SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ez6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		4 / 7 ALA A 267
PHE A 112
VAL A 110
VAL A 250
 None
 0.75A 1epbA-3ez6A:
undetectable		 1epbA-3ez6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		4 / 8 ALA A 267
PHE A 112
VAL A 110
VAL A 250
 None
 0.85A 1epbB-3ez6A:
undetectable		 1epbB-3ez6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		4 / 8 LYS A 100
SER A  85
ASP A  72
GLU A  94
 None
 0.90A 1knyA-3ez6A:
undetectable
1knyB-3ez6A:
undetectable		 1knyA-3ez6A:
19.90
1knyB-3ez6A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		3 / 3 ASP A 390
HIS A 136
ASP A 383
 None
 0.73A 1nw5A-3ez6A:
undetectable		 1nw5A-3ez6A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		4 / 7 VAL A 197
VAL A 148
TYR A 109
ARG A 378
 None
 0.86A 1t46A-3ez6A:
undetectable		 1t46A-3ez6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		4 / 7 VAL A 359
SER A 128
LEU A 346
PHE A 384
 None
 1.00A 2f78A-3ez6A:
undetectable		 2f78A-3ez6A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		4 / 7 VAL A 359
SER A 128
LEU A 346
PHE A 384
 None
 0.90A 2f78B-3ez6A:
undetectable		 2f78B-3ez6A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 12 ILE A 149
VAL A 110
ALA A 108
TYR A 245
LEU A 188
 None
 1.09A 2japA-3ez6A:
3.0		 2japA-3ez6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 12 ILE A 149
VAL A 110
ALA A 108
TYR A 245
LEU A 188
 None
 1.11A 2japB-3ez6A:
3.1		 2japB-3ez6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 12 ILE A 149
VAL A 110
ALA A 108
TYR A 245
LEU A 188
 None
 1.10A 2japC-3ez6A:
2.9		 2japC-3ez6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 12 ILE A 149
VAL A 110
ALA A 108
TYR A 245
LEU A 188
 None
 1.10A 2japD-3ez6A:
2.9		 2japD-3ez6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		4 / 6 LEU A 241
TYR A 245
ILE A 149
ILE A 192
 None
 0.93A 2q8hA-3ez6A:
undetectable		 2q8hA-3ez6A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 12 GLY A 348
SER A 355
VAL A 124
ALA A 362
SER A 361
 None
None
ADP  A 501 (-3.7A)
None
None
 1.09A 3d91B-3ez6A:
undetectable		 3d91B-3ez6A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 12 THR A 173
ALA A 177
LEU A 233
LEU A 241
LEU A 151
 None
 1.12A 3hm1A-3ez6A:
undetectable		 3hm1A-3ez6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQZ_A_LQZA586_1
(SERUM ALBUMIN)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		4 / 6 ARG A 145
ARG A 102
ASP A 103
ARG A 396
 None
 1.35A 3jqzA-3ez6A:
0.6		 3jqzA-3ez6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ACTA908_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		4 / 4 MET A 178
SER A 174
LEU A 233
VAL A 237
 None
 1.45A 3vlnA-3ez6A:
0.0		 3vlnA-3ez6A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 6 PHE A 112
ALA A 263
GLY A 253
PRO A 254
LEU A 260
 None
None
MG  A 399 ( 4.7A)
None
None
 1.12A 4dubB-3ez6A:
undetectable		 4dubB-3ez6A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 11 SER A 125
ILE A 113
LEU A 291
GLY A 312
PHE A 313
 None
 1.38A 4fogA-3ez6A:
undetectable		 4fogA-3ez6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 11 SER A 125
ILE A 113
LEU A 291
GLY A 312
PHE A 313
 None
 1.29A 4fogC-3ez6A:
undetectable		 4fogC-3ez6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		3 / 3 LEU A 241
ASP A 244
TYR A 245
 None
 0.64A 4qc6B-3ez6A:
undetectable		 4qc6B-3ez6A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 12 TYR A 101
LEU A 129
ALA A 385
PHE A 384
ILE A 392
 None
 1.40A 5ljbA-3ez6A:
undetectable		 5ljbA-3ez6A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 12 MET A 133
ALA A 387
LEU A 129
ILE A 111
TYR A 105
 None
 1.37A 5vlmA-3ez6A:
undetectable		 5vlmA-3ez6A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 11 ASP A 357
SER A 361
SER A 174
ALA A 177
VAL A 148
 None
 1.43A 6hu9A-3ez6A:
undetectable
6hu9E-3ez6A:
undetectable
6hu9I-3ez6A:
undetectable		 6hu9A-3ez6A:
24.30
6hu9E-3ez6A:
19.70
6hu9I-3ez6A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3ez6 PLASMID PARTITION
PROTEIN A
(Escherichia
coli) 		5 / 10 ASP A 357
SER A 361
SER A 174
ALA A 177
VAL A 148
 None
 1.40A 6hu9L-3ez6A:
undetectable
6hu9P-3ez6A:
undetectable
6hu9T-3ez6A:
undetectable		 6hu9L-3ez6A:
24.30
6hu9P-3ez6A:
19.70
6hu9T-3ez6A:
11.20