SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UVV_B_9CRB501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3f0w	NUMB-LIKE PROTEIN (Homo sapiens)	5 / 12	LEU A 85 ALA A 176 VAL A 144 ILE A 160 CYH A 171	None	1.28A	3uvvB-3f0wA: undetectable	3uvvB-3f0wA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	3f0w	NUMB-LIKE PROTEIN (Homo sapiens)	5 / 10	GLY A 86 LEU A 175 ALA A 156 ASP A 150 SER A 158	None	1.05A	4wnuD-3f0wA: undetectable	4wnuD-3f0wA: 17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HRQ_C_IPHC101_0 (INSULIN A-CHAIN INSULIN B-CHAIN)	3f0w	NUMB-LIKE PROTEIN (Homo sapiens)	4 / 5	ILE A 170 CYH A 171 LEU A 106 HIS A 87	None	1.33A	5hrqC-3f0wA: undetectable 5hrqD-3f0wA: undetectable 5hrqL-3f0wA: undetectable	5hrqC-3f0wA: 11.21 5hrqD-3f0wA: 9.15 5hrqL-3f0wA: 9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7F_A_SAMA301_1 (PUTATIVE O-METHYLTRANSFERASE RV1220C)	3f0w	NUMB-LIKE PROTEIN (Homo sapiens)	4 / 4	SER A 158 ASP A 101 HIS A 97 ASP A 150	None None SO4 A 3 (-3.7A) None	1.47A	5x7fA-3f0wA: 0.0	5x7fA-3f0wA: 23.14

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3UVV_B_9CRB501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","3f0w","NUMB-LIKE PROTEIN","Homo sapiens",5,"LEU A  85;ALA A 176;VAL A 144;ILE A 160;CYH A 171","None","1.28A","3uvvB-3f0wA:undetectable","3uvvB-3f0wA:22.27"],["4WNU_D_QDND602_1","CYTOCHROME P450 2D6","3f0w","NUMB-LIKE PROTEIN","Homo sapiens",5,"GLY A  86;LEU A 175;ALA A 156;ASP A 150;SER A 158","None","1.05A","4wnuD-3f0wA:undetectable","4wnuD-3f0wA:17.20"],["5HRQ_C_IPHC101_0","INSULIN A-CHAIN;INSULIN B-CHAIN","3f0w","NUMB-LIKE PROTEIN","Homo sapiens",4,"ILE A 170;CYH A 171;LEU A 106;HIS A  87","None","1.33A","5hrqC-3f0wA:undetectable;5hrqD-3f0wA:undetectable;5hrqL-3f0wA:undetectable","5hrqC-3f0wA:11.21;5hrqD-3f0wA:9.15;5hrqL-3f0wA:9.15"],["5X7F_A_SAMA301_1","PUTATIVE O-METHYLTRANSFERASE RV1220C","3f0w","NUMB-LIKE PROTEIN","Homo sapiens",4,"SER A 158;ASP A 101;HIS A  97;ASP A 150","None;None;SO4 A   3 (-3.7A);None","1.47A","5x7fA-3f0wA:0.0","5x7fA-3f0wA:23.14"]]