SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ez4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
pseudomallei) 		4 / 5 ASP A  43
GLU A 112
THR A  87
LEU A  83
 None
 1.23A 1u18B-3ez4A:
undetectable		 1u18B-3ez4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
pseudomallei) 		5 / 12 GLN A 235
ASP A  37
VAL A  36
HIS A   0
ALA A 240
 None
 1.36A 2g70A-3ez4A:
undetectable		 2g70A-3ez4A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
pseudomallei) 		5 / 12 GLN A 235
ASP A  37
VAL A  36
HIS A   0
ALA A 240
 None
 1.35A 2g70B-3ez4A:
undetectable		 2g70B-3ez4A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
pseudomallei) 		5 / 12 THR A  87
SER A  97
THR A  55
ALA A  81
VAL A 129
 None
 1.07A 2nniA-3ez4A:
undetectable		 2nniA-3ez4A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
pseudomallei) 		4 / 8 LEU A  20
VAL A 219
GLY A 218
MET A 232
 None
 1.12A 2qd5A-3ez4A:
undetectable		 2qd5A-3ez4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
pseudomallei) 		4 / 5 ASP A  61
THR A  59
LEU A  60
LYS A 100
 None
 1.49A 4a3pA-3ez4A:
undetectable		 4a3pA-3ez4A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
pseudomallei) 		5 / 12 THR A  21
THR A  55
GLU A 112
ILE A  63
TYR A  23
 None
 1.27A 4s0vA-3ez4A:
3.2		 4s0vA-3ez4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
pseudomallei) 		5 / 12 THR A  21
THR A  55
VAL A  58
GLU A 112
TYR A  23
 None
 1.44A 4s0vA-3ez4A:
3.2		 4s0vA-3ez4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
pseudomallei) 		5 / 12 VAL A 210
THR A  55
VAL A  58
GLU A 112
TYR A  23
 None
 1.40A 4s0vA-3ez4A:
3.2		 4s0vA-3ez4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
pseudomallei) 		5 / 10 ALA A  94
ALA A  98
VAL A 129
LEU A 117
VAL A 131
 None
 1.37A 5eb5B-3ez4A:
undetectable		 5eb5B-3ez4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
pseudomallei) 		5 / 12 MET A  10
ILE A 198
LEU A   7
LEU A  78
VAL A   2
 None
 1.22A 5im2A-3ez4A:
undetectable		 5im2A-3ez4A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
pseudomallei) 		3 / 3 LYS A 110
VAL A  80
ASP A  82
 None
 0.62A 6fgdA-3ez4A:
undetectable		 6fgdA-3ez4A:
21.11