SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK
(Escherichia
coli) 		4 / 5 THR A 197
THR A 199
GLU A  27
THR A  31
 NAP  A 300 (-4.1A)
NAP  A 300 (-2.8A)
None
None
 1.35A 1d4fB-3f1kA:
8.9		 1d4fB-3f1kA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK
(Escherichia
coli) 		5 / 11 PHE A 240
ILE A 192
ASN A  99
GLY A 195
TYR A 165
 None
None
NAP  A 300 (-3.1A)
NAP  A 300 (-4.7A)
NAP  A 300 (-4.6A)
 1.37A 1ju6A-3f1kA:
undetectable		 1ju6A-3f1kA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK
(Escherichia
coli) 		5 / 11 PHE A 240
ILE A 192
ASN A  99
GLY A 195
TYR A 165
 None
None
NAP  A 300 (-3.1A)
NAP  A 300 (-4.7A)
NAP  A 300 (-4.6A)
 1.38A 1ju6D-3f1kA:
undetectable		 1ju6D-3f1kA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK
(Escherichia
coli) 		5 / 11 LEU A  16
LEU A 139
LEU A 131
LEU A 135
MET A 175
 None
 1.29A 1mx1B-3f1kA:
4.0		 1mx1B-3f1kA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK
(Escherichia
coli) 		3 / 3 PRO A 114
ASP A 105
ASP A 119
 None
 0.66A 1sqfA-3f1kA:
8.0		 1sqfA-3f1kA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK
(Escherichia
coli) 		5 / 12 GLY A  19
ARG A  44
ASP A  70
ASN A  99
ALA A 100
 NAP  A 300 (-3.6A)
NAP  A 300 (-3.5A)
NAP  A 300 (-3.7A)
NAP  A 300 (-3.1A)
NAP  A 300 (-3.9A)
 1.01A 2bm9E-3f1kA:
5.6		 2bm9E-3f1kA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK
(Escherichia
coli) 		3 / 3 LEU A  97
LEU A 179
MET A 176
 None
 0.81A 2itzA-3f1kA:
undetectable		 2itzA-3f1kA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK
(Escherichia
coli) 		4 / 5 SER A 152
ILE A  24
TYR A 165
GLY A 195
 NAP  A 300 ( 3.7A)
NAP  A 300 (-3.5A)
NAP  A 300 (-4.6A)
NAP  A 300 (-4.7A)
 0.93A 3uboB-3f1kA:
5.8		 3uboB-3f1kA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK
(Escherichia
coli) 		3 / 3 ARG A 202
PHE A 206
PRO A 207
 NAP  A 300 (-4.8A)
None
None
 0.53A 3zoaB-3f1kA:
undetectable		 3zoaB-3f1kA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK
(Escherichia
coli) 		4 / 7 GLU A  46
THR A  18
LEU A  82
SER A  21
 None
None
None
NAP  A 300 ( 4.1A)
 1.13A 4pfjA-3f1kA:
8.5		 4pfjA-3f1kA:
19.82