SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ezq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ezq PROTEIN FADD
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 6
(Homo
sapiens) 		5 / 11 TYR A 232
ILE A 236
VAL B 103
ALA B 100
LEU B 165
 None
 1.23A 1uduA-3ezqA:
undetectable		 1uduA-3ezqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3ezq PROTEIN FADD
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 6
(Homo
sapiens) 		5 / 11 VAL B 180
GLU B  95
ALA B  99
THR A 235
VAL A 239
 None
 0.95A 4e0fA-3ezqB:
undetectable		 4e0fA-3ezqB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ezq PROTEIN FADD
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 6
(Homo
sapiens) 		4 / 7 VAL B 158
VAL B 162
LEU B 165
ASN A 302
 None
 0.86A 4e1gB-3ezqB:
undetectable		 4e1gB-3ezqB:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3ezq PROTEIN FADD
(Homo
sapiens) 		5 / 12 VAL B 180
ALA B 174
VAL B 103
LEU B 165
GLY B 163
 None
 0.98A 5igtA-3ezqB:
undetectable		 5igtA-3ezqB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3ezq PROTEIN FADD
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 6
(Homo
sapiens) 		4 / 6 GLY B  93
LEU A 336
ARG B 184
VAL B 158
 None
 0.96A 5x80A-3ezqB:
undetectable
5x80B-3ezqB:
undetectable		 5x80A-3ezqB:
20.13
5x80B-3ezqB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3ezq PROTEIN FADD
(Homo
sapiens) 		3 / 3 VAL B 158
ALA B 100
GLN B 181
 None
 0.64A 6gb9A-3ezqB:
undetectable		 6gb9A-3ezqB:
13.70