SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ezl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3ezl ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		4 / 8 GLY A  82
VAL A  77
GLU A  80
ILE A  84
 None
 0.77A 1pk7B-3ezlA:
2.9		 1pk7B-3ezlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3ezl ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 12 PHE A  55
ASN A  90
ILE A 140
GLY A 220
ILE A  21
 None
 1.19A 2ogyA-3ezlA:
undetectable		 2ogyA-3ezlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3ezl ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 11 THR A 190
ILE A 188
GLY A 189
GLY A  16
PRO A 185
 None
 1.43A 2y7kA-3ezlA:
undetectable		 2y7kA-3ezlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3ezl ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 10 THR A 190
ILE A 188
GLY A 189
GLY A  16
PRO A 185
 None
 1.46A 2y7pA-3ezlA:
undetectable		 2y7pA-3ezlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3ezl ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 12 TYR A 155
ILE A 188
GLY A 186
ILE A 208
GLY A 214
 None
 1.01A 3bwcA-3ezlA:
4.4		 3bwcA-3ezlA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3ezl ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 12 TYR A 155
ILE A 188
GLY A 186
ILE A 208
GLY A 214
 None
 1.03A 3bwcB-3ezlA:
4.9		 3bwcB-3ezlA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ezl ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		3 / 3 GLY A 232
SER A 231
TRP A 225
 None
 0.78A 4e7cD-3ezlA:
undetectable		 4e7cD-3ezlA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3ezl ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 226
GLU A 172
GLY A 236
PHE A 165
LEU A 118
 None
 1.10A 4hytA-3ezlA:
4.3		 4hytA-3ezlA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3ezl ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 226
GLU A 172
GLY A 236
PHE A 165
LEU A 118
 None
 1.13A 4hytC-3ezlA:
undetectable		 4hytC-3ezlA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3ezl ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 10 GLY A 220
ALA A 227
VAL A 223
ASP A 217
ILE A  21
 None
 1.19A 5i3cB-3ezlA:
undetectable		 5i3cB-3ezlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3ezl ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 12 VAL A  81
ILE A  84
THR A  11
GLY A  12
GLY A  13
 None
None
P4C  A 249 ( 4.7A)
P4C  A 249 (-3.7A)
None
 0.92A 5koxA-3ezlA:
4.4		 5koxA-3ezlA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3ezl ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A  87
GLY A  12
GLY A  35
ILE A  21
ILE A 140
 None
P4C  A 249 (-3.7A)
P4C  A 249 (-3.2A)
None
None
 1.00A 6ecxA-3ezlA:
4.7		 6ecxA-3ezlA:
21.65