SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 11 ALA A 299
LEU A 351
ILE A 316
LEU A 344
THR A 298
 None
 1.27A 1jomA-3f0hA:
undetectable		 1jomA-3f0hA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 10 ALA A 299
LEU A 351
ILE A 316
LEU A 344
THR A 298
 None
 1.29A 1tdrB-3f0hA:
2.4		 1tdrB-3f0hA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 12 ALA A 168
LEU A 189
ARG A 247
MET A 181
THR A 144
 None
None
None
None
GOL  A 360 (-2.8A)
 1.47A 1ya3A-3f0hA:
undetectable		 1ya3A-3f0hA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 12 ALA A 168
LEU A 189
ARG A 247
MET A 181
THR A 144
 None
None
None
None
GOL  A 360 (-2.8A)
 1.42A 2aa5B-3f0hA:
undetectable		 2aa5B-3f0hA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 12 LEU A 200
ALA A 201
LEU A  43
THR A 144
PHE A 158
 None
None
None
GOL  A 360 (-2.8A)
None
 1.46A 2oaxF-3f0hA:
undetectable		 2oaxF-3f0hA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 6 VAL A 283
PHE A 328
PRO A 296
THR A 297
 None
 1.38A 2q6oB-3f0hA:
undetectable		 2q6oB-3f0hA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		3 / 3 PHE A 271
ASN A 341
PHE A   4
 None
 0.82A 2zbuD-3f0hA:
undetectable		 2zbuD-3f0hA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 11 THR A 136
VAL A 131
MET A 146
ILE A 147
ALA A 165
 LLP  A 187 ( 3.0A)
None
None
None
None
 1.19A 2zbzA-3f0hA:
undetectable		 2zbzA-3f0hA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 12 ALA A 299
LEU A 351
ILE A 316
LEU A 344
THR A 298
 None
 1.23A 2zzaA-3f0hA:
undetectable		 2zzaA-3f0hA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 11 ALA A 299
LEU A 351
ILE A 316
LEU A 344
THR A 298
 None
 1.24A 2zzaB-3f0hA:
undetectable		 2zzaB-3f0hA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		3 / 3 SER A 137
GLY A  84
GLY A  88
 UNL  A 358 ( 4.9A)
None
None
 0.57A 3bogA-3f0hA:
undetectable
3bogC-3f0hA:
undetectable		 3bogA-3f0hA:
undetectable
3bogC-3f0hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		3 / 3 PHE A 171
CYH A 176
PHE A 158
 GOL  A 360 (-4.9A)
None
None
 1.03A 3cr5X-3f0hA:
undetectable		 3cr5X-3f0hA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 12 ILE A 304
ASP A 303
ALA A 301
THR A 326
ILE A 327
 None
 1.19A 3ddyA-3f0hA:
undetectable		 3ddyA-3f0hA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 11 ALA A 299
LEU A 351
ILE A 316
LEU A 344
THR A 298
 None
 1.23A 3fl9C-3f0hA:
undetectable		 3fl9C-3f0hA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 9 ALA A 299
LEU A 351
ILE A 316
LEU A 344
THR A 298
 None
 1.26A 3fl9H-3f0hA:
undetectable		 3fl9H-3f0hA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 12 ALA A 299
LEU A 351
LEU A 344
VAL A 294
THR A 298
 None
 1.17A 3ix9A-3f0hA:
undetectable		 3ix9A-3f0hA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 10 ALA A 299
LEU A 351
ILE A 316
LEU A 344
THR A 298
 None
 1.14A 3jw5B-3f0hA:
undetectable		 3jw5B-3f0hA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 7 TYR A  45
ASN A 245
LEU A 248
LYS A 252
 None
 1.10A 3lslA-3f0hA:
undetectable
3lslD-3f0hA:
undetectable		 3lslA-3f0hA:
22.28
3lslD-3f0hA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 7 TYR A  45
ASN A 245
LEU A 248
LYS A 252
 None
 1.10A 3lslA-3f0hA:
undetectable
3lslD-3f0hA:
undetectable		 3lslA-3f0hA:
22.28
3lslD-3f0hA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 6 TYR A  45
ASN A 245
LEU A 248
LYS A 252
 None
 1.09A 3lslG-3f0hA:
undetectable		 3lslG-3f0hA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 12 ALA A 168
LEU A 189
ARG A 247
MET A 181
THR A 144
 None
None
None
None
GOL  A 360 (-2.8A)
 1.44A 3vhuA-3f0hA:
undetectable		 3vhuA-3f0hA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 6 GLY A 255
LEU A 167
TYR A  45
GLU A  44
 None
 1.13A 3w9tB-3f0hA:
undetectable		 3w9tB-3f0hA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 6 LEU A 248
LYS A 252
GLU A  44
TYR A  45
 None
 1.12A 4f3tA-3f0hA:
undetectable		 4f3tA-3f0hA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 8 ASP A 143
VAL A 133
PHE A 158
LEU A 129
 GOL  A 360 (-4.6A)
None
None
None
 1.08A 4f8hA-3f0hA:
undetectable
4f8hB-3f0hA:
undetectable		 4f8hA-3f0hA:
21.59
4f8hB-3f0hA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 8 ASP A 143
VAL A 133
PHE A 158
LEU A 129
 GOL  A 360 (-4.6A)
None
None
None
 1.09A 4f8hC-3f0hA:
undetectable
4f8hD-3f0hA:
undetectable		 4f8hC-3f0hA:
21.59
4f8hD-3f0hA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 7 TYR A 121
LEU A 129
GLY A 128
PHE A 126
 GOL  A 361 (-4.1A)
None
None
None
 0.80A 4iqqA-3f0hA:
undetectable		 4iqqA-3f0hA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 7 TYR A 121
LEU A 129
GLY A 128
PHE A 126
 GOL  A 361 (-4.1A)
None
None
None
 0.86A 4iqqB-3f0hA:
undetectable		 4iqqB-3f0hA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 7 TYR A 121
LEU A 129
GLY A 128
PHE A 126
 GOL  A 361 (-4.1A)
None
None
None
 0.67A 4iqqC-3f0hA:
undetectable		 4iqqC-3f0hA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 8 TYR A 121
LEU A 129
GLY A 128
PHE A 126
 GOL  A 361 (-4.1A)
None
None
None
 0.75A 4iqqD-3f0hA:
undetectable		 4iqqD-3f0hA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 12 VAL A 208
LYS A 221
ILE A 198
VAL A 159
PHE A 157
 None
 1.20A 4y0pA-3f0hA:
undetectable		 4y0pA-3f0hA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 6 LEU A 248
LYS A 252
GLU A  44
TYR A  45
 None
 1.04A 4z4gA-3f0hA:
undetectable		 4z4gA-3f0hA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 12 GLN A 124
THR A 114
VAL A  81
ALA A 104
LEU A 105
 GOL  A 361 (-2.9A)
None
None
None
None
 1.10A 5kocA-3f0hA:
2.9		 5kocA-3f0hA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 7 TYR A 121
LEU A 129
GLY A 128
PHE A 126
 GOL  A 361 (-4.1A)
None
None
None
 0.86A 5nooA-3f0hA:
undetectable		 5nooA-3f0hA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 7 TYR A 121
LEU A 129
GLY A 128
PHE A 126
 GOL  A 361 (-4.1A)
None
None
None
 0.83A 5nooB-3f0hA:
undetectable		 5nooB-3f0hA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 6 TYR A 121
LEU A 129
GLY A 128
PHE A 126
 GOL  A 361 (-4.1A)
None
None
None
 0.84A 5nooC-3f0hA:
undetectable		 5nooC-3f0hA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 5 ALA A 178
VAL A 159
PHE A 171
ILE A 182
 None
None
GOL  A 360 (-4.9A)
None
 0.90A 5of1A-3f0hA:
undetectable		 5of1A-3f0hA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		4 / 5 ALA A 178
VAL A 159
PHE A 171
ILE A 182
 None
None
GOL  A 360 (-4.9A)
None
 0.98A 5of1B-3f0hA:
undetectable		 5of1B-3f0hA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 12 VAL A 291
VAL A   6
MET A  65
ARG A  90
GLY A 320
 None
None
LLP  A 187 ( 3.8A)
LLP  A 187 ( 4.7A)
UNL  A 358 (-3.8A)
 1.09A 6brdC-3f0hA:
undetectable		 6brdC-3f0hA:
12.08