SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ezx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 8 ALA A 209
GLU A  92
ALA A  96
THR A  98
 None
 0.92A 1ie4B-3ezxA:
undetectable
1ie4D-3ezxA:
undetectable		 1ie4B-3ezxA:
21.00
1ie4D-3ezxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		5 / 11 VAL A 148
ILE A  97
LEU A 150
LEU A 175
LEU A 170
 None
 1.23A 2a15A-3ezxA:
undetectable		 2a15A-3ezxA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		3 / 3 VAL A 137
GLU A 134
GLU A 138
 None
 0.78A 2nv4A-3ezxA:
undetectable		 2nv4A-3ezxA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 7 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 1.18A 2zxwN-3ezxA:
2.4
2zxwW-3ezxA:
undetectable		 2zxwN-3ezxA:
18.16
2zxwW-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 7 GLY A 162
ALA A 154
VAL A 188
ILE A 196
 None
 0.72A 3a2qA-3ezxA:
undetectable		 3a2qA-3ezxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 7 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 1.02A 3ag2N-3ezxA:
undetectable
3ag2W-3ezxA:
undetectable		 3ag2N-3ezxA:
18.16
3ag2W-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		5 / 12 GLU A 203
GLY A 184
ALA A 202
ALA A 154
VAL A 188
 None
HCB  A   1 (-3.6A)
HCB  A   1 ( 3.7A)
None
None
 1.16A 3nvkF-3ezxA:
2.6
3nvkJ-3ezxA:
3.0		 3nvkF-3ezxA:
21.60
3nvkJ-3ezxA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 6 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 0.83A 3wg7A-3ezxA:
undetectable
3wg7J-3ezxA:
undetectable		 3wg7A-3ezxA:
18.16
3wg7J-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		5 / 11 VAL A 148
ALA A  96
PHE A  99
LEU A 170
VAL A 179
 None
 1.08A 4eilA-3ezxA:
2.1		 4eilA-3ezxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		5 / 10 VAL A 148
ALA A  96
PHE A  99
LEU A 170
VAL A 179
 None
 1.12A 4eilB-3ezxA:
undetectable		 4eilB-3ezxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		5 / 11 VAL A 148
ALA A  96
PHE A  99
LEU A 170
VAL A 179
 None
 1.06A 4eilC-3ezxA:
2.8		 4eilC-3ezxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		5 / 11 VAL A 148
ALA A  96
PHE A  99
LEU A 170
VAL A 179
 None
 1.08A 4eilE-3ezxA:
undetectable		 4eilE-3ezxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		5 / 12 VAL A 148
ALA A  96
PHE A  99
LEU A 170
VAL A 179
 None
 1.19A 4kyaB-3ezxA:
undetectable		 4kyaB-3ezxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		5 / 12 VAL A 148
ALA A  96
PHE A  99
LEU A 170
VAL A 179
 None
 1.18A 4kyaD-3ezxA:
undetectable		 4kyaD-3ezxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		5 / 12 VAL A 148
ALA A  96
PHE A  99
LEU A 170
VAL A 179
 None
 1.18A 4kyaF-3ezxA:
undetectable		 4kyaF-3ezxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		5 / 11 LEU A 213
PHE A 122
ALA A 209
THR A  98
ILE A  97
 None
 1.25A 4uuuB-3ezxA:
undetectable		 4uuuB-3ezxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 8 LEU A  44
ASN A  74
ALA A  75
VAL A  78
 None
 0.83A 4zbqA-3ezxA:
2.2		 4zbqA-3ezxA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 7 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 0.88A 5b1aA-3ezxA:
undetectable
5b1aJ-3ezxA:
undetectable		 5b1aA-3ezxA:
18.16
5b1aJ-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 6 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 0.91A 5b1aN-3ezxA:
undetectable
5b1aW-3ezxA:
undetectable		 5b1aN-3ezxA:
18.16
5b1aW-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 7 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 0.87A 5b3sA-3ezxA:
2.2
5b3sJ-3ezxA:
undetectable		 5b3sA-3ezxA:
18.16
5b3sJ-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 8 ALA A 205
VAL A 113
THR A 201
GLY A 109
 HCB  A   1 (-4.8A)
None
None
HCB  A   1 ( 3.7A)
 1.01A 5v0vA-3ezxA:
2.6		 5v0vA-3ezxA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 8 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 0.83A 5zcoA-3ezxA:
2.2
5zcoJ-3ezxA:
undetectable		 5zcoA-3ezxA:
18.16
5zcoJ-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 7 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 0.87A 5zcpA-3ezxA:
undetectable
5zcpJ-3ezxA:
undetectable		 5zcpA-3ezxA:
18.16
5zcpJ-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 7 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 0.90A 5zcqA-3ezxA:
undetectable
5zcqJ-3ezxA:
undetectable		 5zcqA-3ezxA:
18.16
5zcqJ-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1
(Methanosarcina
barkeri) 		4 / 6 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 0.76A 6nmfN-3ezxA:
undetectable
6nmfW-3ezxA:
undetectable		 6nmfN-3ezxA:
18.16
6nmfW-3ezxA:
14.35