SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ez9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 3ez9 PARA
(Salmonella
enterica) 		4 / 4 HIS A 106
LEU A 140
LEU A 134
LEU A 272
 None
 0.93A 1a4lD-3ez9A:
undetectable		 1a4lD-3ez9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 3ez9 PARA
(Salmonella
enterica) 		4 / 7 ARG A 135
VAL A 136
ASP A 144
LYS A 101
 None
 1.35A 1hwiC-3ez9A:
undetectable		 1hwiC-3ez9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 3ez9 PARA
(Salmonella
enterica) 		4 / 7 ARG A 135
VAL A 136
ASP A 144
LYS A 101
 None
 1.35A 1hwiD-3ez9A:
undetectable		 1hwiD-3ez9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3ez9 PARA
(Salmonella
enterica) 		4 / 7 LEU A 261
TYR A 231
LEU A 296
GLN A 298
 None
 1.01A 1kt3A-3ez9A:
undetectable		 1kt3A-3ez9A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ez9 PARA
(Salmonella
enterica) 		5 / 11 SER A 316
ILE A 393
VAL A 389
ALA A 388
PHE A 385
 None
 1.24A 1uduA-3ez9A:
undetectable		 1uduA-3ez9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3ez9 PARA
(Salmonella
enterica) 		4 / 6 VAL A  47
LEU A  53
PHE A  72
MET A  65
 None
 0.90A 1wrlB-3ez9A:
undetectable		 1wrlB-3ez9A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 3ez9 PARA
(Salmonella
enterica) 		5 / 11 GLU A 173
VAL A 192
ILE A 193
LEU A 188
ILE A 251
 None
 1.16A 2dg9A-3ez9A:
undetectable		 2dg9A-3ez9A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 3ez9 PARA
(Salmonella
enterica) 		4 / 5 TYR A  38
ALA A 382
ALA A 131
MET A 160
 None
 1.06A 3d91A-3ez9A:
undetectable		 3d91A-3ez9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQZ_A_LQZA586_1
(SERUM ALBUMIN)		 3ez9 PARA
(Salmonella
enterica) 		4 / 6 ARG A 146
ARG A 103
ASP A 104
ARG A 397
 None
 1.32A 3jqzA-3ez9A:
undetectable		 3jqzA-3ez9A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3ez9 PARA
(Salmonella
enterica) 		5 / 11 ILE A  87
GLU A  37
THR A  36
VAL A 198
PRO A 199
 None
 1.04A 3tmzA-3ez9A:
undetectable		 3tmzA-3ez9A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 3ez9 PARA
(Salmonella
enterica) 		5 / 10 ALA A 310
ILE A 393
GLY A 313
ILE A 339
VAL A 396
 None
 1.03A 4j5jB-3ez9A:
undetectable		 4j5jB-3ez9A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3ez9 PARA
(Salmonella
enterica) 		4 / 6 ILE A 147
VAL A 136
THR A 386
ARG A 397
 None
 1.16A 4xe5A-3ez9A:
undetectable		 4xe5A-3ez9A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3ez9 PARA
(Salmonella
enterica) 		5 / 9 LEU A 152
ILE A 204
ARG A 241
ILE A 233
GLU A 232
 None
None
None
None
MG  A 402 (-3.1A)
 1.50A 5igzA-3ez9A:
undetectable		 5igzA-3ez9A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3ez9 PARA
(Salmonella
enterica) 		3 / 3 GLN A 177
THR A 174
ASP A 210
 None
 0.70A 5k9dA-3ez9A:
undetectable		 5k9dA-3ez9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3ez9 PARA
(Salmonella
enterica) 		3 / 3 PHE A 260
ASP A 153
LEU A 271
 None
 0.60A 5uhbC-3ez9A:
undetectable		 5uhbC-3ez9A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3ez9 PARA
(Salmonella
enterica) 		3 / 3 PHE A 260
ASP A 153
LEU A 271
 None
 0.71A 5uhcC-3ez9A:
undetectable		 5uhcC-3ez9A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 3ez9 PARA
(Salmonella
enterica) 		5 / 12 PHE A 314
VAL A 389
VAL A 114
LEU A 130
THR A 129
 None
 1.03A 6bccA-3ez9A:
undetectable		 6bccA-3ez9A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 3ez9 PARA
(Salmonella
enterica) 		3 / 3 TYR A 102
HIS A 143
PHE A 390
 None
 0.96A 6esmA-3ez9A:
undetectable		 6esmA-3ez9A:
11.17