SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 THR A  34
GLU A  37
LEU A 184
LEU A 178
GLY A 174
 None
 1.34A 1d4fA-3f4mA:
undetectable		 1d4fA-3f4mA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 116
LEU A 120
LEU A  63
VAL A 146
VAL A  45
 None
 1.20A 2po7A-3f4mA:
undetectable		 2po7A-3f4mA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 116
LEU A 120
LEU A  63
VAL A 146
VAL A  45
 None
 1.27A 2qd4A-3f4mA:
undetectable		 2qd4A-3f4mA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 LEU A 184
LEU A 178
LEU A 102
ALA A 101
 None
 0.79A 2vcvP-3f4mA:
undetectable		 2vcvP-3f4mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 SER A  52
LEU A  63
ASP A  62
LEU A  42
SER A  46
 None
 1.28A 3ko0A-3f4mA:
undetectable
3ko0B-3f4mA:
undetectable
3ko0I-3f4mA:
undetectable
3ko0J-3f4mA:
undetectable		 3ko0A-3f4mA:
23.93
3ko0B-3f4mA:
23.93
3ko0I-3f4mA:
23.93
3ko0J-3f4mA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A  63
ASP A  62
LEU A  42
SER A  46
SER A  52
 None
 1.21A 3ko0K-3f4mA:
undetectable
3ko0L-3f4mA:
undetectable
3ko0M-3f4mA:
undetectable
3ko0N-3f4mA:
undetectable		 3ko0K-3f4mA:
23.93
3ko0L-3f4mA:
23.93
3ko0M-3f4mA:
23.93
3ko0N-3f4mA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 HIS A 167
THR A  50
GLY A 154
ALA A 158
THR A 157
 None
 1.31A 4qvlV-3f4mA:
undetectable
4qvlb-3f4mA:
undetectable		 4qvlV-3f4mA:
21.28
4qvlb-3f4mA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 HIS A 167
THR A  50
GLY A 154
ALA A 158
THR A 157
 None
 1.30A 4qvlH-3f4mA:
undetectable
4qvlN-3f4mA:
undetectable		 4qvlH-3f4mA:
21.28
4qvlN-3f4mA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 HIS A 167
THR A  50
GLY A 154
ALA A 158
THR A 157
 None
 1.31A 4qvwV-3f4mA:
undetectable
4qvwb-3f4mA:
undetectable		 4qvwV-3f4mA:
21.28
4qvwb-3f4mA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 HIS A 167
THR A  50
GLY A 154
ALA A 158
THR A 157
 None
 1.31A 4qvwH-3f4mA:
undetectable
4qvwN-3f4mA:
undetectable		 4qvwH-3f4mA:
21.28
4qvwN-3f4mA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 HIS A 167
THR A  50
GLY A 154
ALA A 158
THR A 157
 None
 1.33A 4qw0V-3f4mA:
undetectable
4qw0b-3f4mA:
undetectable		 4qw0V-3f4mA:
21.28
4qw0b-3f4mA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 HIS A 167
THR A  50
GLY A 154
ALA A 158
THR A 157
 None
 1.30A 4qw1V-3f4mA:
undetectable
4qw1b-3f4mA:
undetectable		 4qw1V-3f4mA:
21.28
4qw1b-3f4mA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 HIS A 167
THR A  50
GLY A 154
ALA A 158
THR A 157
 None
 1.30A 4qw1H-3f4mA:
undetectable
4qw1N-3f4mA:
undetectable		 4qw1H-3f4mA:
21.28
4qw1N-3f4mA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 6 LEU A  42
LEU A  39
SER A  36
THR A  34
 None
 1.08A 5bojA-3f4mA:
undetectable		 5bojA-3f4mA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLY A  80
LEU A  84
ASN A  76
LEU A  73
LEU A 130
 CL  A 201 (-3.6A)
None
None
None
None
 1.47A 5fhzB-3f4mA:
undetectable		 5fhzB-3f4mA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 5 ILE A 143
LEU A  94
HIS A  74
VAL A  70
 None
 1.22A 5jmnB-3f4mA:
undetectable		 5jmnB-3f4mA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 171
LEU A 175
LEU A 156
SER A  46
VAL A  45
 None
 1.13A 5km9B-3f4mA:
undetectable		 5km9B-3f4mA:
20.50