SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 3f43 PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1081
(Thermotoga
maritima) 		5 / 12 PHE A  27
VAL A  31
VAL A  97
ILE A  99
LEU A  13
 None
 1.26A 1fm4A-3f43A:
undetectable		 1fm4A-3f43A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 3f43 PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1081
(Thermotoga
maritima) 		3 / 3 HIS A  -2
GLU A  34
HIS A  -1
 None
 0.88A 3ba0A-3f43A:
undetectable		 3ba0A-3f43A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3f43 PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1081
(Thermotoga
maritima) 		5 / 12 GLU A  18
LEU A  19
VAL A  50
ILE A  61
LEU A  45
 None
 1.05A 3fl9B-3f43A:
undetectable		 3fl9B-3f43A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3f43 PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1081
(Thermotoga
maritima) 		5 / 8 ILE A  53
ALA A  24
VAL A  60
VAL A  50
GLU A  18
 None
 1.44A 5ecnD-3f43A:
undetectable		 5ecnD-3f43A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3f43 PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1081
(Thermotoga
maritima) 		4 / 7 ILE A  43
TRP A  30
GLU A  34
VAL A  11
 None
 1.16A 6j20A-3f43A:
undetectable		 6j20A-3f43A:
13.38