SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ezj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
NANOBODY NBGSPD_7
(Escherichia
coli;
Lama
glama) 		4 / 5 VAL A 135
VAL A 134
THR A 156
ARG B 107
 None
 1.18A 3bjwA-3ezjA:
1.8		 3bjwA-3ezjA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		4 / 7 LEU A  60
TYR A  65
LYS A  76
ILE A  30
 None
 1.15A 3ik3B-3ezjA:
undetectable		 3ik3B-3ezjA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		5 / 12 ALA A   7
GLN A  54
LEU A  60
VAL A  39
THR A  43
 None
 1.02A 3ix9B-3ezjA:
undetectable		 3ix9B-3ezjA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		5 / 11 ILE A 126
ALA A 129
GLY A 130
GLY A 100
ASN A 133
 None
PO4  A 238 (-4.1A)
None
None
None
 0.82A 4e47A-3ezjA:
undetectable		 4e47A-3ezjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		5 / 11 ILE A 126
ALA A 129
GLY A 130
GLY A 100
ASN A 133
 None
PO4  A 238 (-4.1A)
None
None
None
 0.83A 4e47B-3ezjA:
undetectable		 4e47B-3ezjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		5 / 11 ILE A 126
ALA A 129
GLY A 130
GLY A 100
ASN A 133
 None
PO4  A 238 (-4.1A)
None
None
None
 0.82A 4e47C-3ezjA:
undetectable		 4e47C-3ezjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		5 / 11 ILE A 126
ALA A 129
GLY A 130
GLY A 100
ASN A 133
 None
PO4  A 238 (-4.1A)
None
None
None
 0.83A 4jdsA-3ezjA:
undetectable		 4jdsA-3ezjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		5 / 11 ILE A 126
ALA A 129
GLY A 130
GLY A 100
ASN A 133
 None
PO4  A 238 (-4.1A)
None
None
None
 0.82A 4jdsB-3ezjA:
undetectable		 4jdsB-3ezjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		5 / 11 ILE A 126
ALA A 129
GLY A 130
GLY A 100
ASN A 133
 None
PO4  A 238 (-4.1A)
None
None
None
 0.84A 4jdsC-3ezjA:
undetectable		 4jdsC-3ezjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		5 / 12 ILE A 126
ALA A 129
GLY A 130
GLY A 100
ASN A 133
 None
PO4  A 238 (-4.1A)
None
None
None
 0.83A 4jlgA-3ezjA:
undetectable		 4jlgA-3ezjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		4 / 7 ALA A   7
THR A   6
MET A 103
THR A 105
 None
 0.89A 4qw0K-3ezjA:
undetectable		 4qw0K-3ezjA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		4 / 7 ALA A   7
THR A   6
MET A 103
THR A 105
 None
 0.90A 4qw0Y-3ezjA:
undetectable		 4qw0Y-3ezjA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		5 / 11 ILE A 126
ALA A 129
GLY A 130
GLY A 100
ASN A 133
 None
PO4  A 238 (-4.1A)
None
None
None
 0.84A 5ayfA-3ezjA:
undetectable		 5ayfA-3ezjA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3ezj NANOBODY NBGSPD_7
(Lama
glama) 		4 / 7 ALA B  91
THR B  90
VAL B 116
GLU B  88
 None
 0.74A 5ecmD-3ezjB:
undetectable		 5ecmD-3ezjB:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		3 / 3 ASN A 133
ASP A 101
GLY A 100
 None
 0.63A 5fctB-3ezjA:
undetectable		 5fctB-3ezjA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		3 / 3 LEU A  57
GLN A  54
LYS A  27
 None
 0.99A 6exiB-3ezjA:
undetectable		 6exiB-3ezjA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3ezj GENERAL SECRETION
PATHWAY PROTEIN GSPD
(Escherichia
coli) 		5 / 9 ILE A 126
ALA A 129
GLY A 130
GLY A 100
ASN A 133
 None
PO4  A 238 (-4.1A)
None
None
None
 0.91A 6nm4B-3ezjA:
undetectable		 6nm4B-3ezjA:
18.85