SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.43A 1c9sA-3f2bA:
undetectable
1c9sK-3f2bA:
undetectable		 1c9sA-3f2bA:
6.36
1c9sK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 1c9sA-3f2bA:
undetectable
1c9sB-3f2bA:
undetectable		 1c9sA-3f2bA:
6.36
1c9sB-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 1c9sC-3f2bA:
undetectable
1c9sD-3f2bA:
undetectable		 1c9sC-3f2bA:
6.36
1c9sD-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 1c9sD-3f2bA:
undetectable
1c9sE-3f2bA:
undetectable		 1c9sD-3f2bA:
6.36
1c9sE-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 1c9sE-3f2bA:
undetectable
1c9sF-3f2bA:
undetectable		 1c9sE-3f2bA:
6.36
1c9sF-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 1c9sF-3f2bA:
undetectable
1c9sG-3f2bA:
undetectable		 1c9sF-3f2bA:
6.36
1c9sG-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 1c9sG-3f2bA:
undetectable
1c9sH-3f2bA:
undetectable		 1c9sG-3f2bA:
6.36
1c9sH-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 1c9sH-3f2bA:
undetectable
1c9sI-3f2bA:
undetectable		 1c9sH-3f2bA:
6.36
1c9sI-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 1c9sJ-3f2bA:
undetectable
1c9sK-3f2bA:
undetectable		 1c9sJ-3f2bA:
6.36
1c9sK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.42A 1c9sL-3f2bA:
undetectable
1c9sM-3f2bA:
undetectable		 1c9sL-3f2bA:
6.36
1c9sM-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.43A 1c9sM-3f2bA:
undetectable
1c9sN-3f2bA:
undetectable		 1c9sM-3f2bA:
6.36
1c9sN-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 1c9sO-3f2bA:
undetectable
1c9sP-3f2bA:
undetectable		 1c9sO-3f2bA:
6.36
1c9sP-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.44A 1c9sS-3f2bA:
undetectable
1c9sT-3f2bA:
undetectable		 1c9sS-3f2bA:
6.36
1c9sT-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ILE A 652
PHE A 693
VAL A 621
ALA A 406
LEU A 623
 None
 0.99A 1e7bA-3f2bA:
undetectable		 1e7bA-3f2bA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.44A 1gtfA-3f2bA:
undetectable
1gtfK-3f2bA:
undetectable		 1gtfA-3f2bA:
6.36
1gtfK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 1gtfA-3f2bA:
undetectable
1gtfB-3f2bA:
undetectable		 1gtfA-3f2bA:
6.36
1gtfB-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.41A 1gtfB-3f2bA:
undetectable
1gtfC-3f2bA:
undetectable		 1gtfB-3f2bA:
6.36
1gtfC-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.40A 1gtfE-3f2bA:
undetectable
1gtfF-3f2bA:
undetectable		 1gtfE-3f2bA:
6.36
1gtfF-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 1gtfF-3f2bA:
undetectable
1gtfG-3f2bA:
undetectable		 1gtfF-3f2bA:
6.36
1gtfG-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 1gtfG-3f2bA:
undetectable
1gtfH-3f2bA:
undetectable		 1gtfG-3f2bA:
6.36
1gtfH-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 1gtfI-3f2bA:
undetectable
1gtfJ-3f2bA:
undetectable		 1gtfI-3f2bA:
6.36
1gtfJ-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 1gtfO-3f2bA:
undetectable
1gtfP-3f2bA:
undetectable		 1gtfO-3f2bA:
6.36
1gtfP-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 1gtfP-3f2bA:
undetectable
1gtfQ-3f2bA:
undetectable		 1gtfP-3f2bA:
6.36
1gtfQ-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 1gtfT-3f2bA:
undetectable
1gtfU-3f2bA:
undetectable		 1gtfT-3f2bA:
6.36
1gtfU-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.40A 1gtfL-3f2bA:
undetectable
1gtfV-3f2bA:
undetectable		 1gtfL-3f2bA:
6.36
1gtfV-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 8 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.39A 1gtnA-3f2bA:
undetectable
1gtnB-3f2bA:
undetectable		 1gtnA-3f2bA:
6.36
1gtnB-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 THR A1067
HIS A1084
THR A1083
ILE A1055
 None
 0.76A 1gtnA-3f2bA:
undetectable
1gtnB-3f2bA:
undetectable		 1gtnA-3f2bA:
6.36
1gtnB-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.44A 1gtnR-3f2bA:
undetectable
1gtnS-3f2bA:
undetectable		 1gtnR-3f2bA:
6.36
1gtnS-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 THR A1170
LEU A1206
VAL A1209
VAL A1190
 None
 0.81A 1iwiA-3f2bA:
undetectable		 1iwiA-3f2bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 6 PRO A 816
PHE A 386
GLU A 388
VAL A 360
 None
 1.38A 1l2iB-3f2bA:
undetectable		 1l2iB-3f2bA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 PHE A 788
TYR A 705
PRO A 702
 None
 1.18A 1mcnA-3f2bA:
undetectable
1mcnB-3f2bA:
undetectable
1mcnP-3f2bA:
undetectable		 1mcnA-3f2bA:
11.71
1mcnB-3f2bA:
11.71
1mcnP-3f2bA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 THR A1170
LEU A1206
VAL A1209
VAL A1190
 None
 0.67A 1t86A-3f2bA:
undetectable		 1t86A-3f2bA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 1utdA-3f2bA:
undetectable
1utdB-3f2bA:
undetectable		 1utdA-3f2bA:
6.36
1utdB-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 8 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.43A 1utdB-3f2bA:
undetectable
1utdC-3f2bA:
undetectable		 1utdB-3f2bA:
6.36
1utdC-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 THR A1067
HIS A1084
THR A1083
ILE A1055
 None
 0.81A 1utdB-3f2bA:
undetectable
1utdC-3f2bA:
undetectable		 1utdB-3f2bA:
6.36
1utdC-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 1utdC-3f2bA:
undetectable
1utdD-3f2bA:
undetectable		 1utdC-3f2bA:
6.36
1utdD-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.42A 1utdD-3f2bA:
undetectable
1utdE-3f2bA:
undetectable		 1utdD-3f2bA:
6.36
1utdE-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 8 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 1utdF-3f2bA:
undetectable
1utdG-3f2bA:
undetectable		 1utdF-3f2bA:
6.36
1utdG-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 THR A1067
HIS A1084
THR A1083
ILE A1055
 None
 0.81A 1utdF-3f2bA:
undetectable
1utdG-3f2bA:
undetectable		 1utdF-3f2bA:
6.36
1utdG-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 1utdG-3f2bA:
undetectable
1utdH-3f2bA:
undetectable		 1utdG-3f2bA:
6.36
1utdH-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 THR A1067
HIS A1084
THR A1083
ILE A1055
 None
 0.80A 1utdI-3f2bA:
undetectable
1utdJ-3f2bA:
undetectable		 1utdI-3f2bA:
6.36
1utdJ-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 8 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.42A 1utdJ-3f2bA:
undetectable
1utdK-3f2bA:
undetectable		 1utdJ-3f2bA:
6.36
1utdK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 THR A1067
HIS A1084
THR A1083
ILE A1055
 None
 0.80A 1utdJ-3f2bA:
undetectable
1utdK-3f2bA:
undetectable		 1utdJ-3f2bA:
6.36
1utdK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.40A 1utdA-3f2bA:
undetectable
1utdK-3f2bA:
undetectable		 1utdA-3f2bA:
6.36
1utdK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 1utdN-3f2bA:
undetectable
1utdO-3f2bA:
undetectable		 1utdN-3f2bA:
6.36
1utdO-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 1utdR-3f2bA:
undetectable
1utdS-3f2bA:
undetectable		 1utdR-3f2bA:
6.36
1utdS-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 LEU A1379
PHE A1372
ARG A1429
 None
 0.89A 1xdkB-3f2bA:
undetectable		 1xdkB-3f2bA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 12 ILE A 872
LEU A 964
SER A 895
ILE A 974
THR A 823
 None
None
DGT  A1456 (-2.4A)
None
None
 1.13A 2bl9A-3f2bA:
undetectable		 2bl9A-3f2bA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 PRO A 959
SER A 935
SER A1176
ASP A1214
 None
 0.98A 2obvA-3f2bA:
undetectable		 2obvA-3f2bA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 PRO A 959
SER A 935
SER A1176
ASP A1214
 None
 0.98A 2p02A-3f2bA:
undetectable		 2p02A-3f2bA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 ASP A1092
ASN A1093
THR A1083
 None
 0.68A 2pymB-3f2bA:
undetectable		 2pymB-3f2bA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 ASP A1092
ASN A1093
THR A1083
 None
 0.67A 2q63B-3f2bA:
undetectable		 2q63B-3f2bA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 11 LEU A 347
LEU A 631
ILE A 364
MET A 398
ILE A 811
 None
 1.22A 2uxoB-3f2bA:
undetectable		 2uxoB-3f2bA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 12 ILE A1321
PHE A1406
ALA A1400
ALA A1396
LEU A1389
 None
 1.13A 2x2nD-3f2bA:
undetectable		 2x2nD-3f2bA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 7 SER A1263
CYH A1264
GLN A1180
ILE A1216
 None
 1.27A 2xz5A-3f2bA:
undetectable
2xz5B-3f2bA:
undetectable		 2xz5A-3f2bA:
11.89
2xz5B-3f2bA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 6 THR A1170
LEU A1206
VAL A1209
VAL A1190
 None
 0.84A 2z97A-3f2bA:
undetectable		 2z97A-3f2bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 7 ILE A 875
LEU A 993
PHE A 994
ARG A 825
 None
 1.07A 2zxwN-3f2bA:
2.1
2zxwW-3f2bA:
undetectable		 2zxwN-3f2bA:
20.21
2zxwW-3f2bA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 7 ILE A 875
LEU A 993
PHE A 994
ARG A 825
 None
 1.03A 3ag2N-3f2bA:
2.1
3ag2W-3f2bA:
undetectable		 3ag2N-3f2bA:
20.21
3ag2W-3f2bA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 7 ILE A 875
LEU A 993
PHE A 994
ARG A 825
 None
 0.99A 3ag4N-3f2bA:
undetectable
3ag4W-3f2bA:
undetectable		 3ag4N-3f2bA:
20.21
3ag4W-3f2bA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 12 GLN A 626
PHE A 693
ASN A 633
GLY A 630
LEU A 637
 None
None
PO4  A   3 ( 4.9A)
None
None
 1.35A 3aobC-3f2bA:
undetectable		 3aobC-3f2bA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 GLU A 961
SER A 899
VAL A 901
 None
 0.83A 3eeoA-3f2bA:
undetectable		 3eeoA-3f2bA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 6 ILE A 811
PHE A 635
PHE A 386
TYR A 402
 None
 1.28A 3elzB-3f2bA:
undetectable		 3elzB-3f2bA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 12 VAL A1398
ALA A1396
LEU A1418
LEU A1389
PHE A1383
 None
 1.22A 3hj3C-3f2bA:
undetectable		 3hj3C-3f2bA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 6 ILE A 319
VAL A 304
LEU A 324
LEU A 267
 None
 0.92A 3kp6A-3f2bA:
undetectable
3kp6B-3f2bA:
undetectable		 3kp6A-3f2bA:
10.62
3kp6B-3f2bA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 THR A 378
THR A 349
VAL A 360
ILE A 364
ILE A 375
 None
 1.42A 3kpbD-3f2bA:
undetectable		 3kpbD-3f2bA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 11 ASP A 786
ASN A 782
LEU A 785
VAL A 800
ALA A 740
 None
 1.43A 3n23C-3f2bA:
undetectable		 3n23C-3f2bA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 TYR A1298
VAL A1348
ILE A1132
GLY A1154
 None
 0.95A 3n9jA-3f2bA:
undetectable		 3n9jA-3f2bA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 ASP A 973
ASP A 975
GLY A 894
GLN A 983
 DGT  A1456 ( 2.7A)
MG  A   5 ( 2.4A)
DGT  A1456 (-3.1A)
None
 0.93A 3s3mA-3f2bA:
undetectable		 3s3mA-3f2bA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 ASP A 973
ASP A 975
GLY A 894
GLN A 983
 DGT  A1456 ( 2.7A)
MG  A   5 ( 2.4A)
DGT  A1456 (-3.1A)
None
 0.95A 3s3nA-3f2bA:
undetectable		 3s3nA-3f2bA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 7 LEU A 623
LEU A 637
PRO A 653
ILE A 652
 None
 0.86A 3s56B-3f2bA:
undetectable		 3s56B-3f2bA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 6 PHE A 963
PHE A 960
PHE A 869
ALA A 870
 None
 1.11A 3t3sB-3f2bA:
undetectable		 3t3sB-3f2bA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 7 ILE A 865
GLY A 866
SER A 863
PHE A 960
LEU A 964
 None
 1.39A 3v7pA-3f2bA:
undetectable		 3v7pA-3f2bA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 ARG A 985
ASP A1113
GLN A1112
 PO4  A   1 (-3.8A)
None
None
 0.75A 4azsA-3f2bA:
undetectable		 4azsA-3f2bA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 GLN A 353
ASP A1074
GLN A1070
 None
 0.90A 4aztA-3f2bA:
undetectable		 4aztA-3f2bA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 5 SER A 935
GLY A 955
VAL A 910
ASP A 954
 None
 1.12A 4eohA-3f2bA:
undetectable		 4eohA-3f2bA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 SER A1300
TYR A 982
ARG A 985
GLY A 887
 None
None
PO4  A   1 (-3.8A)
None
 0.90A 4fgzA-3f2bA:
undetectable
4fgzB-3f2bA:
undetectable		 4fgzA-3f2bA:
14.86
4fgzB-3f2bA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 GLN A 353
THR A1046
THR A1047
 None
 0.76A 4fu9A-3f2bA:
undetectable		 4fu9A-3f2bA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 GLN A 353
THR A1046
THR A1047
 None
 0.75A 4fufA-3f2bA:
undetectable		 4fufA-3f2bA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 PRO A 959
SER A 935
SER A1176
ASP A1214
 None
 0.88A 4kttA-3f2bA:
undetectable		 4kttA-3f2bA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 THR A1170
LEU A1206
VAL A1209
VAL A1190
 None
 0.78A 4l4bA-3f2bA:
undetectable		 4l4bA-3f2bA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 12 ILE A 753
ILE A 757
ALA A1038
THR A1041
VAL A1017
 None
 1.06A 4nkvA-3f2bA:
undetectable		 4nkvA-3f2bA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 12 ILE A 753
ILE A 757
ALA A1038
THR A1041
VAL A1017
 None
 1.06A 4nkvC-3f2bA:
undetectable		 4nkvC-3f2bA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 12 ILE A 753
ILE A 757
ALA A1038
THR A1041
VAL A1017
 None
 1.06A 4nkvD-3f2bA:
undetectable		 4nkvD-3f2bA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 12 ILE A 753
ILE A 757
ALA A1038
THR A1041
VAL A1017
 None
 1.06A 4nkxA-3f2bA:
undetectable		 4nkxA-3f2bA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 12 LEU A1178
VAL A1150
GLY A1151
SER A1134
LEU A1167
 None
 1.30A 4ot2A-3f2bA:
2.4		 4ot2A-3f2bA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 PRO A1058
MET A1061
TYR A 822
 None
 0.68A 4qa0B-3f2bA:
undetectable		 4qa0B-3f2bA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 PRO A1058
MET A1061
TYR A 822
 None
 0.66A 4qa0A-3f2bA:
undetectable		 4qa0A-3f2bA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 PRO A1058
MET A1061
TYR A 822
 None
 0.67A 4qa2B-3f2bA:
undetectable		 4qa2B-3f2bA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 11 PHE A1085
ASP A1086
ILE A1005
PRO A 387
TYR A 390
 None
 1.26A 4rtrA-3f2bA:
undetectable		 4rtrA-3f2bA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 12 PHE A1085
ASP A1086
ILE A1005
PRO A 387
TYR A 390
 None
 1.27A 4rtsA-3f2bA:
undetectable		 4rtsA-3f2bA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 LYS A 953
ARG A1285
VAL A1284
 None
 0.90A 4x3uA-3f2bA:
undetectable
4x3uB-3f2bA:
undetectable		 4x3uA-3f2bA:
5.62
4x3uB-3f2bA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y9T_A_PA1A401_1
(ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 12 GLN A 353
ASP A1074
ALA A 381
HIS A 380
GLN A 384
 None
 1.01A 4y9tA-3f2bA:
0.0		 4y9tA-3f2bA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 6 ILE A 875
LEU A 993
PHE A 994
ARG A 825
 None
 1.02A 5b1aN-3f2bA:
undetectable
5b1aW-3f2bA:
undetectable		 5b1aN-3f2bA:
20.21
5b1aW-3f2bA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 GLU A 698
HIS A 346
ASP A 671
 None
MG  A   7 (-3.4A)
None
 0.79A 5c0oG-3f2bA:
undetectable		 5c0oG-3f2bA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 4 LEU A 640
ARG A1081
ILE A 643
ILE A1069
 None
 1.35A 5dzk2-3f2bA:
undetectable
5dzkM-3f2bA:
undetectable
5dzkN-3f2bA:
undetectable		 5dzk2-3f2bA:
4.88
5dzkM-3f2bA:
11.51
5dzkN-3f2bA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5eeuA-3f2bA:
undetectable
5eeuB-3f2bA:
undetectable		 5eeuA-3f2bA:
6.36
5eeuB-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5eeuB-3f2bA:
undetectable
5eeuC-3f2bA:
undetectable		 5eeuB-3f2bA:
6.36
5eeuC-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5eeuC-3f2bA:
undetectable
5eeuD-3f2bA:
undetectable		 5eeuC-3f2bA:
6.36
5eeuD-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.41A 5eeuD-3f2bA:
undetectable
5eeuE-3f2bA:
undetectable		 5eeuD-3f2bA:
6.36
5eeuE-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5eeuE-3f2bA:
undetectable
5eeuF-3f2bA:
undetectable		 5eeuE-3f2bA:
6.36
5eeuF-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.37A 5eeuG-3f2bA:
undetectable
5eeuH-3f2bA:
undetectable		 5eeuG-3f2bA:
6.36
5eeuH-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5eeuH-3f2bA:
undetectable
5eeuI-3f2bA:
undetectable		 5eeuH-3f2bA:
6.36
5eeuI-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.44A 5eeuA-3f2bA:
undetectable
5eeuK-3f2bA:
undetectable		 5eeuA-3f2bA:
6.36
5eeuK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5eeuN-3f2bA:
undetectable
5eeuO-3f2bA:
undetectable		 5eeuN-3f2bA:
6.36
5eeuO-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5eeuP-3f2bA:
undetectable
5eeuQ-3f2bA:
undetectable		 5eeuP-3f2bA:
6.36
5eeuQ-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5eeuR-3f2bA:
undetectable
5eeuS-3f2bA:
undetectable		 5eeuR-3f2bA:
6.36
5eeuS-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5eeuS-3f2bA:
undetectable
5eeuT-3f2bA:
undetectable		 5eeuS-3f2bA:
6.36
5eeuT-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5eeuT-3f2bA:
undetectable
5eeuU-3f2bA:
undetectable		 5eeuT-3f2bA:
6.36
5eeuU-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 5eeuU-3f2bA:
undetectable
5eeuV-3f2bA:
undetectable		 5eeuU-3f2bA:
6.36
5eeuV-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5eevB-3f2bA:
undetectable
5eevC-3f2bA:
undetectable		 5eevB-3f2bA:
6.36
5eevC-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5eevC-3f2bA:
undetectable
5eevD-3f2bA:
undetectable		 5eevC-3f2bA:
6.36
5eevD-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5eevD-3f2bA:
undetectable
5eevE-3f2bA:
undetectable		 5eevD-3f2bA:
6.36
5eevE-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5eevE-3f2bA:
undetectable
5eevF-3f2bA:
undetectable		 5eevE-3f2bA:
6.36
5eevF-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.37A 5eevG-3f2bA:
undetectable
5eevH-3f2bA:
undetectable		 5eevG-3f2bA:
6.36
5eevH-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5eevH-3f2bA:
undetectable
5eevI-3f2bA:
undetectable		 5eevH-3f2bA:
6.36
5eevI-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.44A 5eevA-3f2bA:
undetectable
5eevK-3f2bA:
undetectable		 5eevA-3f2bA:
6.36
5eevK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5eevN-3f2bA:
undetectable
5eevO-3f2bA:
undetectable		 5eevN-3f2bA:
6.36
5eevO-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5eevP-3f2bA:
undetectable
5eevQ-3f2bA:
undetectable		 5eevP-3f2bA:
6.36
5eevQ-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5eevR-3f2bA:
undetectable
5eevS-3f2bA:
undetectable		 5eevR-3f2bA:
6.36
5eevS-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5eevS-3f2bA:
undetectable
5eevT-3f2bA:
undetectable		 5eevS-3f2bA:
6.36
5eevT-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5eevT-3f2bA:
undetectable
5eevU-3f2bA:
undetectable		 5eevT-3f2bA:
6.36
5eevU-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.42A 5eevU-3f2bA:
undetectable
5eevV-3f2bA:
undetectable		 5eevU-3f2bA:
6.36
5eevV-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5eewB-3f2bA:
undetectable
5eewC-3f2bA:
undetectable		 5eewB-3f2bA:
6.36
5eewC-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5eewC-3f2bA:
undetectable
5eewD-3f2bA:
undetectable		 5eewC-3f2bA:
6.36
5eewD-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5eewD-3f2bA:
undetectable
5eewE-3f2bA:
undetectable		 5eewD-3f2bA:
6.36
5eewE-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5eewE-3f2bA:
undetectable
5eewF-3f2bA:
undetectable		 5eewE-3f2bA:
6.36
5eewF-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.37A 5eewG-3f2bA:
undetectable
5eewH-3f2bA:
undetectable		 5eewG-3f2bA:
6.36
5eewH-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.44A 5eewA-3f2bA:
undetectable
5eewK-3f2bA:
undetectable		 5eewA-3f2bA:
6.36
5eewK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5eewN-3f2bA:
undetectable
5eewO-3f2bA:
undetectable		 5eewN-3f2bA:
6.36
5eewO-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5eewP-3f2bA:
undetectable
5eewQ-3f2bA:
undetectable		 5eewP-3f2bA:
6.36
5eewQ-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5eewR-3f2bA:
undetectable
5eewS-3f2bA:
undetectable		 5eewR-3f2bA:
6.36
5eewS-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5eewS-3f2bA:
undetectable
5eewT-3f2bA:
undetectable		 5eewS-3f2bA:
6.36
5eewT-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5eewT-3f2bA:
undetectable
5eewU-3f2bA:
undetectable		 5eewT-3f2bA:
6.36
5eewU-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.42A 5eewU-3f2bA:
undetectable
5eewV-3f2bA:
undetectable		 5eewU-3f2bA:
6.36
5eewV-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5eexB-3f2bA:
undetectable
5eexC-3f2bA:
undetectable		 5eexB-3f2bA:
6.36
5eexC-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5eexC-3f2bA:
undetectable
5eexD-3f2bA:
undetectable		 5eexC-3f2bA:
6.36
5eexD-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5eexD-3f2bA:
undetectable
5eexE-3f2bA:
undetectable		 5eexD-3f2bA:
6.36
5eexE-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5eexE-3f2bA:
undetectable
5eexF-3f2bA:
undetectable		 5eexE-3f2bA:
6.36
5eexF-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.36A 5eexG-3f2bA:
undetectable
5eexH-3f2bA:
undetectable		 5eexG-3f2bA:
6.36
5eexH-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.44A 5eexA-3f2bA:
undetectable
5eexK-3f2bA:
undetectable		 5eexA-3f2bA:
6.36
5eexK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5eexN-3f2bA:
undetectable
5eexO-3f2bA:
undetectable		 5eexN-3f2bA:
6.36
5eexO-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5eexP-3f2bA:
undetectable
5eexQ-3f2bA:
undetectable		 5eexP-3f2bA:
6.36
5eexQ-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5eexQ-3f2bA:
undetectable
5eexR-3f2bA:
undetectable		 5eexQ-3f2bA:
6.36
5eexR-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5eexR-3f2bA:
undetectable
5eexS-3f2bA:
undetectable		 5eexR-3f2bA:
6.36
5eexS-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5eexS-3f2bA:
undetectable
5eexT-3f2bA:
undetectable		 5eexS-3f2bA:
6.36
5eexT-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 5eexT-3f2bA:
undetectable
5eexU-3f2bA:
undetectable		 5eexT-3f2bA:
6.36
5eexU-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.42A 5eexU-3f2bA:
undetectable
5eexV-3f2bA:
undetectable		 5eexU-3f2bA:
6.36
5eexV-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5eeyB-3f2bA:
undetectable
5eeyC-3f2bA:
undetectable		 5eeyB-3f2bA:
6.36
5eeyC-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5eeyC-3f2bA:
undetectable
5eeyD-3f2bA:
undetectable		 5eeyC-3f2bA:
6.36
5eeyD-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5eeyD-3f2bA:
undetectable
5eeyE-3f2bA:
undetectable		 5eeyD-3f2bA:
6.36
5eeyE-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5eeyE-3f2bA:
undetectable
5eeyF-3f2bA:
undetectable		 5eeyE-3f2bA:
6.36
5eeyF-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.37A 5eeyG-3f2bA:
undetectable
5eeyH-3f2bA:
undetectable		 5eeyG-3f2bA:
6.36
5eeyH-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5eeyH-3f2bA:
undetectable
5eeyI-3f2bA:
undetectable		 5eeyH-3f2bA:
6.36
5eeyI-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.44A 5eeyA-3f2bA:
undetectable
5eeyK-3f2bA:
undetectable		 5eeyA-3f2bA:
6.36
5eeyK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5eeyN-3f2bA:
undetectable
5eeyO-3f2bA:
undetectable		 5eeyN-3f2bA:
6.36
5eeyO-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5eeyP-3f2bA:
undetectable
5eeyQ-3f2bA:
undetectable		 5eeyP-3f2bA:
6.36
5eeyQ-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5eeyQ-3f2bA:
undetectable
5eeyR-3f2bA:
undetectable		 5eeyQ-3f2bA:
6.36
5eeyR-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5eeyR-3f2bA:
undetectable
5eeyS-3f2bA:
undetectable		 5eeyR-3f2bA:
6.36
5eeyS-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 5eeyS-3f2bA:
undetectable
5eeyT-3f2bA:
undetectable		 5eeyS-3f2bA:
6.36
5eeyT-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5eeyT-3f2bA:
undetectable
5eeyU-3f2bA:
undetectable		 5eeyT-3f2bA:
6.36
5eeyU-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5eezB-3f2bA:
undetectable
5eezC-3f2bA:
undetectable		 5eezB-3f2bA:
6.36
5eezC-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5eezC-3f2bA:
undetectable
5eezD-3f2bA:
undetectable		 5eezC-3f2bA:
6.36
5eezD-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5eezD-3f2bA:
undetectable
5eezE-3f2bA:
undetectable		 5eezD-3f2bA:
6.36
5eezE-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5eezE-3f2bA:
undetectable
5eezF-3f2bA:
undetectable		 5eezE-3f2bA:
6.36
5eezF-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.37A 5eezG-3f2bA:
undetectable
5eezH-3f2bA:
undetectable		 5eezG-3f2bA:
6.36
5eezH-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5eezH-3f2bA:
undetectable
5eezI-3f2bA:
undetectable		 5eezH-3f2bA:
6.36
5eezI-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.41A 5eezJ-3f2bA:
undetectable
5eezK-3f2bA:
undetectable		 5eezJ-3f2bA:
6.36
5eezK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.44A 5eezA-3f2bA:
undetectable
5eezK-3f2bA:
undetectable		 5eezA-3f2bA:
6.36
5eezK-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5eezN-3f2bA:
undetectable
5eezO-3f2bA:
undetectable		 5eezN-3f2bA:
6.36
5eezO-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5eezP-3f2bA:
undetectable
5eezQ-3f2bA:
undetectable		 5eezP-3f2bA:
6.36
5eezQ-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5eezQ-3f2bA:
undetectable
5eezR-3f2bA:
undetectable		 5eezQ-3f2bA:
6.36
5eezR-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5eezR-3f2bA:
undetectable
5eezS-3f2bA:
undetectable		 5eezR-3f2bA:
6.36
5eezS-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 5eezT-3f2bA:
undetectable
5eezU-3f2bA:
undetectable		 5eezT-3f2bA:
6.36
5eezU-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.42A 5eezU-3f2bA:
undetectable
5eezV-3f2bA:
undetectable		 5eezU-3f2bA:
6.36
5eezV-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5ef0B-3f2bA:
undetectable
5ef0C-3f2bA:
undetectable		 5ef0B-3f2bA:
6.36
5ef0C-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5ef0C-3f2bA:
undetectable
5ef0D-3f2bA:
undetectable		 5ef0C-3f2bA:
6.36
5ef0D-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5ef0D-3f2bA:
undetectable
5ef0E-3f2bA:
undetectable		 5ef0D-3f2bA:
6.36
5ef0E-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5ef0E-3f2bA:
undetectable
5ef0F-3f2bA:
undetectable		 5ef0E-3f2bA:
6.36
5ef0F-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.37A 5ef0G-3f2bA:
undetectable
5ef0H-3f2bA:
undetectable		 5ef0G-3f2bA:
6.36
5ef0H-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5ef0H-3f2bA:
undetectable
5ef0I-3f2bA:
undetectable		 5ef0H-3f2bA:
6.36
5ef0I-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.41A 5ef0J-3f2bA:
undetectable
5ef0K-3f2bA:
undetectable		 5ef0J-3f2bA:
6.36
5ef0K-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.44A 5ef0A-3f2bA:
undetectable
5ef0K-3f2bA:
undetectable		 5ef0A-3f2bA:
6.36
5ef0K-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5ef0N-3f2bA:
undetectable
5ef0O-3f2bA:
undetectable		 5ef0N-3f2bA:
6.36
5ef0O-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5ef0P-3f2bA:
undetectable
5ef0Q-3f2bA:
undetectable		 5ef0P-3f2bA:
6.36
5ef0Q-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5ef0Q-3f2bA:
undetectable
5ef0R-3f2bA:
undetectable		 5ef0Q-3f2bA:
6.36
5ef0R-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5ef0R-3f2bA:
undetectable
5ef0S-3f2bA:
undetectable		 5ef0R-3f2bA:
6.36
5ef0S-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 5ef0S-3f2bA:
undetectable
5ef0T-3f2bA:
undetectable		 5ef0S-3f2bA:
6.36
5ef0T-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 5ef0T-3f2bA:
undetectable
5ef0U-3f2bA:
undetectable		 5ef0T-3f2bA:
6.36
5ef0U-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5ef1B-3f2bA:
undetectable
5ef1C-3f2bA:
undetectable		 5ef1B-3f2bA:
6.36
5ef1C-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5ef1C-3f2bA:
undetectable
5ef1D-3f2bA:
undetectable		 5ef1C-3f2bA:
6.36
5ef1D-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5ef1D-3f2bA:
undetectable
5ef1E-3f2bA:
undetectable		 5ef1D-3f2bA:
6.36
5ef1E-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5ef1E-3f2bA:
undetectable
5ef1F-3f2bA:
undetectable		 5ef1E-3f2bA:
6.36
5ef1F-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.37A 5ef1G-3f2bA:
undetectable
5ef1H-3f2bA:
undetectable		 5ef1G-3f2bA:
6.36
5ef1H-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5ef1H-3f2bA:
undetectable
5ef1I-3f2bA:
undetectable		 5ef1H-3f2bA:
6.36
5ef1I-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.41A 5ef1J-3f2bA:
undetectable
5ef1K-3f2bA:
undetectable		 5ef1J-3f2bA:
6.36
5ef1K-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.43A 5ef1A-3f2bA:
undetectable
5ef1K-3f2bA:
undetectable		 5ef1A-3f2bA:
6.36
5ef1K-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5ef1N-3f2bA:
undetectable
5ef1O-3f2bA:
undetectable		 5ef1N-3f2bA:
6.36
5ef1O-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5ef1P-3f2bA:
undetectable
5ef1Q-3f2bA:
undetectable		 5ef1P-3f2bA:
6.36
5ef1Q-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5ef1Q-3f2bA:
undetectable
5ef1R-3f2bA:
undetectable		 5ef1Q-3f2bA:
6.36
5ef1R-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5ef1R-3f2bA:
undetectable
5ef1S-3f2bA:
undetectable		 5ef1R-3f2bA:
6.36
5ef1S-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 5ef1S-3f2bA:
undetectable
5ef1T-3f2bA:
undetectable		 5ef1S-3f2bA:
6.36
5ef1T-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 5ef1T-3f2bA:
undetectable
5ef1U-3f2bA:
undetectable		 5ef1T-3f2bA:
6.36
5ef1U-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5ef2B-3f2bA:
undetectable
5ef2C-3f2bA:
undetectable		 5ef2B-3f2bA:
6.36
5ef2C-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5ef2C-3f2bA:
undetectable
5ef2D-3f2bA:
undetectable		 5ef2C-3f2bA:
6.36
5ef2D-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5ef2D-3f2bA:
undetectable
5ef2E-3f2bA:
undetectable		 5ef2D-3f2bA:
6.36
5ef2E-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5ef2E-3f2bA:
undetectable
5ef2F-3f2bA:
undetectable		 5ef2E-3f2bA:
6.36
5ef2F-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.37A 5ef2G-3f2bA:
undetectable
5ef2H-3f2bA:
undetectable		 5ef2G-3f2bA:
6.36
5ef2H-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5ef2H-3f2bA:
undetectable
5ef2I-3f2bA:
undetectable		 5ef2H-3f2bA:
6.36
5ef2I-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.41A 5ef2J-3f2bA:
undetectable
5ef2K-3f2bA:
undetectable		 5ef2J-3f2bA:
6.36
5ef2K-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.43A 5ef2A-3f2bA:
undetectable
5ef2K-3f2bA:
undetectable		 5ef2A-3f2bA:
6.36
5ef2K-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5ef2N-3f2bA:
undetectable
5ef2O-3f2bA:
undetectable		 5ef2N-3f2bA:
6.36
5ef2O-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5ef2P-3f2bA:
undetectable
5ef2Q-3f2bA:
undetectable		 5ef2P-3f2bA:
6.36
5ef2Q-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5ef2Q-3f2bA:
undetectable
5ef2R-3f2bA:
undetectable		 5ef2Q-3f2bA:
6.36
5ef2R-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5ef2R-3f2bA:
undetectable
5ef2S-3f2bA:
undetectable		 5ef2R-3f2bA:
6.36
5ef2S-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 5ef2S-3f2bA:
undetectable
5ef2T-3f2bA:
undetectable		 5ef2S-3f2bA:
6.36
5ef2T-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 5ef2T-3f2bA:
undetectable
5ef2U-3f2bA:
undetectable		 5ef2T-3f2bA:
6.36
5ef2U-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5ef3B-3f2bA:
undetectable
5ef3C-3f2bA:
undetectable		 5ef3B-3f2bA:
6.36
5ef3C-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.43A 5ef3C-3f2bA:
undetectable
5ef3D-3f2bA:
undetectable		 5ef3C-3f2bA:
6.36
5ef3D-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5ef3D-3f2bA:
undetectable
5ef3E-3f2bA:
undetectable		 5ef3D-3f2bA:
6.36
5ef3E-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.42A 5ef3E-3f2bA:
undetectable
5ef3F-3f2bA:
undetectable		 5ef3E-3f2bA:
6.36
5ef3F-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.37A 5ef3G-3f2bA:
undetectable
5ef3H-3f2bA:
undetectable		 5ef3G-3f2bA:
6.36
5ef3H-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.44A 5ef3H-3f2bA:
undetectable
5ef3I-3f2bA:
undetectable		 5ef3H-3f2bA:
6.36
5ef3I-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.41A 5ef3J-3f2bA:
undetectable
5ef3K-3f2bA:
undetectable		 5ef3J-3f2bA:
6.36
5ef3K-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.43A 5ef3A-3f2bA:
undetectable
5ef3K-3f2bA:
undetectable		 5ef3A-3f2bA:
6.36
5ef3K-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.40A 5ef3N-3f2bA:
undetectable
5ef3O-3f2bA:
undetectable		 5ef3N-3f2bA:
6.36
5ef3O-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5ef3P-3f2bA:
undetectable
5ef3Q-3f2bA:
undetectable		 5ef3P-3f2bA:
6.36
5ef3Q-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 9 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.38A 5ef3Q-3f2bA:
undetectable
5ef3R-3f2bA:
undetectable		 5ef3Q-3f2bA:
6.36
5ef3R-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.39A 5ef3R-3f2bA:
undetectable
5ef3S-3f2bA:
undetectable		 5ef3R-3f2bA:
6.36
5ef3S-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 389
THR A 349
HIS A 348
ILE A 364
SER A 385
 None
None
MG  A   7 (-3.6A)
None
None
 1.41A 5ef3T-3f2bA:
undetectable
5ef3U-3f2bA:
undetectable		 5ef3T-3f2bA:
6.36
5ef3U-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 ILE A 239
MET A 269
ASP A 273
 None
 0.85A 5h2uA-3f2bA:
undetectable		 5h2uA-3f2bA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 6 PHE A 978
SER A1300
VAL A1304
ASP A1104
 None
 1.17A 5hesA-3f2bA:
undetectable		 5hesA-3f2bA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 4 ASP A1103
HIS A1186
SER A1182
GLU A1157
 None
DGT  A1456 (-4.1A)
None
None
 1.47A 5hfjG-3f2bA:
0.0		 5hfjG-3f2bA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 7 GLY A1183
PHE A1231
CYH A1264
ASP A1215
 None
 0.75A 5hieA-3f2bA:
undetectable		 5hieA-3f2bA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 7 GLY A1183
PHE A1231
CYH A1264
ASP A1215
 None
 0.77A 5hieB-3f2bA:
undetectable		 5hieB-3f2bA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 GLY A1183
PHE A1231
CYH A1264
ASP A1215
 None
 0.77A 5hieD-3f2bA:
undetectable		 5hieD-3f2bA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 5 GLU A1197
GLU A1169
THR A1170
LEU A1184
 None
 1.03A 5hm8A-3f2bA:
undetectable		 5hm8A-3f2bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 5 GLU A1197
GLU A1169
THR A1170
LEU A1184
 None
 1.03A 5hm8B-3f2bA:
undetectable		 5hm8B-3f2bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 5 GLU A1197
GLU A1169
THR A1170
LEU A1184
 None
 1.03A 5hm8C-3f2bA:
undetectable		 5hm8C-3f2bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 5 GLU A1197
GLU A1169
THR A1170
LEU A1184
 None
 1.03A 5hm8D-3f2bA:
undetectable		 5hm8D-3f2bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 5 GLU A1197
GLU A1169
THR A1170
LEU A1184
 None
 1.03A 5hm8E-3f2bA:
undetectable		 5hm8E-3f2bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 5 GLU A1197
GLU A1169
THR A1170
LEU A1184
 None
 1.03A 5hm8F-3f2bA:
undetectable		 5hm8F-3f2bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 5 GLU A1197
GLU A1169
THR A1170
LEU A1184
 None
 1.03A 5hm8H-3f2bA:
undetectable		 5hm8H-3f2bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 ILE A 239
ARG A1029
VAL A 280
ASP A 273
 None
 1.14A 5vlmF-3f2bA:
undetectable		 5vlmF-3f2bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 LEU A 730
VAL A 687
ASP A 689
 None
 0.62A 5x23A-3f2bA:
undetectable		 5x23A-3f2bA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 5 ILE A1054
THR A 990
THR A1083
LEU A1094
 None
 1.04A 6f3mD-3f2bA:
undetectable		 6f3mD-3f2bA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 PRO A 959
SER A 935
SER A1176
ASP A1214
 None
 0.97A 6fboA-3f2bA:
undetectable		 6fboA-3f2bA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 PRO A 959
SER A 935
SER A1176
ASP A1214
 None
 0.97A 6fcbA-3f2bA:
undetectable		 6fcbA-3f2bA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 PRO A 959
SER A 935
SER A1176
ASP A1214
 None
 0.97A 6fcdA-3f2bA:
undetectable		 6fcdA-3f2bA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 THR A 361
ALA A 392
LYS A 394
 None
 0.73A 6fgcA-3f2bA:
undetectable		 6fgcA-3f2bA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		3 / 3 THR A 361
ALA A 392
LYS A 394
 None
 0.76A 6fgdA-3f2bA:
undetectable		 6fgdA-3f2bA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 6 PRO A 984
GLY A 980
TYR A 982
GLU A 981
 None
 1.03A 6gqiA-3f2bA:
undetectable		 6gqiA-3f2bA:
19.27