SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 3f59 ANKYRIN-1
(Homo
sapiens) 		5 / 9 ALA A 977
TYR A1062
LEU A 978
GLY A 979
GLY A 982
 None
 1.21A 1ncwH-3f59A:
undetectable
1ncwL-3f59A:
undetectable		 1ncwH-3f59A:
21.00
1ncwL-3f59A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3f59 ANKYRIN-1
(Homo
sapiens) 		5 / 8 ALA A 977
TYR A1062
LEU A 978
GLY A 979
GLY A 982
 None
 1.20A 1rukH-3f59A:
undetectable
1rukL-3f59A:
undetectable		 1rukH-3f59A:
21.00
1rukL-3f59A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3f59 ANKYRIN-1
(Homo
sapiens) 		5 / 9 ALA A 977
TYR A1062
LEU A 978
GLY A 979
GLY A 982
 None
 1.19A 1rumH-3f59A:
undetectable
1rumL-3f59A:
undetectable		 1rumH-3f59A:
21.00
1rumL-3f59A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3f59 ANKYRIN-1
(Homo
sapiens) 		4 / 5 GLU A1038
PRO A 939
ILE A 938
GLY A 924
 None
 0.88A 2qeuA-3f59A:
undetectable
2qeuC-3f59A:
undetectable		 2qeuA-3f59A:
22.73
2qeuC-3f59A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3f59 ANKYRIN-1
(Homo
sapiens) 		4 / 8 ILE A 949
CYH A 951
ARG A 952
LEU A1061
 None
 0.71A 4xtaB-3f59A:
undetectable		 4xtaB-3f59A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3f59 ANKYRIN-1
(Homo
sapiens) 		5 / 12 ILE A 976
GLY A 979
ILE A 949
ILE A1055
LEU A1040
 None
None
None
BR  A   3 (-4.9A)
None
 1.02A 5e72A-3f59A:
undetectable		 5e72A-3f59A:
17.60