SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE
(Legionella
pneumophila) 		4 / 5 ILE A  34
SER A  44
LEU A  38
ASN A  35
 None
 1.18A 1y0xX-3f5bA:
undetectable		 1y0xX-3f5bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE
(Legionella
pneumophila) 		4 / 5 ASP A  95
GLY A  42
ALA A  61
ILE A  77
 CHX  A 182 (-4.0A)
None
None
None
 0.84A 2aofA-3f5bA:
undetectable		 2aofA-3f5bA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE
(Legionella
pneumophila) 		4 / 5 ASP A  95
GLY A  42
ALA A  61
ILE A  77
 CHX  A 182 (-4.0A)
None
None
None
 0.84A 2aohB-3f5bA:
undetectable		 2aohB-3f5bA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE
(Legionella
pneumophila) 		4 / 5 GLN A 111
PHE A  12
PHE A  73
GLY A 105
 None
 1.22A 2qmzA-3f5bA:
undetectable
2qmzB-3f5bA:
undetectable		 2qmzA-3f5bA:
21.94
2qmzB-3f5bA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE
(Legionella
pneumophila) 		4 / 4 ASP A  89
GLY A  90
LYS A  83
GLU A  82
 None
 1.28A 3hznD-3f5bA:
undetectable		 3hznD-3f5bA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE
(Legionella
pneumophila) 		4 / 8 TYR A  75
LEU A  26
LEU A  38
LEU A  43
 None
 1.01A 4l1xA-3f5bA:
undetectable		 4l1xA-3f5bA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE
(Legionella
pneumophila) 		3 / 3 GLY A 107
GLN A 111
LYS A 144
 FMT  A 186 ( 3.7A)
None
None
 0.96A 5imsB-3f5bA:
undetectable		 5imsB-3f5bA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE
(Legionella
pneumophila) 		5 / 10 VAL A  25
LEU A  43
ASN A  35
ILE A  47
THR A  46
 None
 1.22A 6d9hR-3f5bA:
undetectable		 6d9hR-3f5bA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE
(Legionella
pneumophila) 		4 / 7 HIS A 162
TYR A 142
TRP A 157
HIS A 158
 None
EDO  A 187 ( 4.8A)
None
None
 1.48A 6nmfN-3f5bA:
undetectable
6nmfP-3f5bA:
undetectable		 6nmfN-3f5bA:
14.59
6nmfP-3f5bA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE
(Legionella
pneumophila) 		4 / 7 HIS A 162
TYR A 142
TRP A 157
HIS A 158
 None
EDO  A 187 ( 4.8A)
None
None
 1.49A 6nmpN-3f5bA:
undetectable
6nmpP-3f5bA:
undetectable		 6nmpN-3f5bA:
14.59
6nmpP-3f5bA:
19.84