SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f1r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3f1r FIBROBLAST GROWTH
FACTOR 20
(Homo
sapiens) 		5 / 12 ILE A 110
ARG A 140
SER A 153
ILE A 155
VAL A 103
 None
SO4  A 301 (-3.4A)
None
None
None
 1.18A 3adsB-3f1rA:
undetectable		 3adsB-3f1rA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3f1r FIBROBLAST GROWTH
FACTOR 20
(Homo
sapiens) 		3 / 3 SER A 152
SER A 153
HIS A 158
 None
 0.85A 3mzeA-3f1rA:
undetectable		 3mzeA-3f1rA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3f1r FIBROBLAST GROWTH
FACTOR 20
(Homo
sapiens) 		4 / 7 SER A 115
GLN A  86
PHE A  95
ASP A  82
 None
 1.43A 4kcnB-3f1rA:
undetectable		 4kcnB-3f1rA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f1r FIBROBLAST GROWTH
FACTOR 20
(Homo
sapiens) 		4 / 6 THR A 150
GLU A 144
THR A 188
HIS A 158
 None
 1.12A 4pgfA-3f1rA:
undetectable		 4pgfA-3f1rA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 3f1r FIBROBLAST GROWTH
FACTOR 20
(Homo
sapiens) 		5 / 11 LEU A 203
GLY A 112
LEU A 117
PHE A  95
LEU A  94
 None
 1.16A 4wnuA-3f1rA:
undetectable		 4wnuA-3f1rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3f1r FIBROBLAST GROWTH
FACTOR 20
(Homo
sapiens) 		5 / 12 GLY A 173
LEU A 119
ILE A 138
PHE A 190
THR A 174
 None
 1.18A 5eskA-3f1rA:
undetectable		 5eskA-3f1rA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 3f1r FIBROBLAST GROWTH
FACTOR 20
(Homo
sapiens) 		4 / 4 GLN A 142
VAL A 108
ARG A 176
ARG A 183
 None
 1.12A 6brdA-3f1rA:
undetectable		 6brdA-3f1rA:
19.91