SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE
(Salmonella
enterica) 		4 / 7 LEU A  73
ALA A  78
VAL A  56
VAL A  31
 None
 0.90A 1epbA-3f4wA:
undetectable		 1epbA-3f4wA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE
(Salmonella
enterica) 		5 / 12 THR A 137
GLY A 187
SER A 188
GLY A 167
ILE A  28
 MLI  A 300 ( 4.6A)
MLI  A 300 (-3.3A)
None
MLI  A 300 (-3.5A)
None
 1.01A 2b25B-3f4wA:
undetectable		 2b25B-3f4wA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE
(Salmonella
enterica) 		5 / 12 LEU A   3
ILE A 185
GLY A 187
ALA A   6
LEU A   7
 None
None
MLI  A 300 (-3.3A)
MLI  A 300 ( 4.2A)
None
 1.24A 3n8xA-3f4wA:
undetectable		 3n8xA-3f4wA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE
(Salmonella
enterica) 		5 / 12 LEU A  72
GLY A  77
ALA A  78
ASP A  79
LEU A  73
 None
 0.83A 3ogqB-3f4wA:
undetectable		 3ogqB-3f4wA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE
(Salmonella
enterica) 		5 / 12 LEU A 122
GLY A 127
ALA A 128
ASP A 129
LEU A 123
 None
 0.99A 3ogqB-3f4wA:
undetectable		 3ogqB-3f4wA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE
(Salmonella
enterica) 		4 / 8 ILE A 147
ALA A 165
TYR A 176
HIS A 134
 None
MLI  A 300 ( 4.2A)
None
MLI  A 300 (-4.1A)
 0.81A 5ecnD-3f4wA:
undetectable		 5ecnD-3f4wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE
(Salmonella
enterica) 		3 / 3 LYS A   1
ASP A  27
ARG A 161
 None
 0.88A 5jwaA-3f4wA:
undetectable
5jwaH-3f4wA:
undetectable		 5jwaA-3f4wA:
17.72
5jwaH-3f4wA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE
(Salmonella
enterica) 		5 / 12 MET A 110
ALA A  99
SER A  70
ILE A  96
CYH A  95
 None
 1.39A 5mlmA-3f4wA:
2.7		 5mlmA-3f4wA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE
(Salmonella
enterica) 		5 / 12 VAL A  31
GLN A   4
ILE A 203
ALA A 200
VAL A 186
 None
None
None
None
MLI  A 300 ( 4.6A)
 1.14A 5n0sB-3f4wA:
undetectable		 5n0sB-3f4wA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE
(Salmonella
enterica) 		4 / 6 ASP A 138
GLU A   9
ASP A   8
GLU A  30
 None
 1.19A 6mn5C-3f4wA:
undetectable		 6mn5C-3f4wA:
18.45