SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 LEU A 231
LEU A 228
HIS A 303
LEU A 182
PHE A 132
 None
 1.23A 1fmlA-3f2aA:
undetectable		 1fmlA-3f2aA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 LEU A 231
LEU A 228
HIS A 303
LEU A 182
PHE A 132
 None
 1.23A 1fmlB-3f2aA:
undetectable		 1fmlB-3f2aA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.72A 1fmoE-3f2aA:
23.0		 1fmoE-3f2aA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 8 ALA A 223
TRP A 212
TYR A 218
GLY A 203
 None
 0.70A 1rukH-3f2aA:
undetectable
1rukL-3f2aA:
undetectable		 1rukH-3f2aA:
19.93
1rukL-3f2aA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 9 LEU A  44
VAL A  52
LYS A  67
LEU A 106
LEU A 118
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
None
None
 0.65A 1xkkA-3f2aA:
16.9		 1xkkA-3f2aA:
23.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		9 / 10 LEU A  44
PHE A  49
ALA A  65
ILE A 104
LEU A 120
ARG A 122
ASP A 128
LEU A 174
ILE A 185
 985  A   1 (-4.1A)
985  A   1 (-4.0A)
985  A   1 (-3.5A)
985  A   1 ( 4.7A)
985  A   1 (-4.3A)
None
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 (-3.7A)
 0.78A 1yi4A-3f2aA:
44.6		 1yi4A-3f2aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		9 / 10 LEU A  44
PHE A  49
ALA A  65
LEU A 120
ARG A 122
PRO A 123
ASP A 128
LEU A 174
ILE A 185
 985  A   1 (-4.1A)
985  A   1 (-4.0A)
985  A   1 (-3.5A)
985  A   1 (-4.3A)
None
None
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 (-3.7A)
 0.51A 1yi4A-3f2aA:
44.6		 1yi4A-3f2aA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 VAL A  52
LYS A  67
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.7A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.61A 2eufB-3f2aA:
26.7		 2eufB-3f2aA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		8 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
ASP A 167
LYS A 169
ASN A 172
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
None
985  A   1 (-4.6A)
985  A   1 ( 4.0A)
 0.84A 2fumA-3f2aA:
21.3		 2fumA-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A 169
ASN A 172
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
985  A   1 (-4.6A)
985  A   1 ( 4.0A)
 0.88A 2fumB-3f2aA:
21.2		 2fumB-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
GLY A  45
GLY A  47
VAL A  52
ALA A  65
LYS A 169
ASN A 172
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
985  A   1 (-4.6A)
 0.81A 2fumD-3f2aA:
19.5		 2fumD-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
GLY A  47
VAL A  52
ALA A  65
LYS A 169
ASN A 172
ASP A 186
 985  A   1 (-4.1A)
None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
985  A   1 (-4.6A)
985  A   1 ( 4.0A)
 0.88A 2fumD-3f2aA:
19.5		 2fumD-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		8 / 12 LEU A  44
GLY A  45
VAL A  52
LYS A  67
GLU A  89
LEU A  93
LEU A 118
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
MG  A 314 ( 4.8A)
None
985  A   1 ( 4.0A)
 0.78A 2ivuA-3f2aA:
20.1		 2ivuA-3f2aA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 8 LEU A 228
ARG A 156
VAL A 103
GLY A 102
 None
 0.89A 2po5A-3f2aA:
undetectable		 2po5A-3f2aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 8 LEU A 228
ARG A 156
VAL A 103
GLY A 102
 None
 0.87A 2po5B-3f2aA:
undetectable		 2po5B-3f2aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 6 LEU A  44
VAL A  52
LYS A  67
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.8A)
 0.57A 3cs9D-3f2aA:
16.8		 3cs9D-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		9 / 12 LEU A  44
GLY A  45
GLY A  50
VAL A  52
ALA A  65
LYS A  67
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.75A 3eygA-3f2aA:
18.5		 3eygA-3f2aA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		8 / 12 LEU A  44
GLY A  45
GLY A  50
VAL A  52
ALA A  65
LYS A  67
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.75A 3fupA-3f2aA:
17.3		 3fupA-3f2aA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 VAL A  52
ALA A  65
GLU A  89
LEU A  92
LEU A  93
ILE A 104
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
MG  A 314 (-3.6A)
None
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.64A 3gp0A-3f2aA:
17.1		 3gp0A-3f2aA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 ALA A  65
LYS A  67
GLU A  89
LEU A  92
LEU A  93
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
MG  A 314 ( 4.8A)
 0.73A 3hecA-3f2aA:
20.7		 3hecA-3f2aA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 ALA A  65
LYS A  67
GLU A  89
LEU A  93
ILE A 104
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.60A 3hecA-3f2aA:
20.7		 3hecA-3f2aA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 VAL A  52
ALA A  65
LYS A  67
LEU A  93
ILE A 104
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.71A 3hegA-3f2aA:
20.4		 3hegA-3f2aA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 8 ALA A  65
LYS A  67
GLU A  89
LEU A 118
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
 0.27A 3lfaA-3f2aA:
20.4		 3lfaA-3f2aA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A  93
ILE A 104
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.68A 3ohtA-3f2aA:
5.1		 3ohtA-3f2aA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A  93
ILE A 104
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.69A 3ohtB-3f2aA:
5.1		 3ohtB-3f2aA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 5 LEU A 139
PHE A 147
PHE A 132
ARG A 136
 None
 1.14A 3smtA-3f2aA:
undetectable		 3smtA-3f2aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
VAL A  52
ALA A  65
LYS A  67
LEU A 118
ASP A 131
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
None
None
985  A   1 (-4.8A)
 0.95A 3ug2A-3f2aA:
18.3		 3ug2A-3f2aA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 8 VAL A  52
LYS A  67
ILE A 104
ILE A 185
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 ( 4.7A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.45A 3warA-3f2aA:
25.4		 3warA-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
ALA A  65
LYS A  67
GLU A  89
HIS A 165
ARG A 166
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
None
985  A   1 (-4.8A)
 0.78A 3zosA-3f2aA:
15.5		 3zosA-3f2aA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 ALA A  65
LYS A  67
GLU A  89
ILE A 104
HIS A 165
ARG A 166
LEU A 174
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
985  A   1 ( 4.7A)
None
None
985  A   1 (-4.8A)
 0.83A 3zosB-3f2aA:
15.6		 3zosB-3f2aA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A  93
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
MG  A 314 ( 4.8A)
985  A   1 (-4.8A)
 0.54A 4agcA-3f2aA:
16.3		 4agcA-3f2aA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		9 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A 118
ASP A 131
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
None
None
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.85A 4i22A-3f2aA:
16.1		 4i22A-3f2aA:
25.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		12 / 12 PHE A  49
VAL A  52
ALA A  65
ILE A 104
ASP A 128
ASP A 131
ASP A 167
LYS A 169
ASN A 172
LEU A 174
ILE A 185
ASP A 186
 985  A   1 (-4.0A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 4.7A)
985  A   1 (-4.7A)
None
None
None
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.67A 4i41A-3f2aA:
44.5		 4i41A-3f2aA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 4 LEU A  44
LEU A 120
GLN A 127
GLU A 171
 985  A   1 (-4.1A)
985  A   1 (-4.3A)
None
None
 0.49A 4i41A-3f2aA:
44.5		 4i41A-3f2aA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		12 / 12 ILE A 133
THR A 134
LYS A 169
ASP A 170
THR A 204
VAL A 206
ASP A 234
ASP A 239
ILE A 240
GLU A 243
GLU A 247
ARG A 256
 None
 0.59A 4i41A-3f2aA:
44.5		 4i41A-3f2aA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		10 / 11 PHE A  49
ALA A  65
LYS A  67
LEU A 120
VAL A 126
ASP A 128
GLU A 171
LEU A 174
ILE A 185
ASP A 186
 985  A   1 (-4.0A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.3A)
None
985  A   1 (-4.7A)
None
985  A   1 (-4.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.56A 4iaaA-3f2aA:
44.3		 4iaaA-3f2aA:
95.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		10 / 11 PHE A  49
VAL A  52
ALA A  65
LYS A  67
LEU A 120
VAL A 126
ASP A 128
GLU A 171
LEU A 174
ILE A 185
 985  A   1 (-4.0A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.3A)
None
985  A   1 (-4.7A)
None
985  A   1 (-4.8A)
985  A   1 (-3.7A)
 0.60A 4iaaA-3f2aA:
44.3		 4iaaA-3f2aA:
95.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 GLY A  45
VAL A  52
ALA A  65
LEU A 106
LEU A 118
LEU A 174
ILE A 185
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
None
985  A   1 (-4.8A)
985  A   1 (-3.7A)
 0.66A 4ifgA-3f2aA:
22.9		 4ifgA-3f2aA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 7 VAL A  52
ALA A  65
ASP A 128
LEU A 174
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
 0.77A 4l9iA-3f2aA:
22.2		 4l9iA-3f2aA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 8 GLY A  47
VAL A  52
ALA A  65
LYS A  67
ASP A 128
 None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.7A)
 0.87A 4l9iB-3f2aA:
23.0		 4l9iB-3f2aA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 8 VAL A  52
ALA A  65
LYS A  67
ASP A 128
LEU A 174
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
 0.92A 4l9iB-3f2aA:
23.0		 4l9iB-3f2aA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
GLY A  50
VAL A  52
ALA A  65
LYS A  67
LEU A 120
ASP A 186
 985  A   1 (-4.1A)
None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.3A)
985  A   1 ( 4.0A)
 1.07A 4mkcA-3f2aA:
17.3		 4mkcA-3f2aA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		8 / 12 LEU A  44
VAL A  52
ALA A  65
LYS A  67
LEU A 120
ASP A 128
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.3A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.86A 4mkcA-3f2aA:
17.3		 4mkcA-3f2aA:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 11 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A  67
ASN A 172
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.6A)
985  A   1 ( 4.0A)
 0.90A 4o0sA-3f2aA:
23.1		 4o0sA-3f2aA:
30.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 ILE A 173
LEU A 232
TRP A 289
ILE A 284
LEU A 182
 None
 0.89A 4o1zA-3f2aA:
undetectable		 4o1zA-3f2aA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 7 ALA A  65
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.68A 4ogrE-3f2aA:
13.1		 4ogrE-3f2aA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 9 VAL A  52
ALA A  65
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.70A 4ogrI-3f2aA:
13.8		 4ogrI-3f2aA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
ALA A  65
LYS A  67
GLU A  89
LEU A 118
ASP A 131
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
None
985  A   1 (-4.8A)
 0.81A 4wkqA-3f2aA:
23.7		 4wkqA-3f2aA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 VAL A  52
ALA A  65
LYS A  67
ASP A 186
PHE A 187
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 ( 4.0A)
None
 0.68A 4xv2A-3f2aA:
18.0		 4xv2A-3f2aA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 ALA A  65
LYS A  67
LEU A  93
ASP A 186
PHE A 187
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.0A)
None
 0.78A 4xv2B-3f2aA:
18.1		 4xv2B-3f2aA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 VAL A  52
ALA A  65
LYS A  67
LEU A  93
PHE A 187
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
None
 0.71A 5cswA-3f2aA:
22.6		 5cswA-3f2aA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 VAL A  52
ALA A  65
LYS A  67
LEU A  93
PHE A 187
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
None
 0.73A 5cswB-3f2aA:
18.1		 5cswB-3f2aA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 VAL A  52
ALA A  65
ILE A 104
ASP A 131
PHE A 187
GLY A 188
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 4.7A)
None
None
None
 1.21A 5hesA-3f2aA:
7.0		 5hesA-3f2aA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 7 GLY A  45
LEU A 106
ASP A 186
PHE A 187
 985  A   1 ( 3.9A)
None
985  A   1 ( 4.0A)
None
 0.85A 5hieB-3f2aA:
22.3		 5hieB-3f2aA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 GLY A  45
VAL A  52
ALA A  65
ASP A 128
LEU A 174
ASP A 186
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.66A 5l2iA-3f2aA:
22.9		 5l2iA-3f2aA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 GLY A  45
VAL A  52
ALA A  65
ASP A 128
LEU A 174
ASP A 186
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.94A 5l2tA-3f2aA:
7.8		 5l2tA-3f2aA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 ILE A 230
VAL A 253
PRO A 279
GLU A 283
LEU A 266
 None
 1.36A 5mqtC-3f2aA:
undetectable		 5mqtC-3f2aA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 8 ALA A  65
GLU A  89
LEU A 174
ASP A 186
 985  A   1 (-3.5A)
MG  A 314 (-3.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.58A 5owrA-3f2aA:
16.2		 5owrA-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 LEU A  44
VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A 118
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
 0.68A 5vcyA-3f2aA:
24.9		 5vcyA-3f2aA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
ALA A  65
LYS A  67
GLU A  89
LEU A 118
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.78A 5y7zB-3f2aA:
26.0		 5y7zB-3f2aA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 8 LEU A  44
VAL A  52
LYS A  67
ILE A 185
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.59A 5y9mA-3f2aA:
18.5		 5y9mA-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 8 LEU A  44
VAL A  52
LYS A  67
ILE A 185
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.59A 5y9mX-3f2aA:
24.6		 5y9mX-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 7 VAL A  52
LYS A  67
ILE A 185
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.33A 5yf9B-3f2aA:
18.7		 5yf9B-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 9 LEU A  44
VAL A  52
LYS A  67
ILE A 185
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.58A 5yf9X-3f2aA:
25.0		 5yf9X-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 9 VAL A  52
LYS A  67
ILE A 104
ILE A 185
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 ( 4.7A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.39A 5yf9X-3f2aA:
25.0		 5yf9X-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A 118
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
None
 0.53A 5yu9A-3f2aA:
16.0		 5yu9A-3f2aA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 GLY A  45
VAL A  52
ALA A  65
LEU A 118
ASP A 131
LEU A 174
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
None
985  A   1 (-4.8A)
 0.85A 5yu9B-3f2aA:
16.1		 5yu9B-3f2aA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 7 VAL A  52
LYS A  67
ILE A 104
ILE A 185
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 ( 4.7A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.48A 5ywmX-3f2aA:
19.1		 5ywmX-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 5 GLY A 180
LEU A 304
SER A 146
GLN A 150
 None
 1.03A 6ji6A-3f2aA:
undetectable		 6ji6A-3f2aA:
22.12