SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ezs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori)
4 / 6 LEU A 170
TRP A 178
ASN A 191
LEU A 189
EDO  A 377 (-4.1A)
None
None
None
1.18A 1ru9H-3ezsA:
undetectable
1ru9L-3ezsA:
undetectable
1ru9H-3ezsA:
17.62
1ru9L-3ezsA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori)
4 / 5 LEU A 170
TRP A 178
ASN A 191
LEU A 189
EDO  A 377 (-4.1A)
None
None
None
1.09A 1ruaH-3ezsA:
0.0
1ruaL-3ezsA:
0.0
1ruaH-3ezsA:
17.62
1ruaL-3ezsA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori)
4 / 6 LEU A 170
TRP A 178
ASN A 191
LEU A 189
EDO  A 377 (-4.1A)
None
None
None
1.12A 1rukH-3ezsA:
undetectable
1rukL-3ezsA:
undetectable
1rukH-3ezsA:
17.62
1rukL-3ezsA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori)
4 / 5 LEU A 170
TRP A 178
ASN A 191
LEU A 189
EDO  A 377 (-4.1A)
None
None
None
1.17A 1rulH-3ezsA:
0.0
1rulL-3ezsA:
0.0
1rulH-3ezsA:
17.62
1rulL-3ezsA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori)
4 / 7 ALA A 123
TYR A 120
ILE A 190
ASP A 192
None
None
None
EDO  A 379 (-3.2A)
0.91A 1upfB-3ezsA:
3.3
1upfB-3ezsA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori)
4 / 7 LEU A 364
PHE A 299
LEU A  27
SER A 308
None
1.06A 1wrlE-3ezsA:
undetectable
1wrlF-3ezsA:
undetectable
1wrlE-3ezsA:
16.55
1wrlF-3ezsA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori)
5 / 12 LEU A 325
ASN A 328
GLY A 330
LEU A  14
ILE A  18
None
1.30A 3h52A-3ezsA:
undetectable
3h52A-3ezsA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori)
4 / 6 ILE A 127
PHE A  95
ALA A 123
ASN A  96
None
1.05A 3pgyA-3ezsA:
22.7
3pgyB-3ezsA:
22.9
3pgyA-3ezsA:
21.81
3pgyB-3ezsA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori)
4 / 7 ILE A 190
LEU A 156
ALA A 123
ALA A 124
None
0.83A 3r9tB-3ezsA:
undetectable
3r9tB-3ezsA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori)
5 / 12 PHE A  70
PHE A 219
PHE A 241
ALA A 243
HIS A 226
None
1.40A 3u9fG-3ezsA:
1.3
3u9fH-3ezsA:
1.2
3u9fG-3ezsA:
20.63
3u9fH-3ezsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori)
5 / 10 VAL A  93
ILE A 225
LEU A  84
TYR A 252
ARG A 256
None
1.34A 5fxfB-3ezsA:
0.0
5fxfB-3ezsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori)
3 / 3 LEU A 259
TYR A 252
SER A  99
None
0.84A 5iktA-3ezsA:
undetectable
5iktA-3ezsA:
20.11