:
undetectable		 5uo7A-3ez0A:
17.58
5uo7B-3ez0A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD
(Arthrobacter
sp.
FB24) 		5 / 12 ILE A 133
ALA A 135
ILE A 118
LEU A  18
ILE A 130
 UNL  A 500 (-4.7A)
None
None
None
None
 0.96A 7dfrA-3ez0A:
undetectable		 7dfrA-3ez0A:
20.98