SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 5 GLU A 150
LEU A 128
LEU A 152
LEU A 127
 None
 1.05A 1np1A-3f2kA:
undetectable		 1np1A-3f2kA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 5 ASP A  38
ASP A 130
TYR A 157
PRO A 159
 MG  A 227 (-2.6A)
MG  A 227 (-2.5A)
None
None
 0.59A 3l2uA-3f2kA:
10.3		 3l2uA-3f2kA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 7 ASP A  38
ASP A 130
TYR A 157
PRO A 159
 MG  A 227 (-2.6A)
MG  A 227 (-2.5A)
None
None
 0.54A 3l2vA-3f2kA:
10.5		 3l2vA-3f2kA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 5 ASP A  38
ASP A 130
TYR A 157
PRO A 159
 MG  A 227 (-2.6A)
MG  A 227 (-2.5A)
None
None
 0.59A 3l2wA-3f2kA:
10.3		 3l2wA-3f2kA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 8 ASP A  38
ASP A 130
PRO A 156
TYR A 157
PRO A 159
 MG  A 227 (-2.6A)
MG  A 227 (-2.5A)
None
None
None
 0.69A 3oyaA-3f2kA:
9.5		 3oyaA-3f2kA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 8 ASP A  38
ASP A 130
TYR A 157
PRO A 159
 MG  A 227 (-2.6A)
MG  A 227 (-2.5A)
None
None
 0.67A 3s3mA-3f2kA:
10.5		 3s3mA-3f2kA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 8 ASP A  38
ASP A 130
TYR A 157
PRO A 159
 MG  A 227 (-2.6A)
MG  A 227 (-2.5A)
None
None
 0.71A 3s3nA-3f2kA:
9.5		 3s3nA-3f2kA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 7 ASP A  38
ASP A 130
TYR A 157
PRO A 159
 MG  A 227 (-2.6A)
MG  A 227 (-2.5A)
None
None
 0.64A 3s3oA-3f2kA:
9.8		 3s3oA-3f2kA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 7 LEU A 152
GLU A 150
LEU A 128
ILE A  34
 None
 0.86A 3s56B-3f2kA:
undetectable		 3s56B-3f2kA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 6 SER A  88
LEU A  90
MET A  74
THR A  76
 None
 0.75A 3thrB-3f2kA:
undetectable		 3thrB-3f2kA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 4 PRO A 153
LEU A 152
ILE A 126
ARG A  33
 None
 1.32A 4f4dA-3f2kA:
undetectable		 4f4dA-3f2kA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 6 ARG A  14
ARG A 213
ASP A 160
VAL A 218
 None
 1.42A 4xqeA-3f2kA:
undetectable		 4xqeA-3f2kA:
19.69