SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 10 THR A  73
GLY A 100
LEU A 108
PHE A 110
GLY A 103
 None
 1.47A 1h4oA-3f4kA:
undetectable
1h4oB-3f4kA:
undetectable		 1h4oA-3f4kA:
21.12
1h4oB-3f4kA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A  19
GLY A  27
GLN A 209
GLN A 233
PHE A 229
 None
 1.05A 2azxA-3f4kA:
undetectable		 2azxA-3f4kA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A  19
GLY A  27
GLN A 209
GLN A 233
PHE A 229
 None
 1.05A 2azxB-3f4kA:
2.2		 2azxB-3f4kA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 11 TYR A  19
GLY A  27
GLN A 209
GLN A 233
PHE A 229
 None
 1.01A 2dr2A-3f4kA:
2.7		 2dr2A-3f4kA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 108
SER A 104
ASP A 106
GLU A 135
 None
 1.15A 2j2pE-3f4kA:
undetectable
2j2pF-3f4kA:
undetectable		 2j2pE-3f4kA:
21.76
2j2pF-3f4kA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A  52
GLY A  54
GLY A  56
GLY A  59
LEU A  77
 None
 0.72A 2oxtD-3f4kA:
9.0		 2oxtD-3f4kA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 157
SER A 156
VAL A 175
TRP A 153
 None
 1.32A 3jx1A-3f4kA:
undetectable
3jx1B-3f4kA:
undetectable		 3jx1A-3f4kA:
20.65
3jx1B-3f4kA:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		6 / 12 GLN A  26
GLY A  54
GLY A  56
GLN A  60
SER A 104
GLU A 121
 None
 0.78A 3kkzA-3f4kA:
36.3		 3kkzA-3f4kA:
63.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		6 / 12 ARG A  25
GLY A  27
GLY A  56
GLN A  60
PHE A  78
GLU A 121
 None
 1.44A 3kkzB-3f4kA:
36.3		 3kkzB-3f4kA:
63.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		6 / 12 GLN A  26
GLY A  27
GLY A  54
GLN A  60
GLU A 121
ASN A 126
 None
 1.15A 3kkzB-3f4kA:
36.3		 3kkzB-3f4kA:
63.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		6 / 12 GLN A  26
GLY A  27
GLY A  54
GLY A  56
GLN A  60
GLU A 121
 None
 0.42A 3kkzB-3f4kA:
36.3		 3kkzB-3f4kA:
63.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		6 / 12 GLN A  26
GLY A  54
GLY A  56
GLN A  60
SER A 104
GLU A 121
 None
 0.80A 3kkzB-3f4kA:
36.3		 3kkzB-3f4kA:
63.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 157
SER A 156
VAL A 175
TRP A 153
 None
 1.31A 3nlyA-3f4kA:
undetectable
3nlyB-3f4kA:
undetectable		 3nlyA-3f4kA:
20.65
3nlyB-3f4kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 157
SER A 156
VAL A 175
TRP A 153
 None
 1.29A 3rqlA-3f4kA:
undetectable
3rqlB-3f4kA:
undetectable		 3rqlA-3f4kA:
20.65
3rqlB-3f4kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A  75
LEU A 108
MET A 133
GLY A 132
 None
 1.03A 3selX-3f4kA:
undetectable		 3selX-3f4kA:
13.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		8 / 12 GLN A  26
GLY A  54
GLY A  56
GLN A  60
LEU A  77
SER A 104
MET A 105
GLU A 121
 None
 0.79A 3sxjA-3f4kA:
38.9		 3sxjA-3f4kA:
97.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		8 / 12 GLN A  26
GLY A  54
GLY A  56
GLN A  60
LEU A  77
SER A 104
MET A 105
GLU A 121
 None
 0.79A 3sxjB-3f4kA:
38.9		 3sxjB-3f4kA:
97.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  54
GLN A  60
MET A 105
GLU A 121
ASN A 126
 None
 1.28A 3t7sA-3f4kA:
36.3		 3t7sA-3f4kA:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		6 / 12 GLY A  54
GLY A  56
GLN A  60
ASP A  76
MET A 105
GLU A 121
 None
 0.34A 3t7sA-3f4kA:
36.3		 3t7sA-3f4kA:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		6 / 12 GLY A  54
GLY A  56
GLN A  60
ASP A  76
SER A 104
GLU A 121
 None
 0.82A 3t7sA-3f4kA:
36.3		 3t7sA-3f4kA:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		7 / 12 GLN A  26
GLY A  54
GLY A  56
GLN A  60
ASP A  76
MET A 105
GLU A 121
 None
 0.48A 3t7sB-3f4kA:
35.8		 3t7sB-3f4kA:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		7 / 12 GLN A  26
GLY A  54
GLY A  56
GLN A  60
ASP A  76
SER A 104
GLU A 121
 None
 0.77A 3t7sB-3f4kA:
35.8		 3t7sB-3f4kA:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  54
GLN A  60
MET A 105
GLU A 121
ASN A 126
 None
 1.31A 3t7sB-3f4kA:
35.8		 3t7sB-3f4kA:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  54
GLN A  60
MET A 105
GLU A 121
ASN A 126
 None
 1.32A 3t7sC-3f4kA:
36.4		 3t7sC-3f4kA:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  54
GLY A  56
GLN A  60
MET A 105
GLU A 121
 None
 0.36A 3t7sC-3f4kA:
36.4		 3t7sC-3f4kA:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  54
GLY A  56
GLN A  60
SER A 104
GLU A 121
 None
 0.82A 3t7sC-3f4kA:
36.4		 3t7sC-3f4kA:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		6 / 12 GLN A  26
GLY A  54
GLN A  60
MET A 105
GLU A 121
ASN A 126
 None
 1.33A 3t7sD-3f4kA:
33.6		 3t7sD-3f4kA:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		7 / 12 GLN A  26
GLY A  54
GLY A  56
GLN A  60
ASP A  76
MET A 105
GLU A 121
 None
 0.47A 3t7sD-3f4kA:
33.6		 3t7sD-3f4kA:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		7 / 12 GLN A  26
GLY A  54
GLY A  56
GLN A  60
ASP A  76
SER A 104
GLU A 121
 None
 0.72A 3t7sD-3f4kA:
33.6		 3t7sD-3f4kA:
57.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 157
SER A 156
VAL A 175
TRP A 153
 None
 1.34A 4d32A-3f4kA:
undetectable
4d32B-3f4kA:
undetectable		 4d32A-3f4kA:
20.65
4d32B-3f4kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 203
GLY A  27
ALA A 123
PHE A  63
THR A  57
 None
 0.75A 4hytA-3f4kA:
undetectable		 4hytA-3f4kA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 203
GLY A  27
ALA A 123
PHE A  63
THR A  57
 None
 0.74A 4hytC-3f4kA:
undetectable		 4hytC-3f4kA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A  52
GLY A  54
THR A  61
ASP A  76
MET A 105
 None
 1.34A 4pghB-3f4kA:
4.1		 4pghB-3f4kA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 157
SER A 156
VAL A 175
TRP A 153
 None
 1.33A 4v3yA-3f4kA:
undetectable
4v3yB-3f4kA:
undetectable		 4v3yA-3f4kA:
20.65
4v3yB-3f4kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		4 / 5 SER A 174
ARG A 131
GLY A 132
GLU A 135
 None
 1.07A 5cdqA-3f4kA:
undetectable
5cdqB-3f4kA:
undetectable
5cdqC-3f4kA:
undetectable		 5cdqA-3f4kA:
20.58
5cdqB-3f4kA:
21.43
5cdqC-3f4kA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		4 / 5 SER A 174
ARG A 131
GLY A 132
GLU A 135
 None
 1.07A 5cdqR-3f4kA:
undetectable
5cdqS-3f4kA:
undetectable
5cdqT-3f4kA:
undetectable		 5cdqR-3f4kA:
20.58
5cdqS-3f4kA:
21.43
5cdqT-3f4kA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 254
TYR A 252
LEU A 140
GLY A 187
PHE A 129
 None
 1.13A 5d4uA-3f4kA:
5.2		 5d4uA-3f4kA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 254
TYR A 252
LEU A 140
GLY A 187
PHE A 129
 None
 1.08A 5d4uB-3f4kA:
5.3		 5d4uB-3f4kA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 3f4k PUTATIVE
METHYLTRANSFERASE
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A  54
GLY A  56
ASP A  76
LEU A  77
MET A 105
 None
 0.92A 6i5zD-3f4kA:
11.5		 6i5zD-3f4kA:
20.61