SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifA-3f4bA:
3.8		 1kifA-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifB-3f4bA:
3.9		 1kifB-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifC-3f4bA:
3.8		 1kifC-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifD-3f4bA:
4.4		 1kifD-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifE-3f4bA:
3.9		 1kifE-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifF-3f4bA:
3.8		 1kifF-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifG-3f4bA:
3.9		 1kifG-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifH-3f4bA:
4.5		 1kifH-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.12A 1ve9A-3f4bA:
4.5		 1ve9A-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		3 / 3 ARG A 303
VAL A 113
TRP A 114
 None
None
NAD  A 450 (-3.8A)
 1.26A 1zviA-3f4bA:
undetectable		 1zviA-3f4bA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.11A 2du8G-3f4bA:
4.5		 2du8G-3f4bA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.12A 2du8J-3f4bA:
4.4		 2du8J-3f4bA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		5 / 12 ALA A  99
GLY A  89
GLY A  93
TRP A  96
ILE A 120
 None
NAD  A 450 (-3.5A)
NAD  A 450 (-3.3A)
None
None
 1.10A 2plwA-3f4bA:
3.4		 2plwA-3f4bA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		5 / 9 ALA A 271
ALA A 269
GLY A 263
SER A 255
ALA A 254
 None
 1.37A 2vh3A-3f4bA:
undetectable		 2vh3A-3f4bA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 8 ALA A 297
TYR A  94
ILE A 295
HIS A 199
 NAD  A 450 (-3.6A)
None
None
None
 1.03A 2zm8A-3f4bA:
undetectable		 2zm8A-3f4bA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 8 ALA A 297
TYR A  94
ILE A 295
HIS A 199
 NAD  A 450 (-3.6A)
None
None
None
 1.03A 2zmaA-3f4bA:
undetectable		 2zmaA-3f4bA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 6 THR A 374
THR A 294
LEU A 273
THR A 251
 None
 0.97A 3deuB-3f4bA:
undetectable		 3deuB-3f4bA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		6 / 12 LEU A 250
GLY A  87
VAL A 113
LEU A 125
ILE A  98
VAL A 149
 NAD  A 450 (-3.7A)
NAD  A 450 (-4.1A)
None
None
None
None
 1.49A 3frqB-3f4bA:
undetectable		 3frqB-3f4bA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 8 THR A 214
LEU A 211
SER A 267
ASN A 203
 None
None
None
NAD  A 450 (-4.0A)
 1.07A 3kp2A-3f4bA:
undetectable
3kp2B-3f4bA:
undetectable		 3kp2A-3f4bA:
18.83
3kp2B-3f4bA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 6 TYR A  94
ASN A 379
LEU A 350
ASP A 354
 None
 1.50A 3lslG-3f4bA:
undetectable		 3lslG-3f4bA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		5 / 12 ASP A 131
ILE A 135
VAL A  88
ILE A  85
ILE A 136
 None
 1.15A 3ohtA-3f4bA:
undetectable
3ohtB-3f4bA:
undetectable		 3ohtA-3f4bA:
20.86
3ohtB-3f4bA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		5 / 12 VAL A 183
ILE A 187
LEU A 197
HIS A 236
LEU A 233
 None
 1.00A 4p65B-3f4bA:
undetectable
4p65D-3f4bA:
undetectable
4p65I-3f4bA:
undetectable
4p65J-3f4bA:
undetectable		 4p65B-3f4bA:
8.15
4p65D-3f4bA:
8.15
4p65I-3f4bA:
6.29
4p65J-3f4bA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		5 / 12 VAL A 183
ILE A 187
LEU A 197
HIS A 236
LEU A 233
 None
 0.95A 4p65F-3f4bA:
undetectable
4p65H-3f4bA:
undetectable
4p65K-3f4bA:
undetectable
4p65L-3f4bA:
undetectable		 4p65F-3f4bA:
8.15
4p65H-3f4bA:
8.15
4p65K-3f4bA:
6.29
4p65L-3f4bA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 GLY A 298
TYR A 339
SER A 340
ASP A 378
 NAD  A 450 (-4.9A)
None
None
None
 1.16A 4xueA-3f4bA:
7.1		 4xueA-3f4bA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		5 / 12 GLY A 298
TYR A 339
SER A 340
ASP A 378
ALA A 297
 NAD  A 450 (-4.9A)
None
None
None
NAD  A 450 (-3.6A)
 1.18A 4ymgB-3f4bA:
7.8		 4ymgB-3f4bA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		3 / 3 ARG A 303
VAL A 113
TRP A 114
 None
None
NAD  A 450 (-3.8A)
 1.21A 5fvoA-3f4bA:
undetectable		 5fvoA-3f4bA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		3 / 3 TRP A  96
ILE A 136
SER A 103
 None
 1.01A 5gqbA-3f4bA:
2.3		 5gqbA-3f4bA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 HIS A 199
ALA A 154
SER A 229
TYR A 228
 None
NAD  A 450 (-3.5A)
None
None
 1.28A 5yodF-3f4bA:
undetectable		 5yodF-3f4bA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		5 / 12 ILE A 162
ASN A 158
SER A 232
SER A 229
TYR A 228
 None
 1.48A 6chgC-3f4bA:
undetectable		 6chgC-3f4bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		5 / 12 ILE A 162
SER A 232
SER A 229
TYR A 228
LEU A 152
 None
 1.13A 6chgC-3f4bA:
undetectable		 6chgC-3f4bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		5 / 9 VAL A 377
PHE A 361
SER A 360
LEU A 362
ILE A 295
 None
 0.87A 6fdyU-3f4bA:
undetectable		 6fdyU-3f4bA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		3 / 3 ASP A 217
ASP A 163
ASN A 173
 None
 0.85A 6gngB-3f4bA:
2.7		 6gngB-3f4bA:
20.07