SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P93_D_DEXD4999_2 (GLUCOCORTICOID RECEPTOR)	3f5c	NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1 (Mus musculus)	4 / 5	LEU B 288 MET B 464 LEU B 468 GLN B 284	None	1.12A	1p93D-3f5cB: 12.7	1p93D-3f5cB: 22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q63_A_1UNA1001_4 (PROTEASE RETROPEPSIN)	3f5c	NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1 (Mus musculus)	3 / 3	ASP B 392 ASN B 390 THR B 409	None	0.78A	2q63B-3f5cB: undetectable	2q63B-3f5cB: 18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D90_A_NOGA1001_1 (PROGESTERONE RECEPTOR)	3f5c	NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1 (Mus musculus)	5 / 12	LEU B 265 LEU B 268 LEU B 468 MET B 460 LEU B 297	None	1.47A	3d90A-3f5cB: 12.8	3d90A-3f5cB: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5F_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6)	3f5c	NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1 (Mus musculus)	4 / 8	THR B 267 MET B 298 ALA B 294 SER B 443	None	1.07A	5l5fY-3f5cB: undetectable 5l5fZ-3f5cB: undetectable	5l5fY-3f5cB: 20.71 5l5fZ-3f5cB: 20.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1P93_D_DEXD4999_2","GLUCOCORTICOID RECEPTOR","3f5c","NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1","Mus musculus",4,"LEU B 288;MET B 464;LEU B 468;GLN B 284","None","1.12A","1p93D-3f5cB:12.7","1p93D-3f5cB:22.07"],["2Q63_A_1UNA1001_4","PROTEASE RETROPEPSIN;PROTEASE RETROPEPSIN","3f5c","NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1","Mus musculus",3,"ASP B 392;ASN B 390;THR B 409","None","0.78A","2q63B-3f5cB:undetectable","2q63B-3f5cB:18.86"],["3D90_A_NOGA1001_1","PROGESTERONE RECEPTOR","3f5c","NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1","Mus musculus",5,"LEU B 265;LEU B 268;LEU B 468;MET B 460;LEU B 297","None","1.47A","3d90A-3f5cB:12.8","3d90A-3f5cB:22.92"],["5L5F_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6","3f5c","NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1","Mus musculus",4,"THR B 267;MET B 298;ALA B 294;SER B 443","None","1.07A","5l5fY-3f5cB:undetectable;5l5fZ-3f5cB:undetectable","5l5fY-3f5cB:20.71;5l5fZ-3f5cB:20.59"]]