SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I
(Escherichia
coli) 		4 / 8 LEU A  85
ILE A  89
LEU A 137
ILE A 133
 None
 0.78A 2azxA-3ezaA:
undetectable		 2azxA-3ezaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I
(Escherichia
coli) 		5 / 12 LEU A 142
GLY A 143
LEU A 144
ILE A  24
ASP A 132
 None
 1.08A 3gwwA-3ezaA:
undetectable		 3gwwA-3ezaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I
(Escherichia
coli) 		5 / 12 GLY A   4
GLY A 204
VAL A 223
ASP A 221
PRO A 200
 None
 1.09A 3m6vA-3ezaA:
undetectable		 3m6vA-3ezaA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I
(Escherichia
coli) 		5 / 12 GLY A   4
GLY A 204
VAL A 223
ASP A 221
PRO A 200
 None
 1.07A 3m6vB-3ezaA:
undetectable		 3m6vB-3ezaA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I
(Escherichia
coli) 		5 / 12 GLY A   4
GLY A 204
VAL A 223
ASP A 221
PRO A 200
 None
 1.07A 3m6wA-3ezaA:
undetectable		 3m6wA-3ezaA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I
(Escherichia
coli) 		5 / 12 VAL A 203
ALA A 183
GLY A 184
ALA A 128
HIS A 189
 None
 1.20A 3qxyA-3ezaA:
undetectable		 3qxyA-3ezaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I
(Escherichia
coli) 		4 / 7 VAL A 227
ILE A 180
ILE A 157
ALA A  16
 None
 0.80A 4lv9A-3ezaA:
undetectable		 4lv9A-3ezaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I
(Escherichia
coli) 		4 / 8 LEU A 197
ILE A 192
VAL A 203
THR A 181
 None
 0.92A 4ma7A-3ezaA:
undetectable		 4ma7A-3ezaA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I
(Escherichia
coli) 		5 / 12 SER A 166
LEU A 142
ASP A 132
GLY A 134
ILE A  57
 None
 1.14A 6dwnA-3ezaA:
undetectable		 6dwnA-3ezaA:
17.01