SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 7 SER A 149
ALA A 159
SER A 181
ALA A 183
 None
 1.06A 1k5qA-3f0nA:
undetectable
1k5qB-3f0nA:
undetectable		 1k5qA-3f0nA:
19.18
1k5qB-3f0nA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 5 GLU A 239
ARG A 228
LEU A 255
ASP A 259
 None
 1.17A 1n13B-3f0nA:
undetectable
1n13C-3f0nA:
undetectable		 1n13B-3f0nA:
15.62
1n13C-3f0nA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 5 ALA A 128
ALA A 132
TYR A 131
GLN A  76
 None
 1.09A 1xl6A-3f0nA:
undetectable
1xl6B-3f0nA:
undetectable		 1xl6A-3f0nA:
22.51
1xl6B-3f0nA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 7 ARG A 161
ALA A 129
PRO A 379
ALA A  14
 None
 1.08A 2ejfA-3f0nA:
1.9		 2ejfA-3f0nA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		5 / 11 GLY A 378
SER A 162
ALA A  19
THR A 303
ILE A 197
 None
 1.13A 2nnhA-3f0nA:
undetectable		 2nnhA-3f0nA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 5 LEU A 138
LEU A 148
CYH A  12
THR A  11
 None
 1.30A 2oaxD-3f0nA:
undetectable		 2oaxD-3f0nA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		5 / 12 ALA A 128
ALA A 129
ALA A 159
VAL A 311
ILE A 197
 None
 0.82A 3h0aA-3f0nA:
undetectable		 3h0aA-3f0nA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		5 / 12 LEU A 340
LYS A 338
VAL A 326
PHE A 322
LEU A 198
 None
 1.18A 3meeA-3f0nA:
3.8		 3meeA-3f0nA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		5 / 12 LEU A 340
LYS A 338
VAL A 326
PHE A 322
LEU A 198
 None
 1.17A 3megA-3f0nA:
3.8		 3megA-3f0nA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		3 / 3 PHE A 263
CYH A 267
HIS A 264
 None
 0.80A 3u9fF-3f0nA:
undetectable		 3u9fF-3f0nA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		3 / 3 PHE A 263
CYH A 267
HIS A 264
 None
 0.88A 3u9fG-3f0nA:
undetectable		 3u9fG-3f0nA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		3 / 3 PHE A 263
CYH A 267
HIS A 264
 None
 0.86A 3u9fL-3f0nA:
undetectable		 3u9fL-3f0nA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		3 / 3 PHE A 263
CYH A 267
HIS A 264
 None
 0.95A 3u9fS-3f0nA:
undetectable		 3u9fS-3f0nA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 6 ALA A 135
ALA A  14
PRO A  15
LEU A 163
 None
 0.89A 4dtzA-3f0nA:
undetectable		 4dtzA-3f0nA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 6 ALA A 135
ALA A  14
PRO A  15
LEU A 163
 None
 0.89A 4dtzB-3f0nA:
undetectable		 4dtzB-3f0nA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 7 ALA A 135
ALA A  14
PRO A  15
LEU A 163
 None
 0.87A 4du2A-3f0nA:
undetectable		 4du2A-3f0nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 7 ALA A 135
ALA A  14
PRO A  15
LEU A 163
 None
 0.87A 4du2B-3f0nA:
undetectable		 4du2B-3f0nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		3 / 3 GLU A 150
ARG A 154
GLN A 175
 None
 0.92A 4rtbA-3f0nA:
undetectable		 4rtbA-3f0nA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 9 CYH A 160
SER A 149
LEU A  33
ILE A  32
 None
None
None
PO4  A 401 ( 4.6A)
 0.95A 4xtaA-3f0nA:
undetectable		 4xtaA-3f0nA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 8 CYH A 160
SER A 149
LEU A  33
ILE A  32
 None
None
None
PO4  A 401 ( 4.6A)
 0.98A 4xtaB-3f0nA:
undetectable		 4xtaB-3f0nA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		5 / 11 VAL A 319
PHE A 249
PHE A 252
TRP A 192
ILE A 199
 None
 1.46A 4zvmA-3f0nA:
undetectable
4zvmB-3f0nA:
undetectable		 4zvmA-3f0nA:
21.03
4zvmB-3f0nA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		3 / 3 PRO A 379
ILE A  56
SER A 162
 None
 0.81A 5fsaA-3f0nA:
0.6		 5fsaA-3f0nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 7 ILE A 197
PHE A 313
ASP A 305
SER A 260
 None
 1.42A 5nr3A-3f0nA:
undetectable		 5nr3A-3f0nA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 8 ALA A 320
ILE A 370
ALA A 372
LEU A 198
 None
 0.82A 5te8B-3f0nA:
undetectable		 5te8B-3f0nA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 7 SER A 127
SER A 156
GLY A 157
ARG A  78
 None
PO4  A 401 (-2.5A)
PO4  A 401 (-3.6A)
PO4  A 401 (-2.9A)
 1.01A 6btxA-3f0nA:
undetectable		 6btxA-3f0nA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		3 / 3 LEU A 389
GLN A 397
LYS A  49
 None
 0.90A 6exiB-3f0nA:
undetectable		 6exiB-3f0nA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		3 / 3 LEU A 389
GLN A 397
LYS A  49
 None
 0.89A 6exiA-3f0nA:
undetectable		 6exiA-3f0nA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Mus
musculus) 		4 / 5 TYR A 276
VAL A  16
MET A 215
GLY A 214
 None
None
PO4  A 401 (-4.7A)
None
 1.17A 6hd4A-3f0nA:
undetectable		 6hd4A-3f0nA:
10.54