SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		4 / 4 GLY A  71
ASP A  73
GLY A  47
THR A  51
 None
 1.00A 1hxbB-3f5dA:
undetectable		 1hxbB-3f5dA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		4 / 8 VAL A 143
GLY A 153
THR A 154
ALA A 155
 None
 0.86A 2a1hA-3f5dA:
undetectable
2a1hB-3f5dA:
undetectable		 2a1hA-3f5dA:
19.30
2a1hB-3f5dA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		5 / 11 GLY A 153
GLU A  18
ILE A  70
TRP A  75
ALA A  15
 None
 1.13A 2a58A-3f5dA:
4.1
2a58E-3f5dA:
3.4		 2a58A-3f5dA:
22.49
2a58E-3f5dA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		5 / 12 ILE A  70
TRP A  75
ALA A  15
GLY A 153
GLU A  18
 None
 1.15A 2a58A-3f5dA:
4.0
2a58B-3f5dA:
4.1		 2a58A-3f5dA:
22.49
2a58B-3f5dA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		5 / 12 ILE A  70
TRP A  75
ALA A  15
GLY A 153
GLU A  18
 None
 1.13A 2a58B-3f5dA:
4.1
2a58C-3f5dA:
3.9		 2a58B-3f5dA:
22.49
2a58C-3f5dA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		5 / 11 ILE A  70
TRP A  75
ALA A  15
GLY A 153
GLU A  18
 None
 1.13A 2a58C-3f5dA:
3.9
2a58D-3f5dA:
3.9		 2a58C-3f5dA:
22.49
2a58D-3f5dA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		5 / 12 ILE A  70
TRP A  75
ALA A  15
GLY A 153
GLU A  18
 None
 1.15A 2a58D-3f5dA:
4.1
2a58E-3f5dA:
4.0		 2a58D-3f5dA:
22.49
2a58E-3f5dA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		4 / 4 GLY A  71
ASP A  73
GLY A  47
THR A  51
 None
 1.00A 3k4vC-3f5dA:
undetectable		 3k4vC-3f5dA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		5 / 10 VAL A 103
GLY A 101
VAL A 143
ASN A 120
GLY A 119
 None
 1.22A 3km6A-3f5dA:
undetectable		 3km6A-3f5dA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		5 / 9 VAL A 103
GLY A 101
VAL A 143
ASN A 120
GLY A 119
 None
 1.26A 3kmoA-3f5dA:
undetectable		 3kmoA-3f5dA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		5 / 12 LEU A   9
ILE A  70
GLY A 101
ALA A 102
LEU A 106
 None
 1.26A 3n8xA-3f5dA:
undetectable		 3n8xA-3f5dA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		5 / 12 LEU A  11
ILE A  70
GLY A 101
ALA A 102
LEU A 106
 None
 1.24A 3n8xA-3f5dA:
undetectable		 3n8xA-3f5dA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		4 / 4 ILE A  42
SER A  52
ASP A  12
ASP A  73
 None
 1.37A 4krhB-3f5dA:
3.1		 4krhB-3f5dA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		4 / 4 LYS A 126
ASN A 109
ASP A  78
ASP A 127
 None
 1.45A 4o1eB-3f5dA:
0.2		 4o1eB-3f5dA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		4 / 7 ALA A  97
PRO A  95
MET A 166
LEU A  67
 None
 0.87A 5dzkD-3f5dA:
undetectable
5dzkR-3f5dA:
undetectable		 5dzkD-3f5dA:
20.59
5dzkR-3f5dA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		3 / 3 GLY A  48
GLY A  47
GLN A  13
 None
 0.38A 5imsA-3f5dA:
2.3		 5imsA-3f5dA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 3f5d PROTEIN YDEA
(Bacillus
subtilis) 		5 / 10 GLU A  18
GLY A  71
GLY A  72
ILE A  99
GLY A 153
 None
 0.41A 6e5zA-3f5dA:
8.7		 6e5zA-3f5dA:
23.58