SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 3f3s LAMBDA-CRYSTALLIN
HOMOLOG
(Homo
sapiens) 		4 / 6 HIS A 145
ASN A 196
GLN A 199
PRO A 149
 NAD  A 601 ( 4.5A)
None
None
None
 1.26A 2ez7A-3f3sA:
undetectable		 2ez7A-3f3sA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3f3s LAMBDA-CRYSTALLIN
HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A  81
CYH A  94
SER A 122
ALA A 144
ILE A  91
 None
None
NAD  A 601 (-4.6A)
None
None
 1.31A 2xkwB-3f3sA:
undetectable		 2xkwB-3f3sA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 3f3s LAMBDA-CRYSTALLIN
HOMOLOG
(Homo
sapiens) 		5 / 9 ARG A  50
LEU A  72
VAL A  32
GLY A  18
ILE A  75
 None
 1.02A 3ekqB-3f3sA:
undetectable		 3ekqB-3f3sA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3f3s LAMBDA-CRYSTALLIN
HOMOLOG
(Homo
sapiens) 		5 / 12 ASN A 148
PRO A 149
ARG A  19
VAL A  32
ILE A  11
 NAD  A 601 (-3.8A)
None
None
None
None
 1.47A 3jb2A-3f3sA:
3.9		 3jb2A-3f3sA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 3f3s LAMBDA-CRYSTALLIN
HOMOLOG
(Homo
sapiens) 		5 / 9 ILE A 179
LEU A 175
LYS A  33
ILE A  11
GLY A   7
 None
 1.08A 3sj4X-3f3sA:
undetectable		 3sj4X-3f3sA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3f3s LAMBDA-CRYSTALLIN
HOMOLOG
(Homo
sapiens) 		4 / 7 ILE A 179
LEU A 175
LYS A  33
GLY A   7
 None
 0.95A 4hajA-3f3sA:
undetectable		 4hajA-3f3sA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 3f3s LAMBDA-CRYSTALLIN
HOMOLOG
(Homo
sapiens) 		4 / 7 ILE A 179
LEU A 175
LYS A  33
GLY A   7
 None
 0.90A 4hc3A-3f3sA:
undetectable		 4hc3A-3f3sA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 3f3s LAMBDA-CRYSTALLIN
HOMOLOG
(Homo
sapiens) 		3 / 3 VAL A 143
SER A 121
THR A 123
 None
 0.40A 4luhA-3f3sA:
undetectable		 4luhA-3f3sA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3f3s LAMBDA-CRYSTALLIN
HOMOLOG
(Homo
sapiens) 		3 / 3 SER A  20
MET A  23
ASP A  36
 None
None
NAD  A 601 (-2.7A)
 0.94A 4mm4B-3f3sA:
undetectable		 4mm4B-3f3sA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 3f3s LAMBDA-CRYSTALLIN
HOMOLOG
(Homo
sapiens) 		5 / 9 ARG A  50
LEU A  72
VAL A  32
GLY A  18
ILE A  75
 None
 1.06A 5kqxB-3f3sA:
undetectable		 5kqxB-3f3sA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 3f3s LAMBDA-CRYSTALLIN
HOMOLOG
(Homo
sapiens) 		4 / 7 VAL A  95
LEU A  74
PHE A  25
MET A  89
 NAD  A 601 (-3.9A)
None
None
None
 1.13A 6aycA-3f3sA:
undetectable		 6aycA-3f3sA:
14.05