SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ez1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		5 / 12 GLY A 101
LEU A 139
LEU A 140
LEU A 108
ALA A 107
 None
 0.98A 1gseB-3ez1A:
undetectable		 1gseB-3ez1A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 6 GLU A 187
GLY A 156
SER A 182
PHE A 177
 None
 1.16A 1icuA-3ez1A:
undetectable
1icuB-3ez1A:
undetectable		 1icuA-3ez1A:
20.57
1icuB-3ez1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		5 / 11 ALA A  13
VAL A 359
LEU A 362
ALA A 363
ALA A 366
 None
 1.08A 1jinA-3ez1A:
undetectable		 1jinA-3ez1A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 6 SER A 182
PHE A 177
GLU A 187
GLY A 156
 None
 1.15A 1kqbA-3ez1A:
undetectable
1kqbB-3ez1A:
undetectable		 1kqbA-3ez1A:
20.19
1kqbB-3ez1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 6 SER A 182
PHE A 177
GLU A 187
GLY A 156
 None
 1.14A 1kqbC-3ez1A:
undetectable
1kqbD-3ez1A:
undetectable		 1kqbC-3ez1A:
20.19
1kqbD-3ez1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 8 ILE A 253
LEU A 306
PHE A 295
GLY A  44
 None
 0.93A 1os6A-3ez1A:
undetectable		 1os6A-3ez1A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		3 / 3 THR A 376
PRO A 378
PRO A 131
 None
 0.78A 2d55C-3ez1A:
undetectable		 2d55C-3ez1A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		5 / 11 GLY A 261
SER A 249
GLY A 259
HIS A 292
PHE A 295
 None
PO4  A 423 (-2.7A)
None
None
None
 1.42A 2hmaA-3ez1A:
undetectable		 2hmaA-3ez1A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		3 / 3 GLN A 122
THR A 208
TRP A 272
 None
 0.94A 2rctA-3ez1A:
undetectable		 2rctA-3ez1A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		5 / 12 LEU A 143
ILE A 175
ILE A 127
MET A 152
ILE A 189
 None
 1.11A 2ygnA-3ez1A:
undetectable		 2ygnA-3ez1A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 8 GLU A 288
THR A  47
VAL A  48
LEU A  49
 None
 0.96A 3ax7A-3ez1A:
undetectable		 3ax7A-3ez1A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		5 / 10 TYR A 335
THR A 351
VAL A 355
VAL A 359
LEU A 362
 None
 1.43A 3casA-3ez1A:
undetectable		 3casA-3ez1A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 7 VAL A 355
VAL A 359
LEU A 362
VAL A 406
 None
 0.83A 3hs6B-3ez1A:
undetectable		 3hs6B-3ez1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 8 ILE A 253
LEU A 306
PHE A 295
GLY A  44
 None
 0.74A 3selX-3ez1A:
undetectable		 3selX-3ez1A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 6 ILE A 253
LEU A 306
PHE A 295
GLY A  44
 None
 0.96A 3sj1X-3ez1A:
undetectable		 3sj1X-3ez1A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 7 GLU A 288
THR A  47
VAL A  48
LEU A  49
 None
 0.92A 3uniA-3ez1A:
undetectable		 3uniA-3ez1A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		5 / 12 LEU A 340
GLY A 344
GLY A 186
ILE A 347
LEU A 220
 None
 0.98A 4gc9A-3ez1A:
undetectable		 4gc9A-3ez1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 7 ILE A 253
LEU A 306
PHE A 295
GLY A  44
 None
 0.94A 4hajA-3ez1A:
undetectable		 4hajA-3ez1A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 7 ILE A 253
LEU A 306
PHE A 295
GLY A  44
 None
 0.96A 4hbfA-3ez1A:
undetectable		 4hbfA-3ez1A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 7 ILE A 253
LEU A 306
PHE A 295
GLY A  44
 None
 0.90A 4hc3A-3ez1A:
undetectable		 4hc3A-3ez1A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		5 / 12 MET A 404
VAL A 407
ILE A 347
LEU A 390
ALA A 336
 None
 1.26A 4m11C-3ez1A:
undetectable		 4m11C-3ez1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		5 / 12 MET A 404
VAL A 407
ILE A 347
LEU A 390
ALA A 336
 None
 1.22A 4m11D-3ez1A:
undetectable		 4m11D-3ez1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 6 LEU A 273
PHE A 210
THR A 208
VAL A 112
 None
 1.03A 4udaA-3ez1A:
undetectable		 4udaA-3ez1A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 5 GLU A 323
THR A 393
HIS A 218
LEU A 220
 None
 1.17A 5axaA-3ez1A:
3.7		 5axaA-3ez1A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 5 GLU A 323
THR A 393
HIS A 218
LEU A 220
 None
 1.19A 5axaC-3ez1A:
3.8		 5axaC-3ez1A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 4 LEU A 260
GLY A 261
SER A 249
SER A 251
 None
None
PO4  A 423 (-2.7A)
PO4  A 423 (-2.7A)
 1.26A 5uunB-3ez1A:
undetectable		 5uunB-3ez1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3ez1 AMINOTRANSFERASE
MOCR FAMILY
(Deinococcus
geothermalis) 		4 / 8 VAL A 359
ILE A 411
THR A 415
TYR A 418
 None
 0.98A 6cduG-3ez1A:
undetectable
6cduH-3ez1A:
undetectable		 6cduG-3ez1A:
22.97
6cduH-3ez1A:
22.97