SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f00'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3f00 SYNAPTOTAGMIN-1
(Homo
sapiens) 		5 / 10 PHE A 210
PHE A 243
LEU A 224
PHE A 212
VAL A 183
 None
 1.38A 1q23E-3f00A:
undetectable		 1q23E-3f00A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3f00 SYNAPTOTAGMIN-1
(Homo
sapiens) 		4 / 8 THR A 201
THR A 195
VAL A 228
VAL A 181
 None
 0.79A 1t86A-3f00A:
undetectable		 1t86A-3f00A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3f00 SYNAPTOTAGMIN-1
(Homo
sapiens) 		3 / 3 ASP A 238
ASP A 178
ASP A 172
 None
 0.76A 2igtA-3f00A:
undetectable		 2igtA-3f00A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3f00 SYNAPTOTAGMIN-1
(Homo
sapiens) 		3 / 3 ASP A 238
ASP A 178
ASP A 172
 None
 0.79A 2igtB-3f00A:
undetectable		 2igtB-3f00A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 3f00 SYNAPTOTAGMIN-1
(Homo
sapiens) 		3 / 3 ARG A 199
VAL A 181
THR A 195
 SO4  A 268 (-3.8A)
None
None
 0.86A 3cyxA-3f00A:
undetectable		 3cyxA-3f00A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f00 SYNAPTOTAGMIN-1
(Homo
sapiens) 		3 / 3 THR A 201
THR A 195
LEU A 145
 None
 0.65A 5m66D-3f00A:
undetectable		 5m66D-3f00A:
16.42