SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ezy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 ILE A 167
PHE A 176
LEU A 321
VAL A 208
 None
 0.90A 1fslA-3ezyA:
undetectable		 1fslA-3ezyA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 SER A   0
LEU A   1
ILE A 291
LYS A 292
 None
 0.87A 1sbrA-3ezyA:
undetectable		 1sbrA-3ezyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		4 / 4 VAL A 114
LEU A  57
ILE A   6
LEU A  67
 None
 1.01A 2byoA-3ezyA:
undetectable		 2byoA-3ezyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 HIS A 144
PHE A 242
GLY A 246
LYS A 245
 None
 1.47A 2i30A-3ezyA:
undetectable		 2i30A-3ezyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 GLY A 206
ALA A 205
PRO A 155
ILE A 161
 None
 0.57A 3el0A-3ezyA:
undetectable		 3el0A-3ezyA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 ARG A 122
PRO A  94
PHE A 120
 None
 1.02A 3thrC-3ezyA:
undetectable		 3thrC-3ezyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 TYR A 279
ASP A 152
ASP A 236
 None
 0.70A 4a6eA-3ezyA:
3.8		 4a6eA-3ezyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 ARG A 147
ASP A 226
ARG A 238
 None
 0.95A 4mx0A-3ezyA:
undetectable		 4mx0A-3ezyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 GLU A  92
LEU A 116
GLY A 307
PHE A 120
ARG A 122
 None
 1.27A 4retC-3ezyA:
undetectable		 4retC-3ezyA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 ASN A 127
TYR A 279
TYR A 283
LEU A 284
 None
 0.97A 4yv5A-3ezyA:
undetectable		 4yv5A-3ezyA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 ASN A 127
TYR A 279
TYR A 283
LEU A 284
 None
 1.00A 4yv5B-3ezyA:
undetectable		 4yv5B-3ezyA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 ASN A  98
ALA A 100
ARG A 104
 None
 0.79A 5cvtB-3ezyA:
6.0		 5cvtB-3ezyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 THR A 289
ALA A 301
ASN A 293
 None
 0.63A 5ersA-3ezyA:
2.9		 5ersA-3ezyA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 ILE A   6
ILE A  26
LEU A  19
HIS A  15
 None
 0.84A 5vkqB-3ezyA:
undetectable
5vkqC-3ezyA:
undetectable		 5vkqB-3ezyA:
11.51
5vkqC-3ezyA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 ILE A   6
ILE A  26
LEU A  19
HIS A  15
 None
 0.82A 5vkqC-3ezyA:
undetectable
5vkqD-3ezyA:
undetectable		 5vkqC-3ezyA:
11.51
5vkqD-3ezyA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 TYR A 279
HIS A 174
MET A 171
 None
 1.17A 6af6A-3ezyA:
undetectable		 6af6A-3ezyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 3ezy DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 ASP A 207
ASP A 152
ASN A 252
 None
 0.84A 6gngB-3ezyA:
5.3		 6gngB-3ezyA:
21.43