SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3f5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SN5_C_T3C601_2 (TRANSTHYRETIN)	3f5o	THIOESTERASE SUPERFAMILY MEMBER 2 (Homo sapiens)	4 / 8	LYS A 136 THR A 116 ALA A 114 VAL A 106	UOC A 149 (-3.1A) None None None	0.89A	1sn5C-3f5oA: undetectable	1sn5C-3f5oA: 24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TYR_B_9CRB130_1 (TRANSTHYRETIN)	3f5o	THIOESTERASE SUPERFAMILY MEMBER 2 (Homo sapiens)	4 / 7	LYS A 136 THR A 116 ALA A 114 VAL A 106	UOC A 149 (-3.1A) None None None	0.83A	1tyrB-3f5oA: undetectable	1tyrB-3f5oA: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZU_A_MTLA870_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	3f5o	THIOESTERASE SUPERFAMILY MEMBER 2 (Homo sapiens)	4 / 8	SER A 117 ARG A 133 ASN A 87 ASP A 119	None	1.11A	1zzuA-3f5oA: undetectable	1zzuA-3f5oA: 16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IIZ_B_LURB201_1 (TRANSTHYRETIN)	3f5o	THIOESTERASE SUPERFAMILY MEMBER 2 (Homo sapiens)	4 / 8	LYS A 136 THR A 116 ALA A 114 VAL A 106	UOC A 149 (-3.1A) None None None	0.82A	4iizB-3f5oA: undetectable	4iizB-3f5oA: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IK7_A_IMNA201_1 (TRANSTHYRETIN)	3f5o	THIOESTERASE SUPERFAMILY MEMBER 2 (Homo sapiens)	4 / 7	LYS A 136 THR A 116 ALA A 114 VAL A 106	UOC A 149 (-3.1A) None None None	0.80A	4ik7A-3f5oA: undetectable	4ik7A-3f5oA: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IK7_B_IMNB201_1 (TRANSTHYRETIN)	3f5o	THIOESTERASE SUPERFAMILY MEMBER 2 (Homo sapiens)	4 / 8	LYS A 136 THR A 116 ALA A 114 VAL A 106	UOC A 149 (-3.1A) None None None	0.86A	4ik7B-3f5oA: undetectable	4ik7B-3f5oA: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J7X_B_SASB804_1 (SEPIAPTERIN REDUCTASE)	3f5o	THIOESTERASE SUPERFAMILY MEMBER 2 (Homo sapiens)	5 / 12	LEU A 73 GLN A 109 ALA A 114 GLY A 139 LEU A 138	None None None COA A 150 (-3.3A) None	1.18A	4j7xB-3f5oA: undetectable	4j7xB-3f5oA: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AXA_A_ADNA502_2 (ADENOSYLHOMOCYSTEINA SE)	3f5o	THIOESTERASE SUPERFAMILY MEMBER 2 (Homo sapiens)	4 / 5	GLU A 41 THR A 29 HIS A 56 LEU A 55	None None CL A 151 (-3.6A) None	1.28A	5axaA-3f5oA: undetectable	5axaA-3f5oA: 17.13

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1SN5_C_T3C601_2","TRANSTHYRETIN","3f5o","THIOESTERASE SUPERFAMILY MEMBER 2","Homo sapiens",4,"LYS A 136;THR A 116;ALA A 114;VAL A 106","UOC A 149 (-3.1A);None;None;None","0.89A","1sn5C-3f5oA:undetectable","1sn5C-3f5oA:24.85"],["1TYR_B_9CRB130_1","TRANSTHYRETIN","3f5o","THIOESTERASE SUPERFAMILY MEMBER 2","Homo sapiens",4,"LYS A 136;THR A 116;ALA A 114;VAL A 106","UOC A 149 (-3.1A);None;None;None","0.83A","1tyrB-3f5oA:undetectable","1tyrB-3f5oA:21.25"],["1ZZU_A_MTLA870_0","NITRIC-OXIDE SYNTHASE, BRAIN","3f5o","THIOESTERASE SUPERFAMILY MEMBER 2","Homo sapiens",4,"SER A 117;ARG A 133;ASN A  87;ASP A 119","None","1.11A","1zzuA-3f5oA:undetectable","1zzuA-3f5oA:16.45"],["4IIZ_B_LURB201_1","TRANSTHYRETIN","3f5o","THIOESTERASE SUPERFAMILY MEMBER 2","Homo sapiens",4,"LYS A 136;THR A 116;ALA A 114;VAL A 106","UOC A 149 (-3.1A);None;None;None","0.82A","4iizB-3f5oA:undetectable","4iizB-3f5oA:21.25"],["4IK7_A_IMNA201_1","TRANSTHYRETIN","3f5o","THIOESTERASE SUPERFAMILY MEMBER 2","Homo sapiens",4,"LYS A 136;THR A 116;ALA A 114;VAL A 106","UOC A 149 (-3.1A);None;None;None","0.80A","4ik7A-3f5oA:undetectable","4ik7A-3f5oA:21.25"],["4IK7_B_IMNB201_1","TRANSTHYRETIN","3f5o","THIOESTERASE SUPERFAMILY MEMBER 2","Homo sapiens",4,"LYS A 136;THR A 116;ALA A 114;VAL A 106","UOC A 149 (-3.1A);None;None;None","0.86A","4ik7B-3f5oA:undetectable","4ik7B-3f5oA:21.25"],["4J7X_B_SASB804_1","SEPIAPTERIN REDUCTASE","3f5o","THIOESTERASE SUPERFAMILY MEMBER 2","Homo sapiens",5,"LEU A  73;GLN A 109;ALA A 114;GLY A 139;LEU A 138","None;None;None;COA A 150 (-3.3A);None","1.18A","4j7xB-3f5oA:undetectable","4j7xB-3f5oA:21.33"],["5AXA_A_ADNA502_2","ADENOSYLHOMOCYSTEINASE","3f5o","THIOESTERASE SUPERFAMILY MEMBER 2","Homo sapiens",4,"GLU A  41;THR A  29;HIS A  56;LEU A  55","None;None; CL A 151 (-3.6A);None","1.28A","5axaA-3f5oA:undetectable","5axaA-3f5oA:17.13"]]