SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ezo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		4 / 8 ILE A 166
GLU A 146
ALA A 147
VAL A 153
 None
 0.72A 1a29A-3ezoA:
undetectable		 1a29A-3ezoA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		4 / 5 PHE A 158
ARG A 141
ILE A 229
PRO A 251
 None
 1.49A 1oniG-3ezoA:
undetectable
1oniH-3ezoA:
undetectable		 1oniG-3ezoA:
22.95
1oniH-3ezoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		5 / 12 ASN A 157
SER A 206
GLN A 247
HIS A  88
VAL A 255
 None
 1.42A 1qu3A-3ezoA:
undetectable		 1qu3A-3ezoA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		5 / 12 GLY A 168
GLY A 128
ILE A 166
ALA A 130
SER A 199
 None
 1.09A 1ri4A-3ezoA:
undetectable		 1ri4A-3ezoA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		4 / 8 LEU A 213
LEU A 110
ASP A 106
ASP A 217
 None
 0.90A 2j2pA-3ezoA:
undetectable
2j2pB-3ezoA:
undetectable		 2j2pA-3ezoA:
18.54
2j2pB-3ezoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		5 / 12 PHE A   6
TYR A  71
PRO A 221
ALA A 220
ALA A   3
 None
 1.29A 2x2nB-3ezoA:
undetectable		 2x2nB-3ezoA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		5 / 12 PRO A 190
GLY A 168
GLY A 172
GLY A 127
GLY A 128
 None
 1.03A 3axzA-3ezoA:
undetectable		 3axzA-3ezoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		5 / 12 GLU A 154
GLY A 168
ASN A 157
GLY A 250
SER A 200
 None
 0.93A 3k13B-3ezoA:
undetectable		 3k13B-3ezoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A 105
PRO A  61
PHE A 104
 None
 0.95A 3thrC-3ezoA:
undetectable		 3thrC-3ezoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		3 / 3 GLU A 271
GLY A 275
SER A 293
 None
 0.66A 4b53B-3ezoA:
undetectable		 4b53B-3ezoA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		5 / 12 ARG A 112
ASN A  54
LEU A  53
ILE A  45
GLN A  12
 None
 1.41A 4kukA-3ezoA:
undetectable		 4kukA-3ezoA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		4 / 4 HIS A 260
ALA A 232
VAL A 231
GLU A  92
 None
 1.48A 4n6pA-3ezoA:
0.0		 4n6pA-3ezoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		4 / 8 LEU A 110
VAL A 218
VAL A  97
LEU A 213
 None
 0.97A 4puoC-3ezoA:
undetectable		 4puoC-3ezoA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		4 / 5 GLN A   9
LEU A  90
SER A  89
ASP A 207
 None
 1.25A 4qtuD-3ezoA:
undetectable		 4qtuD-3ezoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		5 / 11 GLY A 273
PHE A 295
ALA A 298
ASP A 301
PHE A   4
 None
 1.29A 4wnuC-3ezoA:
undetectable		 4wnuC-3ezoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		4 / 8 ILE A 261
VAL A 269
THR A 282
ILE A 285
 None
 0.91A 5mzrE-3ezoA:
undetectable		 5mzrE-3ezoA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Burkholderia
pseudomallei) 		4 / 7 ILE A  41
LEU A  44
LEU A  53
PRO A  61
 None
 0.98A 5u4sA-3ezoA:
undetectable		 5u4sA-3ezoA:
25.62