SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 VAL A   8
GLY A   7
LEU A   6
GLY A 215
LEU A 237
 None
None
None
PXP  A 501 (-3.6A)
None
 1.01A 1fduA-3f4nA:
undetectable		 1fduA-3f4nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		4 / 7 VAL A   8
GLY A  41
THR A  67
ILE A  42
 None
 0.66A 1gtnC-3f4nA:
undetectable
1gtnD-3f4nA:
undetectable		 1gtnC-3f4nA:
13.58
1gtnD-3f4nA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		5 / 10 ALA A  37
GLY A  41
ALA A  34
THR A  67
ILE A  42
 None
 1.06A 1gtnH-3f4nA:
undetectable
1gtnI-3f4nA:
undetectable		 1gtnH-3f4nA:
13.58
1gtnI-3f4nA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 GLY A  41
ALA A  34
THR A  67
ILE A  42
ALA A  37
 None
 1.04A 1gtnM-3f4nA:
undetectable
1gtnN-3f4nA:
undetectable		 1gtnM-3f4nA:
13.58
1gtnN-3f4nA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		4 / 8 GLY A  41
ALA A  34
THR A  67
ILE A  42
 None
 0.80A 1gtnP-3f4nA:
undetectable
1gtnQ-3f4nA:
undetectable		 1gtnP-3f4nA:
13.58
1gtnQ-3f4nA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 GLY A  41
ALA A  34
THR A  67
ILE A  42
ALA A  37
 None
 0.98A 1utdL-3f4nA:
undetectable
1utdM-3f4nA:
undetectable		 1utdL-3f4nA:
13.58
1utdM-3f4nA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 ILE A 141
ALA A 143
ALA A 144
LEU A 132
ALA A 110
 None
 1.06A 1xiuB-3f4nA:
undetectable		 1xiuB-3f4nA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		5 / 11 ILE A 141
ALA A 143
ALA A 144
LEU A 132
ALA A 110
 None
 1.08A 2aclE-3f4nA:
undetectable		 2aclE-3f4nA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		4 / 6 LEU A 227
VAL A 231
ILE A 218
ILE A  13
 None
 0.88A 2piwA-3f4nA:
undetectable		 2piwA-3f4nA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		6 / 12 ALA A 136
ASP A 137
ILE A 152
GLY A 106
ALA A 191
ILE A 154
 None
 1.33A 2rkfB-3f4nA:
undetectable		 2rkfB-3f4nA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		4 / 7 ASN A   9
ALA A  31
ALA A  30
ALA A  34
 PXP  A 501 (-4.3A)
None
None
None
 0.63A 3a2qA-3f4nA:
undetectable		 3a2qA-3f4nA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 THR A 156
GLU A  72
THR A  43
GLY A 194
PHE A 133
 None
PXP  A 501 (-3.0A)
None
PXP  A 501 (-3.5A)
PXP  A 501 (-3.3A)
 1.48A 3ce6D-3f4nA:
undetectable		 3ce6D-3f4nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		4 / 6 MET A 209
VAL A 189
ILE A 175
ILE A 152
 None
 0.85A 3gcsA-3f4nA:
undetectable		 3gcsA-3f4nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		3 / 3 GLN A  66
THR A  64
LEU A 227
 None
 0.64A 3ondA-3f4nA:
undetectable		 3ondA-3f4nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		3 / 3 GLN A  66
THR A  64
LEU A 227
 None
 0.63A 3ondB-3f4nA:
2.6		 3ondB-3f4nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		4 / 8 ALA A 149
ASP A 137
ILE A 134
ILE A 154
 None
 0.87A 4kttB-3f4nA:
undetectable		 4kttB-3f4nA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		4 / 8 ALA A 149
ASP A 137
ILE A 134
ILE A 154
 None
 0.88A 4kttD-3f4nA:
undetectable		 4kttD-3f4nA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		4 / 8 ALA A 149
ASP A 137
ILE A 134
ILE A 154
 None
 0.87A 4ndnB-3f4nA:
undetectable		 4ndnB-3f4nA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		4 / 8 ALA A 149
ASP A 137
ILE A 134
ILE A 154
 None
 0.87A 4ndnD-3f4nA:
undetectable		 4ndnD-3f4nA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		4 / 6 ARG A 139
ASP A 108
VAL A 120
ALA A 119
 None
 1.01A 4nkxA-3f4nA:
undetectable		 4nkxA-3f4nA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		5 / 12 ASP A  77
GLU A  78
LEU A  46
ARG A  50
LEU A 123
 None
 1.29A 4xi3A-3f4nA:
undetectable		 4xi3A-3f4nA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Yersinia
pestis) 		5 / 10 LEU A  61
ASP A  40
ILE A 219
VAL A  44
ILE A  42
 None
 1.06A 5kr1A-3f4nA:
undetectable		 5kr1A-3f4nA:
18.18